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Neuroprotective Role of Selected Antioxidant Agents in Preventing Cisplatin-Induced Damage of Human Neurons In Vitro
dc.creator | Popović, Jelena | |
dc.creator | Lazić, Andrijana | |
dc.creator | Paunesku, Tatjana | |
dc.creator | Ma, Qing | |
dc.creator | Chen, Si | |
dc.creator | Lai, Barry | |
dc.creator | Stevanović, Milena | |
dc.creator | Woloschak, Gayle E. | |
dc.date.accessioned | 2022-11-15T15:07:23Z | |
dc.date.available | 2022-11-15T15:07:23Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0272-4340 | |
dc.identifier.uri | https://imagine.imgge.bg.ac.rs/handle/123456789/1255 | |
dc.description.abstract | Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect of platinum-based chemotherapy and decreases the quality of life of cancer patients. We compared neuroprotective properties of several agents using an in vitro model of terminally differentiated human cells NT2-N derived from cell line NT2/D1. Sodium azide and an active metabolite of amifostine (WR1065) increase cell viability in simultaneous treatment with cisplatin. In addition, WR1065 protects the non-dividing neurons by decreasing cisplatin caused oxidative stress and apoptosis. Accumulation of Pt in cisplatin-treated cells was heterogeneous, but the frequency and concentration of Pt in cells were lowered in the presence of WR1065 as shown by X-ray fluorescence microscopy (XFM). Transition metals accumulation accompanied Pt increase in cells; this effect was equally diminished in the presence of WR1065. To analyze possible chemical modulation of Pt-DNA bonds, we examined the platinum L-III near edge spectrum by X-ray absorption spectroscopy. The spectrum found in cisplatin-DNA samples is altered differently by the addition of either WR1065 or sodium azide. Importantly, a similar change in Pt edge spectra was noted in cells treated with cisplatin and WR1065. Therefore, amifostine should be reconsidered as a candidate for treatments that reduce or prevent CIPN. | en |
dc.publisher | Springer/Plenum Publishers, New York | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173051/RS// | |
dc.relation | UICC Yamagiwa-Yoshida Memorial International Cancer Study Grant [YY2/2015/381414] | |
dc.relation | U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CH11357] | |
dc.relation | NIH ARRA Grant [SP0007167] | |
dc.relation | Northwestern University | |
dc.relation | E. I. DuPont de Nemours Co. | |
dc.relation | Dow Chemical Company | |
dc.relation | NCI CCSG [P30 CA060553] | |
dc.relation | NIH [1S10OD010398-01] | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Cellular and Molecular Neurobiology | |
dc.subject | XFM | en |
dc.subject | Neuroprotection | en |
dc.subject | Cisplatin | en |
dc.subject | CIPN | en |
dc.subject | Amifostine | en |
dc.title | Neuroprotective Role of Selected Antioxidant Agents in Preventing Cisplatin-Induced Damage of Human Neurons In Vitro | en |
dc.type | article | |
dc.rights.license | BY | |
dc.citation.epage | 636 | |
dc.citation.issue | 5 | |
dc.citation.other | 39(5): 619-636 | |
dc.citation.rank | M22 | |
dc.citation.spage | 619 | |
dc.citation.volume | 39 | |
dc.identifier.doi | 10.1007/s10571-019-00667-7 | |
dc.identifier.fulltext | https://imagine.imgge.bg.ac.rs/bitstream/id/2703/Neuroprotective_Role_of_Selected_Antioxidant_Agents_in_Preventing_2019.pdf | |
dc.identifier.pmid | 30874981 | |
dc.identifier.scopus | 2-s2.0-85062973382 | |
dc.identifier.wos | 000469033100005 | |
dc.type.version | publishedVersion |