Genetic and environmental factors significant for the presentation and development of inflammatory bowel disease
Нема приказа
Аутори
Dragasević, SanjaStanković, Biljana
Milosavljević, Tomica
Sokić-Milutinović, Aleksandra
Lukić, Snežana
Alempijević, Tamara
Zukić, Branka
Kotur, Nikola
Nikčević, Gordana
Pavlović, Sonja
Popović, Dragan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Objectives The aim of the study was to evaluate associations between inflammatory bowel disease (IBD) presentation and variants in NOD2, TLR4, TNF-alpha, IL-6, IL-1 beta, and IL-RN genes in order to identify possible environmental factors that may affect IBD occurrence, investigate potential predictors for surgical treatment of IBD, and correlate the presence of granulomas in biopsy specimens with clinical characteristics of Crohn's disease (CD) patients. Patients and methods We genotyped 167 IBD patients using PCR-based methodology and tested for disease genotype-phenotype associations. Results In CD patients ileal localization of disease was more frequent in NOD2 variant carriers. Ileal CD was associated with IL-6 GC+CC genotypes, identifying C allele as a possible marker of increased risk for ileal CD. In CD patients a positive family history for IBD was related to earlier onset of disease, higher risk for CD-related surgery, and appendectomy. CD patients who are TLR4 299Gly carrier...s are at higher risk for surgery at onset of the disease compared with TLR4 299Asp variant carriers. The presence of granuloma in biopsy specimens was more frequent in patients in whom a diagnosis of CD was made during emergency surgery. Multivariate analysis showed that CD carriers of the 299Gly allele had a 4.6-fold higher risk for emergency surgery before CD diagnosis is established compared with noncarriers, suggesting an aggressive disease course. Granuloma in endoscopic biopsies is detected 5.4-fold more frequently in patients treated surgically at the time of diagnosis. Conclusion Genetic variants together with epidemiological and clinical data of IBD patients could potentially be used as predictors of the disease course.
Кључне речи:
prognosis / phenotypic heterogeneity / inflammatory bowel disease / genetic variantsИзвор:
European Journal of Gastroenterology & Hepatology, 2017, 29, 8, 909-915Издавач:
- Lippincott Williams & Wilkins, Philadelphia
Финансирање / пројекти:
- Ретке болести: молекуларна патофизиологија, дијагностички и терапијски модалитети и социјални, етички и правни аспекти (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41004)
DOI: 10.1097/MEG.0000000000000877
ISSN: 0954-691X
PubMed: 28452812
WoS: 000405092100007
Scopus: 2-s2.0-85023182529
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Dragasević, Sanja AU - Stanković, Biljana AU - Milosavljević, Tomica AU - Sokić-Milutinović, Aleksandra AU - Lukić, Snežana AU - Alempijević, Tamara AU - Zukić, Branka AU - Kotur, Nikola AU - Nikčević, Gordana AU - Pavlović, Sonja AU - Popović, Dragan PY - 2017 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1063 AB - Objectives The aim of the study was to evaluate associations between inflammatory bowel disease (IBD) presentation and variants in NOD2, TLR4, TNF-alpha, IL-6, IL-1 beta, and IL-RN genes in order to identify possible environmental factors that may affect IBD occurrence, investigate potential predictors for surgical treatment of IBD, and correlate the presence of granulomas in biopsy specimens with clinical characteristics of Crohn's disease (CD) patients. Patients and methods We genotyped 167 IBD patients using PCR-based methodology and tested for disease genotype-phenotype associations. Results In CD patients ileal localization of disease was more frequent in NOD2 variant carriers. Ileal CD was associated with IL-6 GC+CC genotypes, identifying C allele as a possible marker of increased risk for ileal CD. In CD patients a positive family history for IBD was related to earlier onset of disease, higher risk for CD-related surgery, and appendectomy. CD patients who are TLR4 299Gly carriers are at higher risk for surgery at onset of the disease compared with TLR4 299Asp variant carriers. The presence of granuloma in biopsy specimens was more frequent in patients in whom a diagnosis of CD was made during emergency surgery. Multivariate analysis showed that CD carriers of the 299Gly allele