The Role of Oxidative Stress in the Clinical Manifestations of Childhood Asthma
Samo za registrovane korisnike
2017
Autori
Topić, AleksandraFrancuski, Djordje
Nikolić, Aleksandra
Milosević, Katarina
Jovicić, Snežana
Marković, Bojan
Đukić, Mirjana
Radojković, Dragica
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Introduction: The significance of oxidative stress in pathogenesis of childhood asthma was recognized, but its role in the clinical manifestations of disease is still unclear. Materials and Methods: The study was conducted in 96 asthmatic children. The urinary biomarker of oxidative stress, 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG/creatinine) was determined by using HPLC-MS/MS. ELISA was performed to measure myeloperoxidase (MPO) and Cu,Zn-superoxide dismutase (Cu, Zn-SOD) in serum. Results: Logistic regression analysis revealed that female gender, tobacco smoke exposure, and increased 8-oxodG/creatinine were associated with risk for intermittent asthma, while the positive allergy test and increased Cu, Zn-SOD were associated with eczema in asthmatic children. Higher MPO (p = 0.033), and percent of granulocytes (p = 0.030) were found in severe persistent asthma in comparison to intermittent or mild persistent asthma. Conclusion: The main findings that TSE-induced oxidative stress is... a risk for intermittent asthma and eczema may be clinically significant for the disease prevention and therapeutic improvements.
Ključne reči:
superoxide dismutase / myeloperoxidase / eczema / childhood asthma / 8-oxodGIzvor:
Fetal and Pediatric Pathology, 2017, 36, 4, 294-303Izdavač:
- Taylor & Francis Inc, Philadelphia
Finansiranje / projekti:
- Kompleksne bolesti kao model sistem za proučavanje modulacije fenotipa-strukturna i funkcionalna analiza molekularnih biomarkera (RS-MESTD-Basic Research (BR or ON)-173008)
- Preventivni, terapijski i etički pristup prekliničkim i kliničkim istraživanjima gena i modulatora redoks ćelijske signalizacije u imunskom, inflamatornom i proliferativnom odgovoru ćelije (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41018)
DOI: 10.1080/15513815.2017.1315199
ISSN: 1551-3815
PubMed: 28481134
WoS: 000416502700004
Scopus: 2-s2.0-85019046891
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Topić, Aleksandra AU - Francuski, Djordje AU - Nikolić, Aleksandra AU - Milosević, Katarina AU - Jovicić, Snežana AU - Marković, Bojan AU - Đukić, Mirjana AU - Radojković, Dragica PY - 2017 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1061 AB - Introduction: The significance of oxidative stress in pathogenesis of childhood asthma was recognized, but its role in the clinical manifestations of disease is still unclear. Materials and Methods: The study was conducted in 96 asthmatic children. The urinary biomarker of oxidative stress, 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG/creatinine) was determined by using HPLC-MS/MS. ELISA was performed to measure myeloperoxidase (MPO) and Cu,Zn-superoxide dismutase (Cu, Zn-SOD) in serum. Results: Logistic regression analysis revealed that female gender, tobacco smoke exposure, and increased 8-oxodG/creatinine were associated with risk for intermittent asthma, while the positive allergy test and increased Cu, Zn-SOD were associated with eczema in asthmatic children. Higher MPO (p = 0.033), and percent of granulocytes (p = 0.030) were found in severe persistent asthma in comparison to intermittent or mild persistent asthma. Conclusion: The main findings that TSE-induced oxidative stress is a risk for intermittent asthma and eczema may be clinically significant for the disease prevention and therapeutic improvements. PB - Taylor & Francis Inc, Philadelphia T2 - Fetal and Pediatric Pathology T1 - The Role of Oxidative Stress in the Clinical Manifestations of Childhood Asthma EP - 303 IS - 4 SP - 294 VL - 36 DO - 10.1080/15513815.2017.1315199 ER -
@article{ author = "Topić, Aleksandra and Francuski, Djordje and Nikolić, Aleksandra and Milosević, Katarina and Jovicić, Snežana and Marković, Bojan and Đukić, Mirjana and Radojković, Dragica", year = "2017", abstract = "Introduction: The significance of oxidative stress in pathogenesis of childhood asthma was recognized, but its role in the clinical manifestations of disease is still unclear. Materials and Methods: The study was conducted in 96 asthmatic children. The urinary biomarker of oxidative stress, 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG/creatinine) was determined by using HPLC-MS/MS. ELISA was performed to measure myeloperoxidase (MPO) and Cu,Zn-superoxide dismutase (Cu, Zn-SOD) in serum. Results: Logistic regression analysis revealed that female gender, tobacco smoke exposure, and increased 8-oxodG/creatinine were associated with risk for intermittent asthma, while the positive allergy test and increased Cu, Zn-SOD were associated with eczema in asthmatic children. Higher MPO (p = 0.033), and percent of granulocytes (p = 0.030) were found in severe persistent asthma in comparison to intermittent or mild persistent asthma. Conclusion: The main findings that TSE-induced oxidative stress is a risk for intermittent asthma and eczema may be clinically significant for the disease prevention and therapeutic improvements.", publisher = "Taylor & Francis Inc, Philadelphia", journal = "Fetal and Pediatric Pathology", title = "The Role of Oxidative Stress in the Clinical Manifestations of Childhood Asthma", pages = "303-294", number = "4", volume = "36", doi = "10.1080/15513815.2017.1315199" }
Topić, A., Francuski, D., Nikolić, A., Milosević, K., Jovicić, S., Marković, B., Đukić, M.,& Radojković, D.. (2017). The Role of Oxidative Stress in the Clinical Manifestations of Childhood Asthma. in Fetal and Pediatric Pathology Taylor & Francis Inc, Philadelphia., 36(4), 294-303. https://doi.org/10.1080/15513815.2017.1315199
Topić A, Francuski D, Nikolić A, Milosević K, Jovicić S, Marković B, Đukić M, Radojković D. The Role of Oxidative Stress in the Clinical Manifestations of Childhood Asthma. in Fetal and Pediatric Pathology. 2017;36(4):294-303. doi:10.1080/15513815.2017.1315199 .
Topić, Aleksandra, Francuski, Djordje, Nikolić, Aleksandra, Milosević, Katarina, Jovicić, Snežana, Marković, Bojan, Đukić, Mirjana, Radojković, Dragica, "The Role of Oxidative Stress in the Clinical Manifestations of Childhood Asthma" in Fetal and Pediatric Pathology, 36, no. 4 (2017):294-303, https://doi.org/10.1080/15513815.2017.1315199 . .