Early onset of abdominal venous thrombosis in a newborn with homozygous type II heparin-binding site antithrombin deficiency
Само за регистроване кориснике
2017
Аутори
Kovač, MirjanaMitić, Gorana
Jesić, Milos
Đorđević, Valentina
Muszbek, Laszlo
Bereczky, Zsuzsanna
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The overall incidence of thromboembolic events in the neonatal period is 5 per 100 000 births, wherein more than 40% of all such manifestations are symptomatic renal vein thromboses. We describe the case of a newborn female who developed extensive thrombosis, which filled the inferior vena cava and renal vein and was diagnosed in the first weeks of life. A homozygous type II heparin-binding site antithrombin deficiency (c.391C gt T, p.Leu131Phe) was detected in the background. Despite the timely diagnosis and appropriate treatment, clinical signs of renal insufficiency, because of left kidney atrophy and arterial hypertension, were observed. Our case demonstrates the seriousness of the consequences arising after early onset of venous thrombosis caused by homozygous type II heparin-binding site antithrombin deficiency. In addition to prompt diagnosis, of huge importance is the determination of inherited thrombophilia, as it significantly affects therapeutic treatment and indicates that ...long-term follow-up is mandatory.
Кључне речи:
antithrombin deficiency Budapest 3 / abdominal venous thrombosisИзвор:
Blood Coagulation & Fibrinolysis, 2017, 28, 3, 264-266Издавач:
- Lippincott Williams & Wilkins, Philadelphia
Финансирање / пројекти:
- Комплексне болести као модел систем за проучавање модулације фенотипа-структурна и функционална анализа молекуларних биомаркера (RS-MESTD-Basic Research (BR or ON)-173008)
- Hungarian National Research Fund [OTKA PD101120, K116228]
DOI: 10.1097/MBC.0000000000000570
ISSN: 0957-5235
PubMed: 27214036
WoS: 000399383700012
Scopus: 2-s2.0-84969794065
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Kovač, Mirjana AU - Mitić, Gorana AU - Jesić, Milos AU - Đorđević, Valentina AU - Muszbek, Laszlo AU - Bereczky, Zsuzsanna PY - 2017 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1072 AB - The overall incidence of thromboembolic events in the neonatal period is 5 per 100 000 births, wherein more than 40% of all such manifestations are symptomatic renal vein thromboses. We describe the case of a newborn female who developed extensive thrombosis, which filled the inferior vena cava and renal vein and was diagnosed in the first weeks of life. A homozygous type II heparin-binding site antithrombin deficiency (c.391C gt T, p.Leu131Phe) was detected in the background. Despite the timely diagnosis and appropriate treatment, clinical signs of renal insufficiency, because of left kidney atrophy and arterial hypertension, were observed. Our case demonstrates the seriousness of the consequences arising after early onset of venous thrombosis caused by homozygous type II heparin-binding site antithrombin deficiency. In addition to prompt diagnosis, of huge importance is the determination of inherited thrombophilia, as it significantly affects therapeutic treatment and indicates that long-term follow-up is mandatory. PB - Lippincott Williams & Wilkins, Philadelphia T2 - Blood Coagulation & Fibrinolysis T1 - Early onset of abdominal venous thrombosis in a newborn with homozygous type II heparin-binding site antithrombin deficiency EP - 266 IS - 3 SP - 264 VL - 28 DO - 10.1097/MBC.0000000000000570 ER -
@article{ author = "Kovač, Mirjana and Mitić, Gorana and Jesić, Milos and Đorđević, Valentina and Muszbek, Laszlo and Bereczky, Zsuzsanna", year = "2017", abstract = "The overall incidence of thromboembolic events in the neonatal period is 5 per 100 000 births, wherein more than 40% of all such manifestations are symptomatic renal vein thromboses. We describe the case of a newborn female who developed extensive thrombosis, which filled the inferior vena cava and renal vein and was diagnosed in the first weeks of life. A homozygous type II heparin-binding site antithrombin deficiency (c.391C gt T, p.Leu131Phe) was detected in the background. Despite the timely diagnosis and appropriate treatment, clinical signs of renal insufficiency, because of left kidney atrophy and arterial hypertension, were observed. Our case demonstrates the seriousness of the consequences arising after early onset of venous thrombosis caused by homozygous type II heparin-binding site antithrombin deficiency. In addition to prompt diagnosis, of huge importance is the determination of inherited thrombophilia, as it significantly affects therapeutic treatment and indicates that long-term follow-up is mandatory.", publisher = "Lippincott Williams & Wilkins, Philadelphia", journal = "Blood Coagulation & Fibrinolysis", title = "Early onset of abdominal venous thrombosis in a newborn with homozygous type II heparin-binding site antithrombin deficiency", pages = "266-264", number = "3", volume = "28", doi = "10.1097/MBC.0000000000000570" }
Kovač, M., Mitić, G., Jesić, M., Đorđević, V., Muszbek, L.,& Bereczky, Z.. (2017). Early onset of abdominal venous thrombosis in a newborn with homozygous type II heparin-binding site antithrombin deficiency. in Blood Coagulation & Fibrinolysis Lippincott Williams & Wilkins, Philadelphia., 28(3), 264-266. https://doi.org/10.1097/MBC.0000000000000570
Kovač M, Mitić G, Jesić M, Đorđević V, Muszbek L, Bereczky Z. Early onset of abdominal venous thrombosis in a newborn with homozygous type II heparin-binding site antithrombin deficiency. in Blood Coagulation & Fibrinolysis. 2017;28(3):264-266. doi:10.1097/MBC.0000000000000570 .
Kovač, Mirjana, Mitić, Gorana, Jesić, Milos, Đorđević, Valentina, Muszbek, Laszlo, Bereczky, Zsuzsanna, "Early onset of abdominal venous thrombosis in a newborn with homozygous type II heparin-binding site antithrombin deficiency" in Blood Coagulation & Fibrinolysis, 28, no. 3 (2017):264-266, https://doi.org/10.1097/MBC.0000000000000570 . .