The predictive value of morphological findings in early diagnosis of acute myeloid leukemia with recurrent cytogenetic abnormalities
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Аутори
Jaković, LjubomirBogdanović, Andrija
Đorđević, Vesna
Denčić-Fekete, Marija
Kraguljac-Kurtović, Nada
Knezević, Vesna
Tošić, Nataša
Pavlović, Sonja
Terzić, Tatjana
Чланак у часопису (Објављена верзија)
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Приказ свих података о документуАпстракт
This study explores cytomorphologic features and their predictive role for early identification of acute myeloid leukemia (AML) with morphological distinctive recurrent cytogenetic abnormalities (RCA): t(15;17), t(8;21) and inv(16)/t(16;16). We retrospectively evaluated 396 de novo AML cases, diagnosed and treated at single institution, between 2013-2017. Specific cytomorphologic features suggesting distinctive AML-RCA were revealed at diagnosis in 62 (15.65%) patients, including AML with t(15;17) in 41 (66.13%), t(8;21) in 13 (20.97%) and inv(16)/t(16;16) in 8 (12.90%). Final diagnoses of AML-RCA according to WHO integrated diagnostic criteria were established in 66 (16.66%) cases, including AML with t(15;17) 40 (60.60%), t(8;21) 17 (25.76%), and inv(16)/t(16;16) 9 (13.64%). Discordance between cytomorphological and other integrated criteria was detected as missed/wrong-call in 0/1 for t(15;17), 6/2 for t(8;21) and 2/1 for inv(16)/t(16;16). The cytomorphological accuracy was 97.56% (4...0/41) for t(15;17), 57.89% (11/19) for t(8;21) and 70% (7/10) for inv (16)/t(16;16). Positive/negative predictive values of cytomorphological evaluation were: 97.56%/100% for t(15;17); 84.62%/88.68% for t(8;21);87.50%/96.65% for inv(16)/t(16;16). Sensitivity/specificity were: 100%/96.15% for t(15;17);64.10%/95.92% for t(8;21);77.78%/98.25% for inv(16)/t(16;16). We confirmed that morphology is still a highly relevant evaluation method in diagnosing several common AML-RCAs before completing cytogenetic and molecular studies, enabling early detection, particularly of AML with t(15;17).
Кључне речи:
WHO classification / Recurrent cytogenetic abnormalities / Cytomorphological characteristics / Acute myeloid leukemiaИзвор:
Leukemia Research, 2018, 75, 23-28Издавач:
- Pergamon-Elsevier Science Ltd, Oxford
Финансирање / пројекти:
- Ретке болести: молекуларна патофизиологија, дијагностички и терапијски модалитети и социјални, етички и правни аспекти (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41004)
DOI: 10.1016/j.leukres.2018.10.017
ISSN: 0145-2126
PubMed: 30445236
WoS: 000451068500005
Scopus: 2-s2.0-85056468477
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Jaković, Ljubomir AU - Bogdanović, Andrija AU - Đorđević, Vesna AU - Denčić-Fekete, Marija AU - Kraguljac-Kurtović, Nada AU - Knezević, Vesna AU - Tošić, Nataša AU - Pavlović, Sonja AU - Terzić, Tatjana PY - 2018 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1126 AB - This study explores cytomorphologic features and their predictive role for early identification of acute myeloid leukemia (AML) with morphological distinctive recurrent cytogenetic abnormalities (RCA): t(15;17), t(8;21) and inv(16)/t(16;16). We retrospectively evaluated 396 de novo AML cases, diagnosed and treated at single institution, between 2013-2017. Specific cytomorphologic features suggesting distinctive AML-RCA were revealed at diagnosis in 62 (15.65%) patients, including AML with t(15;17) in 41 (66.13%), t(8;21) in 13 (20.97%) and inv(16)/t(16;16) in 8 (12.90%). Final diagnoses of AML-RCA according to WHO integrated diagnostic criteria were established in 66 (16.66%) cases, including AML with t(15;17) 40 (60.60%), t(8;21) 17 (25.76%), and inv(16)/t(16;16) 9 (13.64%). Discordance between cytomorphological and other integrated criteria was detected as missed/wrong-call in 0/1 for t(15;17), 6/2 for t(8;21) and 2/1 for inv(16)/t(16;16). The cytomorphological accuracy was 97.56% (40/41) for t(15;17), 57.89% (11/19) for t(8;21) and 70% (7/10) for inv (16)/t(16;16). Positive/negative predictive values of cytomorphological evaluation were: 97.56%/100% for t(15;17); 84.62%/88.68% for t(8;21);87.50%/96.65% for inv(16)/t(16;16). Sensitivity/specificity were: 100%/96.15% for t(15;17);64.10%/95.92% for t(8;21);77.78%/98.25% for inv(16)/t(16;16). We confirmed that morphology is still a highly relevant evaluation method in diagnosing several common AML-RCAs before completing cytogenetic and molecular studies, enabling early detection, particularly of AML with t(15;17). PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Leukemia Research T1 - The predictive value of morphological findings in early diagnosis of acute myeloid leukemia with recurrent cytogenetic abnormalities EP - 28 SP - 23 VL - 75 DO - 10.1016/j.leukres.2018.10.017 ER -
@article{ author = "Jaković, Ljubomir and Bogdanović, Andrija and Đorđević, Vesna and Denčić-Fekete, Marija and Kraguljac-Kurtović, Nada and Knezević, Vesna and Tošić, Nataša and Pavlović, Sonja and Terzić, Tatjana", year = "2018", abstract = "This study explores cytomorphologic features and their predictive role for early identification of acute myeloid leukemia (AML) with morphological distinctive recurrent cytogenetic abnormalities (RCA): t(15;17), t(8;21) and inv(16)/t(16;16). We retrospectively evaluated 396 de novo AML cases, diagnosed and treated at single institution, between 2013-2017. Specific cytomorphologic features suggesting distinctive AML-RCA were revealed at diagnosis in 62 (15.65%) patients, including AML with t(15;17) in 41 (66.13%), t(8;21) in 13 (20.97%) and inv(16)/t(16;16) in 8 (12.90%). Final diagnoses of AML-RCA according to WHO integrated diagnostic criteria were established in 66 (16.66%) cases, including AML with t(15;17) 40 (60.60%), t(8;21) 17 (25.76%), and inv(16)/t(16;16) 9 (13.64%). Discordance between cytomorphological and other integrated criteria was detected as missed/wrong-call in 0/1 for t(15;17), 6/2 for t(8;21) and 2/1 for inv(16)/t(16;16). The cytomorphological accuracy was 97.56% (40/41) for t(15;17), 57.89% (11/19) for t(8;21) and 70% (7/10) for inv (16)/t(16;16). Positive/negative predictive values of cytomorphological evaluation were: 97.56%/100% for t(15;17); 84.62%/88.68% for t(8;21);87.50%/96.65% for inv(16)/t(16;16). Sensitivity/specificity were: 100%/96.15% for t(15;17);64.10%/95.92% for t(8;21);77.78%/98.25% for inv(16)/t(16;16). We confirmed that morphology is still a highly relevant evaluation method in diagnosing several common AML-RCAs before completing cytogenetic and molecular studies, enabling early detection, particularly of AML with t(15;17).", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Leukemia Research", title = "The predictive value of morphological findings in early diagnosis of acute myeloid leukemia with recurrent cytogenetic abnormalities", pages = "28-23", volume = "75", doi = "10.1016/j.leukres.2018.10.017" }
Jaković, L., Bogdanović, A., Đorđević, V., Denčić-Fekete, M., Kraguljac-Kurtović, N., Knezević, V., Tošić, N., Pavlović, S.,& Terzić, T.. (2018). The predictive value of morphological findings in early diagnosis of acute myeloid leukemia with recurrent cytogenetic abnormalities. in Leukemia Research Pergamon-Elsevier Science Ltd, Oxford., 75, 23-28. https://doi.org/10.1016/j.leukres.2018.10.017
Jaković L, Bogdanović A, Đorđević V, Denčić-Fekete M, Kraguljac-Kurtović N, Knezević V, Tošić N, Pavlović S, Terzić T. The predictive value of morphological findings in early diagnosis of acute myeloid leukemia with recurrent cytogenetic abnormalities. in Leukemia Research. 2018;75:23-28. doi:10.1016/j.leukres.2018.10.017 .
Jaković, Ljubomir, Bogdanović, Andrija, Đorđević, Vesna, Denčić-Fekete, Marija, Kraguljac-Kurtović, Nada, Knezević, Vesna, Tošić, Nataša, Pavlović, Sonja, Terzić, Tatjana, "The predictive value of morphological findings in early diagnosis of acute myeloid leukemia with recurrent cytogenetic abnormalities" in Leukemia Research, 75 (2018):23-28, https://doi.org/10.1016/j.leukres.2018.10.017 . .