Different coordination abilities of 1,7-and 4,7-phenanthroline in the reactions with copper(II) salts: Structural characterization and biological evaluation of the reaction products
Само за регистроване кориснике
2019
Аутори
Stevanović, Nevena Lj.Andrejević, Tina P.
Crochet, Aurelien
Ilić-Tomić, Tatjana
Drasković, Nenad S.
Nikodinović-Runić, Jasmina
Fromm, Katharina M.
Djuran, Milos
Glišić, Biljana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The reactions between equimolar amounts of CuX2 (X = NO3- and CF3SO3-) and two aromatic nitrogen-containing heterocycles differing in the position of nitrogen atoms, 1,7- and 4,7-phenanthroline (1,7-and 4,7-phen), were performed in ethanol/methanol at room temperature. When CuX 2 salts were mixed with 4,7-phen, two copper(II) complexes, [Cu(NO3)(2)(4,7-Hphen)(2)](NO3)(2) (1) and [Cu(CF3SO3)(4,7-phen)(2)(H2O)(2)]CF3SO3 (2), were formed. On the other hand, in the reaction of CuX2 salts with 1,7-phen, only 1,7-HphenNO(3) (3a/b) and 1,7-HphenCF(3)SO(3) (4) were obtained as the final products. The obtained products 1-4 were characterized by spectroscopic and X-ray diffraction techniques. In the copper(II) complexes 1 and 2, the coordination geometry around the Cu(II) ion is distorted octahedral and square pyramidal, respectively. The antimicrobial potential of the copper(II) complexes 1 and 2 and corresponding compounds used for their synthesis were assessed against four different bacterial... species and Candida albicans, displaying moderate growth inhibiting activity. The cytotoxic properties of the investigated complexes were also evaluated against the normal human lung fibroblast cell line (MRC-5) indicating moderate, yet more pronounced cytotoxicity than antimicrobial properties.
Кључне речи:
Structural characterization / Phenanthroline / Cytotoxicity / Copper(II) / Antimicrobial activityИзвор:
Polyhedron, 2019, 173Издавач:
- Pergamon-Elsevier Science Ltd, Oxford
Финансирање / пројекти:
- Swiss National Science Foundation through the SupraMedChem"Balkans.Net SCOPES Institutional Partnership [IZ74Z0_160515]
- Serbian Academy of Sciences and Arts [01-2019-F65, F128]
- FriMat (Fribourg Center for Nanomaterials)
- University of Fribourg, Switzerland
- Синтеза нових комплекса метала и испитивање њихових реакција са пептидима (RS-MESTD-Basic Research (BR or ON)-172036)
- Изучавање микробиолошког диверзитета и карактеризација корисних срединских микроорганизама (RS-MESTD-Basic Research (BR or ON)-173048)
DOI: 10.1016/j.poly.2019.114112
ISSN: 0277-5387
WoS: 000499768700009
Scopus: 2-s2.0-85071537520
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Stevanović, Nevena Lj. AU - Andrejević, Tina P. AU - Crochet, Aurelien AU - Ilić-Tomić, Tatjana AU - Drasković, Nenad S. AU - Nikodinović-Runić, Jasmina AU - Fromm, Katharina M. AU - Djuran, Milos AU - Glišić, Biljana PY - 2019 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1222 AB - The reactions between equimolar amounts of CuX2 (X = NO3- and CF3SO3-) and two aromatic nitrogen-containing heterocycles differing in the position of nitrogen atoms, 1,7- and 4,7-phenanthroline (1,7-and 4,7-phen), were performed in ethanol/methanol at room temperature. When CuX 2 salts were mixed with 4,7-phen, two copper(II) complexes, [Cu(NO3)(2)(4,7-Hphen)(2)](NO3)(2) (1) and [Cu(CF3SO3)(4,7-phen)(2)(H2O)(2)]CF3SO3 (2), were formed. On the other hand, in the reaction of CuX2 salts with 1,7-phen, only 1,7-HphenNO(3) (3a/b) and 1,7-HphenCF(3)SO(3) (4) were obtained as the final products. The obtained products 1-4 were characterized by spectroscopic and X-ray diffraction techniques. In the copper(II) complexes 1 and 2, the coordination geometry around the Cu(II) ion is distorted octahedral and square pyramidal, respectively. The antimicrobial potential of the copper(II) complexes 1 and 2 and corresponding compounds used for their synthesis were assessed against four different bacterial species and Candida albicans, displaying moderate growth inhibiting activity. The cytotoxic properties of the investigated complexes were also evaluated against the normal human lung fibroblast cell line (MRC-5) indicating moderate, yet more pronounced cytotoxicity than antimicrobial properties. