Polymorphism RAD51 172G > T in Serbian patients with colorectal cancer
Само за регистроване кориснике
2018
Аутори
Petrović-Sunderić, JelenaDragičević, Sandra
Krnjajić, Mina
Ristanović, Momcilo
Nikolić, Aleksandra
Krivokapić, Zoran
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Purpose: The RAD51 gene plays an important role in homologous strand exchange in DNA repair. Two common single nucleotide polymorphisms in this gene, 135G gt C and 172G gt T, were associated with altered gene transcription. While 135G gt C was already linked to breast and colorectal cancers in certain populations, 172G gt T is far less investigated, although sporadic studies showed it could be a prognostic factor for some cancer lesions. The purpose of this study was to investigate RAD51 172G gt T polymorphism in Serbian population, its association with colorectal carcinoma, as well as correlation with disease characteristics and response to neoadjuvant chemoradiotherapy. Methods: The 172G gt T polymorphism was evaluated by PCR-RFLP method in blood samples of 209 colorectal cancer patients and 43 healthy subjects who served as controls. The distribution of genotypes was also analyzed in respect to several tumor characteristics in cases where histopathological data were avai...lable. Results: A significant association between the RAD51 172G gt T polymoprhism and desmoplastic reaction of colorectal cancer was demonstrated. The 172G allele was found to be significantly more frequent in patients with more intensive desmoplastic response of the tumor tissue. Conclusions: The results of our study suggest that the 172T allele of RAD51 may be a favorable prognostic factor in Serbian patients with colorectal cancer, although larger prospective studies are required to confirm this finding.
Кључне речи:
RAD51 / polymorphism / desmoplastic reaction / colorectal cancerИзвор:
Journal of Buon, 2018, 23, 4, 936-940Издавач:
- Balkan Union of Oncology (B.U.ON.)
Финансирање / пројекти:
- Улога преоперативног одређивања стадијума болести, прогностичких, терапијских маркера, објективизирање функционалних резултата у одлуци о стратегији лечења карцинома ректума, а у циљу унапређења онколошких резултата и квалитета живота (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41033)
Колекције
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Petrović-Sunderić, Jelena AU - Dragičević, Sandra AU - Krnjajić, Mina AU - Ristanović, Momcilo AU - Nikolić, Aleksandra AU - Krivokapić, Zoran PY - 2018 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1115 AB - Purpose: The RAD51 gene plays an important role in homologous strand exchange in DNA repair. Two common single nucleotide polymorphisms in this gene, 135G gt C and 172G gt T, were associated with altered gene transcription. While 135G gt C was already linked to breast and colorectal cancers in certain populations, 172G gt T is far less investigated, although sporadic studies showed it could be a prognostic factor for some cancer lesions. The purpose of this study was to investigate RAD51 172G gt T polymorphism in Serbian population, its association with colorectal carcinoma, as well as correlation with disease characteristics and response to neoadjuvant chemoradiotherapy. Methods: The 172G gt T polymorphism was evaluated by PCR-RFLP method in blood samples of 209 colorectal cancer patients and 43 healthy subjects who served as controls. The distribution of genotypes was also analyzed in respect to several tumor characteristics in cases where histopathological data were available. Results: A significant association between the RAD51 172G gt T polymoprhism and desmoplastic reaction of colorectal cancer was demonstrated. The 172G allele was found to be significantly more frequent in patients with more intensive desmoplastic response of the tumor tissue. Conclusions: The results of our study suggest that the 172T allele of RAD51 may be a favorable prognostic factor in Serbian patients with colorectal cancer, although larger prospective studies are required to confirm this finding. PB - Balkan Union of Oncology (B.U.ON.) T2 - Journal of Buon T1 - Polymorphism RAD51 172G > T in Serbian patients with colorectal cancer EP - 940 IS - 4 SP - 936 VL - 23 UR - https://hdl.handle.net/21.15107/rcub_imagine_1115 ER -
@article{ author = "Petrović-Sunderić, Jelena and Dragičević, Sandra and Krnjajić, Mina and Ristanović, Momcilo and Nikolić, Aleksandra and Krivokapić, Zoran", year = "2018", abstract = "Purpose: The RAD51 gene plays an important role in homologous strand exchange in DNA repair. Two common single nucleotide polymorphisms in this gene, 135G gt C and 172G gt T, were associated with altered gene transcription. While 135G gt C was already linked to breast and colorectal cancers in certain populations, 172G gt T is far less investigated, although sporadic studies showed it could be a prognostic factor for some cancer lesions. The purpose of this study was to investigate RAD51 172G gt T polymorphism in Serbian population, its association with colorectal carcinoma, as well as correlation with disease characteristics and response to neoadjuvant chemoradiotherapy. Methods: The 172G gt T polymorphism was evaluated by PCR-RFLP method in blood samples of 209 colorectal cancer patients and 43 healthy subjects who served as controls. The distribution of genotypes was also analyzed in respect to several tumor characteristics in cases where histopathological data were available. Results: A significant association between the RAD51 172G gt T polymoprhism and desmoplastic reaction of colorectal cancer was demonstrated. The 172G allele was found to be significantly more frequent in patients with more intensive desmoplastic response of the tumor tissue. Conclusions: The results of our study suggest that the 172T allele of RAD51 may be a favorable prognostic factor in Serbian patients with colorectal cancer, although larger prospective studies are required to confirm this finding.", publisher = "Balkan Union of Oncology (B.U.ON.)", journal = "Journal of Buon", title = "Polymorphism RAD51 172G > T in Serbian patients with colorectal cancer", pages = "940-936", number = "4", volume = "23", url = "https://hdl.handle.net/21.15107/rcub_imagine_1115" }
Petrović-Sunderić, J., Dragičević, S., Krnjajić, M., Ristanović, M., Nikolić, A.,& Krivokapić, Z.. (2018). Polymorphism RAD51 172G > T in Serbian patients with colorectal cancer. in Journal of Buon Balkan Union of Oncology (B.U.ON.)., 23(4), 936-940. https://hdl.handle.net/21.15107/rcub_imagine_1115
Petrović-Sunderić J, Dragičević S, Krnjajić M, Ristanović M, Nikolić A, Krivokapić Z. Polymorphism RAD51 172G > T in Serbian patients with colorectal cancer. in Journal of Buon. 2018;23(4):936-940. https://hdl.handle.net/21.15107/rcub_imagine_1115 .
Petrović-Sunderić, Jelena, Dragičević, Sandra, Krnjajić, Mina, Ristanović, Momcilo, Nikolić, Aleksandra, Krivokapić, Zoran, "Polymorphism RAD51 172G > T in Serbian patients with colorectal cancer" in Journal of Buon, 23, no. 4 (2018):936-940, https://hdl.handle.net/21.15107/rcub_imagine_1115 .