Oral treatment with Lactobacillus rhamnosus 64 during the early postnatal period improves the health of adult rats with TNBS-induced colitis
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2018
Authors
Stanojević, StanislavaBlagojević, Veljko
Curuvija, Ivana
Veljović, Katarina
Soković Bajić, Svetlana
Kotur-Stevuljević, Jelena
Bogdanović, Andrija
Petrović, Raisa
Vujnović, Ivana
Kovacević-Jovanović, Vesna
Article (Published version)
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The current study investigated a potential modulating effect of orally applied Lactobacillus rhamnosus 64 (LB64) during the early postnatal period (day of life: similar to 3-30), during young adult period (day of life: 31-70) or throughout experiment, on parameters of trinitrobenzenesulfonic acid (TNBS)-induced colitis in adult rats. Treatment with LB64 during early postnatal, but not during young adult period reduced clinical damage score, neutrophil and macrophage infiltration into colon, the level of cytokine and myeloperoxidase (MPO) activity, but had no influence on other parameters of oxidative damage. Early postnatal treatment with LB64 also increased the diversity of fecal Bifidobacteria and Eubacteria, and improved maturation of ileal villi in 30-days old rats. When LB64 is applied during a critical period early in life, it affects immune system functioning of adults, probably by interactions with the mucosal immune system of the gastrointestinal tract that provides immune sys...tem maturation and shapes the overall immune response.
Keywords:
TNBS-induced colitis / Rats / Microbiota diversity / Lactobacillus rhamnosus 64 / Early postnatal treatmentSource:
Journal of Functional Foods, 2018, 48, 92-105Publisher:
- Elsevier Science Bv, Amsterdam
Funding / projects:
- Immune system plasticity during aging: Immunomodulatory capacity of oestrogens (RS-MESTD-Basic Research (BR or ON)-175050)
DOI: 10.1016/j.jff.2018.07.014
ISSN: 1756-4646
WoS: 000447573600010
Scopus: 2-s2.0-85049437192
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Stanojević, Stanislava AU - Blagojević, Veljko AU - Curuvija, Ivana AU - Veljović, Katarina AU - Soković Bajić, Svetlana AU - Kotur-Stevuljević, Jelena AU - Bogdanović, Andrija AU - Petrović, Raisa AU - Vujnović, Ivana AU - Kovacević-Jovanović, Vesna PY - 2018 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1149 AB - The current study investigated a potential modulating effect of orally applied Lactobacillus rhamnosus 64 (LB64) during the early postnatal period (day of life: similar to 3-30), during young adult period (day of life: 31-70) or throughout experiment, on parameters of trinitrobenzenesulfonic acid (TNBS)-induced colitis in adult rats. Treatment with LB64 during early postnatal, but not during young adult period reduced clinical damage score, neutrophil and macrophage infiltration into colon, the level of cytokine and myeloperoxidase (MPO) activity, but had no influence on other parameters of oxidative damage. Early postnatal treatment with LB64 also increased the diversity of fecal Bifidobacteria and Eubacteria, and improved maturation of ileal villi in 30-days old rats. When LB64 is applied during a critical period early in life, it affects immune system functioning of adults, probably by interactions with the mucosal immune system of the gastrointestinal tract that provides immune system maturation and shapes the overall immune response. PB - Elsevier Science Bv, Amsterdam T2 - Journal of Functional Foods T1 - Oral treatment with Lactobacillus rhamnosus 64 during the early postnatal period improves the health of adult rats with TNBS-induced colitis EP - 105 SP - 92 VL - 48 DO - 10.1016/j.jff.2018.07.014 ER -
@article{ author = "Stanojević, Stanislava and Blagojević, Veljko and Curuvija, Ivana and Veljović, Katarina and Soković Bajić, Svetlana and Kotur-Stevuljević, Jelena and Bogdanović, Andrija and Petrović, Raisa and Vujnović, Ivana and Kovacević-Jovanović, Vesna", year = "2018", abstract = "The current study investigated a potential modulating effect of orally applied Lactobacillus rhamnosus 64 (LB64) during the early postnatal period (day of life: similar to 3-30), during young adult period (day of life: 31-70) or throughout experiment, on parameters of trinitrobenzenesulfonic acid (TNBS)-induced colitis in adult rats. Treatment with LB64 during early postnatal, but not during young adult period reduced clinical damage score, neutrophil and macrophage infiltration into colon, the level of cytokine and myeloperoxidase (MPO) activity, but had no influence on other parameters of oxidative damage. Early postnatal treatment with LB64 also increased the diversity of fecal Bifidobacteria and Eubacteria, and improved maturation of ileal villi in 30-days old rats. When LB64 is applied during a critical period early in life, it affects immune system functioning of adults, probably by interactions with the mucosal immune system of the gastrointestinal tract that provides immune system maturation and shapes the overall immune response.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Journal of Functional Foods", title = "Oral treatment with Lactobacillus rhamnosus 64 during the early postnatal period improves the health of adult rats with TNBS-induced colitis", pages = "105-92", volume = "48", doi = "10.1016/j.jff.2018.07.014" }
Stanojević, S., Blagojević, V., Curuvija, I., Veljović, K., Soković Bajić, S., Kotur-Stevuljević, J., Bogdanović, A., Petrović, R., Vujnović, I.,& Kovacević-Jovanović, V.. (2018). Oral treatment with Lactobacillus rhamnosus 64 during the early postnatal period improves the health of adult rats with TNBS-induced colitis. in Journal of Functional Foods Elsevier Science Bv, Amsterdam., 48, 92-105. https://doi.org/10.1016/j.jff.2018.07.014
Stanojević S, Blagojević V, Curuvija I, Veljović K, Soković Bajić S, Kotur-Stevuljević J, Bogdanović A, Petrović R, Vujnović I, Kovacević-Jovanović V. Oral treatment with Lactobacillus rhamnosus 64 during the early postnatal period improves the health of adult rats with TNBS-induced colitis. in Journal of Functional Foods. 2018;48:92-105. doi:10.1016/j.jff.2018.07.014 .
Stanojević, Stanislava, Blagojević, Veljko, Curuvija, Ivana, Veljović, Katarina, Soković Bajić, Svetlana, Kotur-Stevuljević, Jelena, Bogdanović, Andrija, Petrović, Raisa, Vujnović, Ivana, Kovacević-Jovanović, Vesna, "Oral treatment with Lactobacillus rhamnosus 64 during the early postnatal period improves the health of adult rats with TNBS-induced colitis" in Journal of Functional Foods, 48 (2018):92-105, https://doi.org/10.1016/j.jff.2018.07.014 . .