had a 4.6-fold higher risk for emergency surgery before CD diagnosis is established compared with noncarriers, suggesting an aggressive disease course. Granuloma in endoscopic biopsies is detected 5.4-fold more frequently in patients treated surgically at the time of diagnosis. Conclusion Genetic variants together with epidemiological and clinical data of IBD patients could potentially be used as predictors of the disease course. PB - Lippincott Williams & Wilkins, Philadelphia T2 - European Journal of Gastroenterology & Hepatology T1 - Genetic and environmental factors significant for the presentation and development of inflammatory bowel disease EP - 915 IS - 8 SP - 909 VL - 29 DO - 10.1097/MEG.0000000000000877 ER -
@article{ author = "Dragasević, Sanja and Stanković, Biljana and Milosavljević, Tomica and Sokić-Milutinović, Aleksandra and Lukić, Snežana and Alempijević, Tamara and Zukić, Branka and Kotur, Nikola and Nikčević, Gordana and Pavlović, Sonja and Popović, Dragan", year = "2017", abstract = "Objectives The aim of the study was to evaluate associations between inflammatory bowel disease (IBD) presentation and variants in NOD2, TLR4, TNF-alpha, IL-6, IL-1 beta, and IL-RN genes in order to identify possible environmental factors that may affect IBD occurrence, investigate potential predictors for surgical treatment of IBD, and correlate the presence of granulomas in biopsy specimens with clinical characteristics of Crohn's disease (CD) patients. Patients and methods We genotyped 167 IBD patients using PCR-based methodology and tested for disease genotype-phenotype associations. Results In CD patients ileal localization of disease was more frequent in NOD2 variant carriers. Ileal CD was associated with IL-6 GC+CC genotypes, identifying C allele as a possible marker of increased risk for ileal CD. In CD patients a positive family history for IBD was related to earlier onset of disease, higher risk for CD-related surgery, and appendectomy. CD patients who are TLR4 299Gly carriers are at higher risk for surgery at onset of the disease compared with TLR4 299Asp variant carriers. The presence of granuloma in biopsy specimens was more frequent in patients in whom a diagnosis of CD was made during emergency surgery. Multivariate analysis showed that CD carriers of the 299Gly allele had a 4.6-fold higher risk for emergency surgery before CD diagnosis is established compared with noncarriers, suggesting an aggressive disease course. Granuloma in endoscopic biopsies is detected 5.4-fold more frequently in patients treated surgically at the time of diagnosis. Conclusion Genetic variants together with epidemiological and clinical data of IBD patients could potentially be used as predictors of the disease course.", publisher = "Lippincott Williams & Wilkins, Philadelphia", journal = "European Journal of Gastroenterology & Hepatology", title = "Genetic and environmental factors significant for the presentation and development of inflammatory bowel disease", pages = "915-909", number = "8", volume = "29", doi = "10.1097/MEG.0000000000000877" }
Dragasević, S., Stanković, B., Milosavljević, T., Sokić-Milutinović, A., Lukić, S., Alempijević, T., Zukić, B., Kotur, N., Nikčević, G., Pavlović, S.,& Popović, D.. (2017). Genetic and environmental factors significant for the presentation and development of inflammatory bowel disease. in European Journal of Gastroenterology & Hepatology Lippincott Williams & Wilkins, Philadelphia., 29(8), 909-915. https://doi.org/10.1097/MEG.0000000000000877
Dragasević S, Stanković B, Milosavljević T, Sokić-Milutinović A, Lukić S, Alempijević T, Zukić B, Kotur N, Nikčević G, Pavlović S, Popović D. Genetic and environmental factors significant for the presentation and development of inflammatory bowel disease. in European Journal of Gastroenterology & Hepatology. 2017;29(8):909-915. doi:10.1097/MEG.0000000000000877 .
Dragasević, Sanja, Stanković, Biljana, Milosavljević, Tomica, Sokić-Milutinović, Aleksandra, Lukić, Snežana, Alempijević, Tamara, Zukić, Branka, Kotur, Nikola, Nikčević, Gordana, Pavlović, Sonja, Popović, Dragan, "Genetic and environmental factors significant for the presentation and development of inflammatory bowel disease" in European Journal of Gastroenterology & Hepatology, 29, no. 8 (2017):909-915, https://doi.org/10.1097/MEG.0000000000000877 . .