ADRB2 Gene Polymorphisms and Salbutamol Responsiveness in Serbian Children with Asthma
Apstrakt
Inhaled beta 2 adrenergic receptor (beta 2-AR) agonists are the mainstay of asthma therapy. The beta 2-AR protein is encoded by the ADRB2 gene and variants within this gene can have significant consequences for modulating the response to asthma therapy. This cross-sectional study performed at the University Children's Hospital in Belgrade, included 54 children with asthma. The subjects were genotyped for ADRB2 +46A gt G (Arg16Gly, rs1042713) and +79C gt G (G1n27G1u, rs1042714) polymorphisms and the association with asthma severity and response to inhaled salbutamol was examined. In Serbian asthmatic children, allele +46A was detected with a frequency of 41.7% and allele +79G was detected with a frequency of 23.1%. Allele +460 was found to be associated with a better response to inhaled salbutamol (p lt 0.05) and with mild form of asthma (p lt 0.05). Polymorphism ADRB2 +46A gt G may be a determinant of asthma severity and response to salbutamol in children with asthma. We did not find... any association of +79C gt G polymorphisms with the asthma severity and bronchodilator response to inhaled salbutamol. The results of this study can be potentially useful for personalization of asthma treatment.
Ključne reči:
Polymorphism / Bronchodilatator response / Asthma / ADRB2 geneIzvor:
Balkan Journal of Medical Genetics, 2018, 21, 1, 33-38Izdavač:
- Macedonian Acad Sciences Arts, Skopje
DOI: 10.2478/bjmg-2018-0007
ISSN: 1311-0160
WoS: 000448827400005
Scopus: 2-s2.0-85056127673
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Jovicić, N. AU - Babić, Tamara AU - Dragičević, Sandra AU - Nestorović, B. AU - Nikolić, Aleksandra PY - 2018 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1152 AB - Inhaled beta 2 adrenergic receptor (beta 2-AR) agonists are the mainstay of asthma therapy. The beta 2-AR protein is encoded by the ADRB2 gene and variants within this gene can have significant consequences for modulating the response to asthma therapy. This cross-sectional study performed at the University Children's Hospital in Belgrade, included 54 children with asthma. The subjects were genotyped for ADRB2 +46A gt G (Arg16Gly, rs1042713) and +79C gt G (G1n27G1u, rs1042714) polymorphisms and the association with asthma severity and response to inhaled salbutamol was examined. In Serbian asthmatic children, allele +46A was detected with a frequency of 41.7% and allele +79G was detected with a frequency of 23.1%. Allele +460 was found to be associated with a better response to inhaled salbutamol (p lt 0.05) and with mild form of asthma (p lt 0.05). Polymorphism ADRB2 +46A gt G may be a determinant of asthma severity and response to salbutamol in children with asthma. We did not find any association of +79C gt G polymorphisms with the asthma severity and bronchodilator response to inhaled salbutamol. The results of this study can be potentially useful for personalization of asthma treatment. PB - Macedonian Acad Sciences Arts, Skopje T2 - Balkan Journal of Medical Genetics T1 - ADRB2 Gene Polymorphisms and Salbutamol Responsiveness in Serbian Children with Asthma EP - 38 IS - 1 SP - 33 VL - 21 DO - 10.2478/bjmg-2018-0007 ER -
@article{ author = "Jovicić, N. and Babić, Tamara and Dragičević, Sandra and Nestorović, B. and Nikolić, Aleksandra", year = "2018", abstract = "Inhaled beta 2 adrenergic receptor (beta 2-AR) agonists are the mainstay of asthma therapy. The beta 2-AR protein is encoded by the ADRB2 gene and variants within this gene can have significant consequences for modulating the response to asthma therapy. This cross-sectional study performed at the University Children's Hospital in Belgrade, included 54 children with asthma. The subjects were genotyped for ADRB2 +46A gt G (Arg16Gly, rs1042713) and +79C gt G (G1n27G1u, rs1042714) polymorphisms and the association with asthma severity and response to inhaled salbutamol was examined. In Serbian asthmatic children, allele +46A was detected with a frequency of 41.7% and allele +79G was detected with a frequency of 23.1%. Allele +460 was found to be associated with a better response to inhaled salbutamol (p lt 0.05) and with mild form of asthma (p lt 0.05). Polymorphism ADRB2 +46A gt G may be a determinant of asthma severity and response to salbutamol in children with asthma. We did not find any association of +79C gt G polymorphisms with the asthma severity and bronchodilator response to inhaled salbutamol. The results of this study can be potentially useful for personalization of asthma treatment.", publisher = "Macedonian Acad Sciences Arts, Skopje", journal = "Balkan Journal of Medical Genetics", title = "ADRB2 Gene Polymorphisms and Salbutamol Responsiveness in Serbian Children with Asthma", pages = "38-33", number = "1", volume = "21", doi = "10.2478/bjmg-2018-0007" }
Jovicić, N., Babić, T., Dragičević, S., Nestorović, B.,& Nikolić, A.. (2018). ADRB2 Gene Polymorphisms and Salbutamol Responsiveness in Serbian Children with Asthma. in Balkan Journal of Medical Genetics Macedonian Acad Sciences Arts, Skopje., 21(1), 33-38. https://doi.org/10.2478/bjmg-2018-0007
Jovicić N, Babić T, Dragičević S, Nestorović B, Nikolić A. ADRB2 Gene Polymorphisms and Salbutamol Responsiveness in Serbian Children with Asthma. in Balkan Journal of Medical Genetics. 2018;21(1):33-38. doi:10.2478/bjmg-2018-0007 .
Jovicić, N., Babić, Tamara, Dragičević, Sandra, Nestorović, B., Nikolić, Aleksandra, "ADRB2 Gene Polymorphisms and Salbutamol Responsiveness in Serbian Children with Asthma" in Balkan Journal of Medical Genetics, 21, no. 1 (2018):33-38, https://doi.org/10.2478/bjmg-2018-0007 . .