Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata
Nema prikaza
Autori
Novaković, MiroslavBukvicki, Danka
Anđelković, Boban
Ilić-Tomić, Tatjana
Veljić, Milan
Tešević, Vele
Asakawa, Yoshinori
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Seven new bisbibenzyls (1-7) were isolated from the methanol extract of the liverwort Lunularia cruciata along with one previously known bibenzyl and five known bisbibenzyls. The structures of compounds 1-7 were elucidated on the basis of the spectroscopic data, These newly isolated bisbibenzyls may be divided into two groups, the acyclic bisbibenzyls, perrottetins (1-3), and the cyclic analogues, riccardins (4-7). Besides standard perrottetin and riccardin structures (1 and 4, respectively), they contain phenanthrene (3 and 5), dihydrophenanthrene (2), and quinone moieties (6 and 7), rarely found in natural products. The new compounds 3 and 5, as well as the known riccardin G, exhibited cytotoxic activity against the A549 lung cancer cell line with IC50 values of 5.0, 5.0, and 2.5 mu M, respectively.
Izvor:
Journal of Natural Products, 2019, 82, 4, 694-701Izdavač:
- Amer Chemical Soc, Washington
Finansiranje / projekti:
- Bioaktivni prirodni proizvodi samoniklih, gajenih i jestivih biljaka: određivanje struktura i aktivnosti (RS-MESTD-Basic Research (BR or ON)-172053)
- Mikromorfološka, fitohemijska i molekularna istraživanja biljaka - sistematski, ekološki i primenljivi aspekti (RS-MESTD-Basic Research (BR or ON)-173029)
- Izučavanje mikrobiološkog diverziteta i karakterizacija korisnih sredinskih mikroorganizama (RS-MESTD-Basic Research (BR or ON)-173048)
DOI: 10.1021/acs.jnatprod.8b00390
ISSN: 0163-3864
PubMed: 30848895
WoS: 000466442100002
Scopus: 2-s2.0-85062828630
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Novaković, Miroslav AU - Bukvicki, Danka AU - Anđelković, Boban AU - Ilić-Tomić, Tatjana AU - Veljić, Milan AU - Tešević, Vele AU - Asakawa, Yoshinori PY - 2019 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1281 AB - Seven new bisbibenzyls (1-7) were isolated from the methanol extract of the liverwort Lunularia cruciata along with one previously known bibenzyl and five known bisbibenzyls. The structures of compounds 1-7 were elucidated on the basis of the spectroscopic data, These newly isolated bisbibenzyls may be divided into two groups, the acyclic bisbibenzyls, perrottetins (1-3), and the cyclic analogues, riccardins (4-7). Besides standard perrottetin and riccardin structures (1 and 4, respectively), they contain phenanthrene (3 and 5), dihydrophenanthrene (2), and quinone moieties (6 and 7), rarely found in natural products. The new compounds 3 and 5, as well as the known riccardin G, exhibited cytotoxic activity against the A549 lung cancer cell line with IC50 values of 5.0, 5.0, and 2.5 mu M, respectively. PB - Amer Chemical Soc, Washington T2 - Journal of Natural Products T1 - Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata EP - 701 IS - 4 SP - 694 VL - 82 DO - 10.1021/acs.jnatprod.8b00390 ER -
@article{ author = "Novaković, Miroslav and Bukvicki, Danka and Anđelković, Boban and Ilić-Tomić, Tatjana and Veljić, Milan and Tešević, Vele and Asakawa, Yoshinori", year = "2019", abstract = "Seven new bisbibenzyls (1-7) were isolated from the methanol extract of the liverwort Lunularia cruciata along with one previously known bibenzyl and five known bisbibenzyls. The structures of compounds 1-7 were elucidated on the basis of the spectroscopic data, These newly isolated bisbibenzyls may be divided into two groups, the acyclic bisbibenzyls, perrottetins (1-3), and the cyclic analogues, riccardins (4-7). Besides standard perrottetin and riccardin structures (1 and 4, respectively), they contain phenanthrene (3 and 5), dihydrophenanthrene (2), and quinone moieties (6 and 7), rarely found in natural products. The new compounds 3 and 5, as well as the known riccardin G, exhibited cytotoxic activity against the A549 lung cancer cell line with IC50 values of 5.0, 5.0, and 2.5 mu M, respectively.", publisher = "Amer Chemical Soc, Washington", journal = "Journal of Natural Products", title = "Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata", pages = "701-694", number = "4", volume = "82", doi = "10.1021/acs.jnatprod.8b00390" }
Novaković, M., Bukvicki, D., Anđelković, B., Ilić-Tomić, T., Veljić, M., Tešević, V.,& Asakawa, Y.. (2019). Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata. in Journal of Natural Products Amer Chemical Soc, Washington., 82(4), 694-701. https://doi.org/10.1021/acs.jnatprod.8b00390
Novaković M, Bukvicki D, Anđelković B, Ilić-Tomić T, Veljić M, Tešević V, Asakawa Y. Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata. in Journal of Natural Products. 2019;82(4):694-701. doi:10.1021/acs.jnatprod.8b00390 .
Novaković, Miroslav, Bukvicki, Danka, Anđelković, Boban, Ilić-Tomić, Tatjana, Veljić, Milan, Tešević, Vele, Asakawa, Yoshinori, "Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata" in Journal of Natural Products, 82, no. 4 (2019):694-701, https://doi.org/10.1021/acs.jnatprod.8b00390 . .