dc.creator | Jovicić, N. | |
dc.creator | Babić, Tamara | |
dc.creator | Dragičević, Sandra | |
dc.creator | Nestorović, B. | |
dc.creator | Nikolić, Aleksandra | |
dc.date.accessioned | 2022-11-15T14:59:21Z | |
dc.date.available | 2022-11-15T14:59:21Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1311-0160 | |
dc.identifier.uri | https://imagine.imgge.bg.ac.rs/handle/123456789/1152 | |
dc.description.abstract | Inhaled beta 2 adrenergic receptor (beta 2-AR) agonists are the mainstay of asthma therapy. The beta 2-AR protein is encoded by the ADRB2 gene and variants within this gene can have significant consequences for modulating the response to asthma therapy. This cross-sectional study performed at the University Children's Hospital in Belgrade, included 54 children with asthma. The subjects were genotyped for ADRB2 +46A gt G (Arg16Gly, rs1042713) and +79C gt G (G1n27G1u, rs1042714) polymorphisms and the association with asthma severity and response to inhaled salbutamol was examined. In Serbian asthmatic children, allele +46A was detected with a frequency of 41.7% and allele +79G was detected with a frequency of 23.1%. Allele +460 was found to be associated with a better response to inhaled salbutamol (p lt 0.05) and with mild form of asthma (p lt 0.05). Polymorphism ADRB2 +46A gt G may be a determinant of asthma severity and response to salbutamol in children with asthma. We did not find any association of +79C gt G polymorphisms with the asthma severity and bronchodilator response to inhaled salbutamol. The results of this study can be potentially useful for personalization of asthma treatment. | en |
dc.publisher | Macedonian Acad Sciences Arts, Skopje | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Balkan Journal of Medical Genetics | |
dc.subject | Polymorphism | en |
dc.subject | Bronchodilatator response | en |
dc.subject | Asthma | en |
dc.subject | ADRB2 gene | en |
dc.title | ADRB2 Gene Polymorphisms and Salbutamol Responsiveness in Serbian Children with Asthma | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dc.citation.epage | 38 | |
dc.citation.issue | 1 | |
dc.citation.other | 21(1): 33-38 | |
dc.citation.rank | M23 | |
dc.citation.spage | 33 | |
dc.citation.volume | 21 | |
dc.identifier.doi | 10.2478/bjmg-2018-0007 | |
dc.identifier.fulltext | https://imagine.imgge.bg.ac.rs/bitstream/id/78675/Adrb2_gene_polymorphisms_and_salbutamol_responsiveness_in_Serbian_children_with_asthma_2018.pdf | |
dc.identifier.scopus | 2-s2.0-85056127673 | |
dc.identifier.wos | 000448827400005 | |
dc.type.version | publishedVersion | |