In vitro antimicrobial activity and cytotoxicity of nickel(II) complexes with different diamine ligands
Authors
Drasković, Nenad S.Glišić, Biljana
Vojnović, Sandra
Nikodinović-Runić, Jasmina
Djuran, Milos I.
Article (Published version)
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Three diamines, 1,3-propanediamine (1,3-pd), 2,2-dimethyl-1,3-propanediamine (2,2-diMe-1,3-pd) and (+/-)-1,3-pentanediamine (1,3-pnd), were used for the synthesis of nickel(II) complexes 1-3, respectively, of the general formula [Ni(L)(2)(H2O)(2)]Cl-2. The stoichiometries of the complexes were confirmed by elemental microanalysis, and their structures were elucidated by spectroscopic (UV-Vis and IR) and molar conductivity measurements. The complexes 1-3, along with NiCl2 center dot 6H(2)O and the diamine ligands, were evaluated against a panel of microbial strains that are associated with skin, wound, urinary tract and nosocomial infections. The obtained results revealed no significant activity of 1-3 against the investigated bacterial strains. On the other hand, they showed good antifungal activity against pathogenic Candida strains, with minimum inhibitory concentration (MIC) values in the range from 15.6 to 62.5 mu g mL(-1). The best anti-Candida activity was observed for complex 2 ...against C. parapsilosis, while the least susceptible to the effect of the complexes was C. krusei. The antiproliferative effect on normal human lung fibro-blast cell line MRC-5 was also evaluated in order to determine the therapeutic potential of nickel(II) complexes 1-3. These complexes showed lower negative effects on the viability of the MRC-5 cell line than the clinically used nystatin and comparable selectivity indexes to that of this antifungal drug.
Keywords:
nickel(II) complexes / diamines / cytotoxicity / Candida / antimicrobial activitySource:
Journal of the Serbian Chemical Society, 2017, 82, 4, 389-398Publisher:
- Srpsko hemijsko društvo, Beograd
Funding / projects:
- Synthesis of new metal complexes and investigation of their reactions with peptides (RS-MESTD-Basic Research (BR or ON)-172036)
- Microbial diversity study and characterization of beneficial environmental microorganisms (RS-MESTD-Basic Research (BR or ON)-173048)
DOI: 10.2298/JSC170113026D
ISSN: 0352-5139
WoS: 000404614300004
Scopus: 2-s2.0-85019366561
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Drasković, Nenad S. AU - Glišić, Biljana AU - Vojnović, Sandra AU - Nikodinović-Runić, Jasmina AU - Djuran, Milos I. PY - 2017 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1087 AB - Three diamines, 1,3-propanediamine (1,3-pd), 2,2-dimethyl-1,3-propanediamine (2,2-diMe-1,3-pd) and (+/-)-1,3-pentanediamine (1,3-pnd), were used for the synthesis of nickel(II) complexes 1-3, respectively, of the general formula [Ni(L)(2)(H2O)(2)]Cl-2. The stoichiometries of the complexes were confirmed by elemental microanalysis, and their structures were elucidated by spectroscopic (UV-Vis and IR) and molar conductivity measurements. The complexes 1-3, along with NiCl2 center dot 6H(2)O and the diamine ligands, were evaluated against a panel of microbial strains that are associated with skin, wound, urinary tract and nosocomial infections. The obtained results revealed no significant activity of 1-3 against the investigated bacterial strains. On the other hand, they showed good antifungal activity against pathogenic Candida strains, with minimum inhibitory concentration (MIC) values in the range from 15.6 to 62.5 mu g mL(-1). The best anti-Candida activity was observed for complex 2 against C. parapsilosis, while the least susceptible to the effect of the complexes was C. krusei. The antiproliferative effect on normal human lung fibro-blast cell line MRC-5 was also evaluated in order to determine the therapeutic potential of nickel(II) complexes 1-3. These complexes showed lower negative effects on the viability of the MRC-5 cell line than the clinically used nystatin and comparable selectivity indexes to that of this antifungal drug. PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - In vitro antimicrobial activity and cytotoxicity of nickel(II) complexes with different diamine ligands EP - 398 IS - 4 SP - 389 VL - 82 DO - 10.2298/JSC170113026D ER -
@article{ author = "Drasković, Nenad S. and Glišić, Biljana and Vojnović, Sandra and Nikodinović-Runić, Jasmina and Djuran, Milos I.", year = "2017", abstract = "Three diamines, 1,3-propanediamine (1,3-pd), 2,2-dimethyl-1,3-propanediamine (2,2-diMe-1,3-pd) and (+/-)-1,3-pentanediamine (1,3-pnd), were used for the synthesis of nickel(II) complexes 1-3, respectively, of the general formula [Ni(L)(2)(H2O)(2)]Cl-2. The stoichiometries of the complexes were confirmed by elemental microanalysis, and their structures were elucidated by spectroscopic (UV-Vis and IR) and molar conductivity measurements. The complexes 1-3, along with NiCl2 center dot 6H(2)O and the diamine ligands, were evaluated against a panel of microbial strains that are associated with skin, wound, urinary tract and nosocomial infections. The obtained results revealed no significant activity of 1-3 against the investigated bacterial strains. On the other hand, they showed good antifungal activity against pathogenic Candida strains, with minimum inhibitory concentration (MIC) values in the range from 15.6 to 62.5 mu g mL(-1). The best anti-Candida activity was observed for complex 2 against C. parapsilosis, while the least susceptible to the effect of the complexes was C. krusei. The antiproliferative effect on normal human lung fibro-blast cell line MRC-5 was also evaluated in order to determine the therapeutic potential of nickel(II) complexes 1-3. These complexes showed lower negative effects on the viability of the MRC-5 cell line than the clinically used nystatin and comparable selectivity indexes to that of this antifungal drug.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "In vitro antimicrobial activity and cytotoxicity of nickel(II) complexes with different diamine ligands", pages = "398-389", number = "4", volume = "82", doi = "10.2298/JSC170113026D" }
Drasković, N. S., Glišić, B., Vojnović, S., Nikodinović-Runić, J.,& Djuran, M. I.. (2017). In vitro antimicrobial activity and cytotoxicity of nickel(II) complexes with different diamine ligands. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 82(4), 389-398. https://doi.org/10.2298/JSC170113026D
Drasković NS, Glišić B, Vojnović S, Nikodinović-Runić J, Djuran MI. In vitro antimicrobial activity and cytotoxicity of nickel(II) complexes with different diamine ligands. in Journal of the Serbian Chemical Society. 2017;82(4):389-398. doi:10.2298/JSC170113026D .
Drasković, Nenad S., Glišić, Biljana, Vojnović, Sandra, Nikodinović-Runić, Jasmina, Djuran, Milos I., "In vitro antimicrobial activity and cytotoxicity of nickel(II) complexes with different diamine ligands" in Journal of the Serbian Chemical Society, 82, no. 4 (2017):389-398, https://doi.org/10.2298/JSC170113026D . .