IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury
Autori
Jordović, JelenaSimonović-Babić, Jasmina
Gašić, Vladimir
Kotur, Nikola
Zukić, Branka
Pavlović, Sonja
Lazarević, Ivana
Karalić, Danijela
Katanić, Nataša
Nikolić, Nataša
Urosević, Aleksandar
Nestorov, Jelena
Delić, Dragan
Bojović, Ksenija
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Introduction: Patients with severe fibrosis or cirrhosis are at high risk for liver-related complications, even after successful antiviral treatment and/or regression of fibrosis. These are the first published results concerning the role of IL-28B genotypes as predictors of the durability of sustained virological response (SVR) and long-term outcome, in patients with baseline severe fibrosis and cirrhosis caused by hepatitis C (HCV) infection. Methodology: Genetic testing for three different single nucleotide polymorphisms (SNP) near the IL28B gene, rs12979860, rs12980275 and rs8099917, was performed in 42 patients with HCV-related advanced fibrosis and cirrhosis, who achieved SVR after successful interferon-based treatment. Baseline clinical and laboratory parameters were analysed, as well as IL28B genotype association with late virological relapse, fibrosis progression and clinical outcomes. Results: The most prevalent genotypes in all three tested SNP positions were: CCrs12979860 ge...notype in 69% of patients, GT(rs)(8099917) in 78.6% and GG(rs)(12980275) in 47.6% of patients. The presence of IL28B CCrs12979860 genotype was identified as a negative predictor of late virological relapse. Further analysis did not confirm the association of other IL28B genotypes with the progression of fibrosis and clinical outcomes. Conclusions: Varying long-term prognosis in patients with HCV-related severe fibrosis and cirrhosis is due to multiple interactions between host genetic factors, virus and environment. These are first published results demonstrating the significance of IL28B CCrs12979860 genotype as a negative predictor of late virological relapse. A further investigation concerning genetic factors is necessary to identify patients under risk for late relapse, complications and unfavorable outcomes, so that they can be reevaluated and offered new treatment options.
Ključne reči:
outcome / late relapse / interleukine 28BIzvor:
Journal of Infection in Developing Countries, 2019, 13, 6, 526-535Izdavač:
- J Infection Developing Countries, Tramaniglio
DOI: 10.3855/jidc.11351
ISSN: 1972-2680
PubMed: 32058988
WoS: 000475711700009
Scopus: 2-s2.0-85069822706
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Jordović, Jelena AU - Simonović-Babić, Jasmina AU - Gašić, Vladimir AU - Kotur, Nikola AU - Zukić, Branka AU - Pavlović, Sonja AU - Lazarević, Ivana AU - Karalić, Danijela AU - Katanić, Nataša AU - Nikolić, Nataša AU - Urosević, Aleksandar AU - Nestorov, Jelena AU - Delić, Dragan AU - Bojović, Ksenija PY - 2019 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1247 AB - Introduction: Patients with severe fibrosis or cirrhosis are at high risk for liver-related complications, even after successful antiviral treatment and/or regression of fibrosis. These are the first published results concerning the role of IL-28B genotypes as predictors of the durability of sustained virological response (SVR) and long-term outcome, in patients with baseline severe fibrosis and cirrhosis caused by hepatitis C (HCV) infection. Methodology: Genetic testing for three different single nucleotide polymorphisms (SNP) near the IL28B gene, rs12979860, rs12980275 and rs8099917, was performed in 42 patients with HCV-related advanced fibrosis and cirrhosis, who achieved SVR after successful interferon-based treatment. Baseline clinical and laboratory parameters were analysed, as well as IL28B genotype association with late virological relapse, fibrosis progression and clinical outcomes. Results: The most prevalent genotypes in all three tested SNP positions were: CCrs12979860 genotype in 69% of patients, GT(rs)(8099917) in 78.6% and GG(rs)(12980275) in 47.6% of patients. The presence of IL28B CCrs12979860 genotype was identified as a negative predictor of late virological relapse. Further analysis did not confirm the association of other IL28B genotypes with the progression of fibrosis and clinical outcomes. Conclusions: Varying long-term prognosis in patients with