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Importance of TLR9-IL23-1L17 axis in inflammatory bowel disease development: Gene expression profiling study
dc.creator | Dragasević, Sanja | |
dc.creator | Stanković, Biljana | |
dc.creator | Sokić-Milutinović, Aleksandra | |
dc.creator | Milosavljević, Tomica | |
dc.creator | Milovanović, Tamara | |
dc.creator | Lukić, Snežana | |
dc.creator | Srzentić Dražilov, Sanja | |
dc.creator | Klaassen, Kristel | |
dc.creator | Kotur, Nikola | |
dc.creator | Pavlović, Sonja | |
dc.creator | Popović, Dragan | |
dc.date.accessioned | 2022-11-15T14:57:07Z | |
dc.date.available | 2019-12-01 | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1521-6616 | |
dc.identifier.uri | https://imagine.imgge.bg.ac.rs/handle/123456789/1123 | |
dc.description.abstract | Background and aims: Mucosal gene expression have not been fully enlightened in inflammatory bowel disease (IBD). Aim of this study was to define IL23A, IL17A, IL17F and TLR9 expression in different IBD phenotypes. Methods: Evaluation of mRNA levels was performed in paired non-inflamed and inflamed mucosal biopsies of newly diagnosed 50 Crohn's disease (CD) and 54 ulcerative colitis (UC) patients by quantitative real-time PCR analysis. Results: IL17A and IL17F expression levels were significantly increased in inflamed IBD mucosa. Inflamed CD ileal and UC mucosa showed increased IL23A, while only inflamed CD ileal samples showed increased TLR9 mRNA level. Correlation between analysed mRNAs levels and endoscopic and clinical disease activity were found in UC, but only with clinical activity in CD. Conclusion: Both CD and UC presented expression of Th17-associated genes. Nevertheless, expression profiles between different disease forms varies which should be taken into account for future research and therapeutics strategies. | en |
dc.publisher | Academic Press Inc Elsevier Science, San Diego | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41004/RS// | |
dc.relation.isversionof | https://doi.org/10.1016/j.clim.2018.09.001 | |
dc.rights | embargoedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Clinical Immunology | |
dc.subject | Inflammatory bowel disease | en |
dc.subject | IL23/IL17/TLR9 | en |
dc.subject | Expression profiling | en |
dc.title | Importance of TLR9-IL23-1L17 axis in inflammatory bowel disease development: Gene expression profiling study | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dc.citation.epage | 95 | |
dc.citation.other | 197(): 86-95 | |
dc.citation.rank | M22 | |
dc.citation.spage | 86 | |
dc.citation.volume | 197 | |
dc.description.other | This is the peer reviewed version of the paper: Dragasevic, S., Stankovic, B., Sokic-Milutinovic, A., Milosavljevic, T., Milovanovic, T., Lukic, S., Drazilov, S. S., Klaassen, K., Kotur, N., Pavlovic, S., & Popovic, D. (2018). Importance of TLR9-IL23-IL17 axis in inflammatory bowel disease development: Gene expression profiling study. Clinical Immunology, 197, 86–95. [https://doi.org/10.1016/j.clim.2018.09.001] | |
dc.identifier.doi | 10.1016/j.clim.2018.09.001 | |
dc.identifier.fulltext | https://imagine.imgge.bg.ac.rs/bitstream/id/11247/Peer_reviewed_version_Importance_of_TLR9-IL23-IL17_axis_in_inflammatory_bowel_disease_development_Gene_expression_profiling_study_2018.pdf | |
dc.identifier.pmid | 30193869 | |
dc.identifier.scopus | 2-s2.0-85053560716 | |
dc.identifier.wos | 000454372500012 | |
dc.type.version | acceptedVersion |