Characterisation and mapping of the human SOX14 gene
Abstract
SOX genes comprise a family of genes that are related to the mammalian sex determining gene SRY in the region that encodes the HMG-box domain responsible for the sequence-specific DNA-binding activity. SOX genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. We have cloned and characterised SOX14, a novel member of the human SOX gene family. Based on the HMG-box sequence, human SOX14 is a member of the B subfamily. SOX 14 is expressed in human foetal brain, spinal cord and thymus, and like other members of the B subfamily, it might have a role in regulation of nervous system development. While other members of the B subfamily show similarity outside the HMG-box, the regions flanking the HMG box of the human SOX14 gene are unique. SOX14 has been mapped to human chromosome 3q22 -- gt q23, close to the marker D3S1549. This location places SOX 14 within a chromosome interval associa...ted with two distinct syndromes that affect craniofacial development: Blepharophimosis-ptosis-epicantus inversus syndrome and Mobius syndrome.
Source:
Cytogenetics and Cell Genetics, 1998, 83, 1-2, 139-146Publisher:
- Karger, Basel
DOI: 10.1159/000015149
ISSN: 0301-0171
PubMed: 9925951
WoS: 000078544000044
Scopus: 2-s2.0-0032426887
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Arsić, N AU - Rajić, T AU - Stanojcić, S AU - Goodfellow, PN AU - Stevanović, Milena PY - 1998 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/113 AB - SOX genes comprise a family of genes that are related to the mammalian sex determining gene SRY in the region that encodes the HMG-box domain responsible for the sequence-specific DNA-binding activity. SOX genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. We have cloned and characterised SOX14, a novel member of the human SOX gene family. Based on the HMG-box sequence, human SOX14 is a member of the B subfamily. SOX 14 is expressed in human foetal brain, spinal cord and thymus, and like other members of the B subfamily, it might have a role in regulation of nervous system development. While other members of the B subfamily show similarity outside the HMG-box, the regions flanking the HMG box of the human SOX14 gene are unique. SOX14 has been mapped to human chromosome 3q22 -- gt q23, close to the marker D3S1549. This location places SOX 14 within a chromosome interval associated with two distinct syndromes that affect craniofacial development: Blepharophimosis-ptosis-epicantus inversus syndrome and Mobius syndrome. PB - Karger, Basel T2 - Cytogenetics and Cell Genetics T1 - Characterisation and mapping of the human SOX14 gene EP - 146 IS - 1-2 SP - 139 VL - 83 DO - 10.1159/000015149 ER -
@article{ author = "Arsić, N and Rajić, T and Stanojcić, S and Goodfellow, PN and Stevanović, Milena", year = "1998", abstract = "SOX genes comprise a family of genes that are related to the mammalian sex determining gene SRY in the region that encodes the HMG-box domain responsible for the sequence-specific DNA-binding activity. SOX genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. We have cloned and characterised SOX14, a novel member of the human SOX gene family. Based on the HMG-box sequence, human SOX14 is a member of the B subfamily. SOX 14 is expressed in human foetal brain, spinal cord and thymus, and like other members of the B subfamily, it might have a role in regulation of nervous system development. While other members of the B subfamily show similarity outside the HMG-box, the regions flanking the HMG box of the human SOX14 gene are unique. SOX14 has been mapped to human chromosome 3q22 -- gt q23, close to the marker D3S1549. This location places SOX 14 within a chromosome interval associated with two distinct syndromes that affect craniofacial development: Blepharophimosis-ptosis-epicantus inversus syndrome and Mobius syndrome.", publisher = "Karger, Basel", journal = "Cytogenetics and Cell Genetics", title = "Characterisation and mapping of the human SOX14 gene", pages = "146-139", number = "1-2", volume = "83", doi = "10.1159/000015149" }
Arsić, N., Rajić, T., Stanojcić, S., Goodfellow, P.,& Stevanović, M.. (1998). Characterisation and mapping of the human SOX14 gene. in Cytogenetics and Cell Genetics Karger, Basel., 83(1-2), 139-146. https://doi.org/10.1159/000015149
Arsić N, Rajić T, Stanojcić S, Goodfellow P, Stevanović M. Characterisation and mapping of the human SOX14 gene. in Cytogenetics and Cell Genetics. 1998;83(1-2):139-146. doi:10.1159/000015149 .
Arsić, N, Rajić, T, Stanojcić, S, Goodfellow, PN, Stevanović, Milena, "Characterisation and mapping of the human SOX14 gene" in Cytogenetics and Cell Genetics, 83, no. 1-2 (1998):139-146, https://doi.org/10.1159/000015149 . .