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Polyhedron T1 - Different coordination abilities of 1,7-and 4,7-phenanthroline in the reactions with copper(II) salts: Structural characterization and biological evaluation of the reaction products VL - 173 DO - 10.1016/j.poly.2019.114112 ER -
@article{ author = "Stevanović, Nevena Lj. and Andrejević, Tina P. and Crochet, Aurelien and Ilić-Tomić, Tatjana and Drasković, Nenad S. and Nikodinović-Runić, Jasmina and Fromm, Katharina M. and Djuran, Milos and Glišić, Biljana", year = "2019", abstract = "The reactions between equimolar amounts of CuX2 (X = NO3- and CF3SO3-) and two aromatic nitrogen-containing heterocycles differing in the position of nitrogen atoms, 1,7- and 4,7-phenanthroline (1,7-and 4,7-phen), were performed in ethanol/methanol at room temperature. When CuX 2 salts were mixed with 4,7-phen, two copper(II) complexes, [Cu(NO3)(2)(4,7-Hphen)(2)](NO3)(2) (1) and [Cu(CF3SO3)(4,7-phen)(2)(H2O)(2)]CF3SO3 (2), were formed. On the other hand, in the reaction of CuX2 salts with 1,7-phen, only 1,7-HphenNO(3) (3a/b) and 1,7-HphenCF(3)SO(3) (4) were obtained as the final products. The obtained products 1-4 were characterized by spectroscopic and X-ray diffraction techniques. In the copper(II) complexes 1 and 2, the coordination geometry around the Cu(II) ion is distorted octahedral and square pyramidal, respectively. The antimicrobial potential of the copper(II) complexes 1 and 2 and corresponding compounds used for their synthesis were assessed against four different bacterial species and Candida albicans, displaying moderate growth inhibiting activity. The cytotoxic properties of the investigated complexes were also evaluated against the normal human lung fibroblast cell line (MRC-5) indicating moderate, yet more pronounced cytotoxicity than antimicrobial properties.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Polyhedron", title = "Different coordination abilities of 1,7-and 4,7-phenanthroline in the reactions with copper(II) salts: Structural characterization and biological evaluation of the reaction products", volume = "173", doi = "10.1016/j.poly.2019.114112" }
Stevanović, N. Lj., Andrejević, T. P., Crochet, A., Ilić-Tomić, T., Drasković, N. S., Nikodinović-Runić, J., Fromm, K. M., Djuran, M.,& Glišić, B.. (2019). Different coordination abilities of 1,7-and 4,7-phenanthroline in the reactions with copper(II) salts: Structural characterization and biological evaluation of the reaction products. in Polyhedron Pergamon-Elsevier Science Ltd, Oxford., 173. https://doi.org/10.1016/j.poly.2019.114112
Stevanović NL, Andrejević TP, Crochet A, Ilić-Tomić T, Drasković NS, Nikodinović-Runić J, Fromm KM, Djuran M, Glišić B. Different coordination abilities of 1,7-and 4,7-phenanthroline in the reactions with copper(II) salts: Structural characterization and biological evaluation of the reaction products. in Polyhedron. 2019;173. doi:10.1016/j.poly.2019.114112 .
Stevanović, Nevena Lj., Andrejević, Tina P., Crochet, Aurelien, Ilić-Tomić, Tatjana, Drasković, Nenad S., Nikodinović-Runić, Jasmina, Fromm, Katharina M., Djuran, Milos , Glišić, Biljana, "Different coordination abilities of 1,7-and 4,7-phenanthroline in the reactions with copper(II) salts: Structural characterization and biological evaluation of the reaction products" in Polyhedron, 173 (2019), https://doi.org/10.1016/j.poly.2019.114112 . .