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IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury
dc.creator | Jordović, Jelena | |
dc.creator | Simonović-Babić, Jasmina | |
dc.creator | Gašić, Vladimir | |
dc.creator | Kotur, Nikola | |
dc.creator | Zukić, Branka | |
dc.creator | Pavlović, Sonja | |
dc.creator | Lazarević, Ivana | |
dc.creator | Karalić, Danijela | |
dc.creator | Katanić, Nataša | |
dc.creator | Nikolić, Nataša | |
dc.creator | Urosević, Aleksandar | |
dc.creator | Nestorov, Jelena | |
dc.creator | Delić, Dragan | |
dc.creator | Bojović, Ksenija | |
dc.date.accessioned | 2022-11-15T15:06:48Z | |
dc.date.available | 2022-11-15T15:06:48Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1972-2680 | |
dc.identifier.uri | https://imagine.imgge.bg.ac.rs/handle/123456789/1247 | |
dc.description.abstract | Introduction: Patients with severe fibrosis or cirrhosis are at high risk for liver-related complications, even after successful antiviral treatment and/or regression of fibrosis. These are the first published results concerning the role of IL-28B genotypes as predictors of the durability of sustained virological response (SVR) and long-term outcome, in patients with baseline severe fibrosis and cirrhosis caused by hepatitis C (HCV) infection. Methodology: Genetic testing for three different single nucleotide polymorphisms (SNP) near the IL28B gene, rs12979860, rs12980275 and rs8099917, was performed in 42 patients with HCV-related advanced fibrosis and cirrhosis, who achieved SVR after successful interferon-based treatment. Baseline clinical and laboratory parameters were analysed, as well as IL28B genotype association with late virological relapse, fibrosis progression and clinical outcomes. Results: The most prevalent genotypes in all three tested SNP positions were: CCrs12979860 genotype in 69% of patients, GT(rs)(8099917) in 78.6% and GG(rs)(12980275) in 47.6% of patients. The presence of IL28B CCrs12979860 genotype was identified as a negative predictor of late virological relapse. Further analysis did not confirm the association of other IL28B genotypes with the progression of fibrosis and clinical outcomes. Conclusions: Varying long-term prognosis in patients with HCV-related severe fibrosis and cirrhosis is due to multiple interactions between host genetic factors, virus and environment. These are first published results demonstrating the significance of IL28B CCrs12979860 genotype as a negative predictor of late virological relapse. A further investigation concerning genetic factors is necessary to identify patients under risk for late relapse, complications and unfavorable outcomes, so that they can be reevaluated and offered new treatment options. | en |
dc.publisher | J Infection Developing Countries, Tramaniglio | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Journal of Infection in Developing Countries | |
dc.subject | outcome | en |
dc.subject | late relapse | en |
dc.subject | interleukine 28B | en |
dc.title | IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury | en |
dc.type | article | |
dc.rights.license | BY | |
dc.citation.epage | 535 | |
dc.citation.issue | 6 | |
dc.citation.other | 13(6): 526-535 | |
dc.citation.rank | M23 | |
dc.citation.spage | 526 | |
dc.citation.volume | 13 | |
dc.identifier.doi | 10.3855/jidc.11351 | |
dc.identifier.fulltext | https://imagine.imgge.bg.ac.rs/bitstream/id/78667/IL_28B_genotypes_as_predictors_of_long_term_outcome_in_patients_with_hepatitis_C_related_severe_liver_injury_2019.pdf | |
dc.identifier.pmid | 32058988 | |
dc.identifier.scopus | 2-s2.0-85069822706 | |
dc.identifier.wos | 000475711700009 | |
dc.type.version | publishedVersion |