HCV-related severe fibrosis and cirrhosis is due to multiple interactions between host genetic factors, virus and environment. These are first published results demonstrating the significance of IL28B CCrs12979860 genotype as a negative predictor of late virological relapse. A further investigation concerning genetic factors is necessary to identify patients under risk for late relapse, complications and unfavorable outcomes, so that they can be reevaluated and offered new treatment options. PB - J Infection Developing Countries, Tramaniglio T2 - Journal of Infection in Developing Countries T1 - IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury EP - 535 IS - 6 SP - 526 VL - 13 DO - 10.3855/jidc.11351 ER -
@article{ author = "Jordović, Jelena and Simonović-Babić, Jasmina and Gašić, Vladimir and Kotur, Nikola and Zukić, Branka and Pavlović, Sonja and Lazarević, Ivana and Karalić, Danijela and Katanić, Nataša and Nikolić, Nataša and Urosević, Aleksandar and Nestorov, Jelena and Delić, Dragan and Bojović, Ksenija", year = "2019", abstract = "Introduction: Patients with severe fibrosis or cirrhosis are at high risk for liver-related complications, even after successful antiviral treatment and/or regression of fibrosis. These are the first published results concerning the role of IL-28B genotypes as predictors of the durability of sustained virological response (SVR) and long-term outcome, in patients with baseline severe fibrosis and cirrhosis caused by hepatitis C (HCV) infection. Methodology: Genetic testing for three different single nucleotide polymorphisms (SNP) near the IL28B gene, rs12979860, rs12980275 and rs8099917, was performed in 42 patients with HCV-related advanced fibrosis and cirrhosis, who achieved SVR after successful interferon-based treatment. Baseline clinical and laboratory parameters were analysed, as well as IL28B genotype association with late virological relapse, fibrosis progression and clinical outcomes. Results: The most prevalent genotypes in all three tested SNP positions were: CCrs12979860 genotype in 69% of patients, GT(rs)(8099917) in 78.6% and GG(rs)(12980275) in 47.6% of patients. The presence of IL28B CCrs12979860 genotype was identified as a negative predictor of late virological relapse. Further analysis did not confirm the association of other IL28B genotypes with the progression of fibrosis and clinical outcomes. Conclusions: Varying long-term prognosis in patients with HCV-related severe fibrosis and cirrhosis is due to multiple interactions between host genetic factors, virus and environment. These are first published results demonstrating the significance of IL28B CCrs12979860 genotype as a negative predictor of late virological relapse. A further investigation concerning genetic factors is necessary to identify patients under risk for late relapse, complications and unfavorable outcomes, so that they can be reevaluated and offered new treatment options.", publisher = "J Infection Developing Countries, Tramaniglio", journal = "Journal of Infection in Developing Countries", title = "IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury", pages = "535-526", number = "6", volume = "13", doi = "10.3855/jidc.11351" }
Jordović, J., Simonović-Babić, J., Gašić, V., Kotur, N., Zukić, B., Pavlović, S., Lazarević, I., Karalić, D., Katanić, N., Nikolić, N., Urosević, A., Nestorov, J., Delić, D.,& Bojović, K.. (2019). IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury. in Journal of Infection in Developing Countries J Infection Developing Countries, Tramaniglio., 13(6), 526-535. https://doi.org/10.3855/jidc.11351
Jordović J, Simonović-Babić J, Gašić V, Kotur N, Zukić B, Pavlović S, Lazarević I, Karalić D, Katanić N, Nikolić N, Urosević A, Nestorov J, Delić D, Bojović K. IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury. in Journal of Infection in Developing Countries. 2019;13(6):526-535. doi:10.3855/jidc.11351 .
Jordović, Jelena, Simonović-Babić, Jasmina, Gašić, Vladimir, Kotur, Nikola, Zukić, Branka, Pavlović, Sonja, Lazarević, Ivana, Karalić, Danijela, Katanić, Nataša, Nikolić, Nataša, Urosević, Aleksandar, Nestorov, Jelena, Delić, Dragan, Bojović, Ksenija, "IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury" in Journal of Infection in Developing Countries, 13, no. 6 (2019):526-535, https://doi.org/10.3855/jidc.11351 . .