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Synthesis and initial biological evaluation of myxocoumarin B
dc.creator | Mueller, Jonas I. | |
dc.creator | Kusserow, Kalina | |
dc.creator | Hertrampf, Gesa | |
dc.creator | Pavić, Aleksandar | |
dc.creator | Nikodinović-Runić, Jasmina | |
dc.creator | Gulder, Tobias A. M. | |
dc.date.accessioned | 2022-11-15T15:10:00Z | |
dc.date.available | 2022-11-15T15:10:00Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1477-0520 | |
dc.identifier.uri | https://imagine.imgge.bg.ac.rs/handle/123456789/1290 | |
dc.description.abstract | The myxocoumarins A and B from Stigmatella aurantiaca MYX-030 are natural products featuring unusual nitro-and long-chain alkyl substitution. While myxocoumarin A was shown to exhibit strong antifungal properties, the antifungal potential of myxocoumarin B was not yet assessed due to low production titers during initial isolation. We therefore developed a total synthesis of myxocoumarin B that involves a late-stage Pd-catalyzed nitration of the coumarin core. The availability of synthetic material facilitated the initial evaluation of the bioactivity of myxocoumarin B, which revealed a lack of activity against medically relevant Candida sp. and low cytotoxicity in vitro against human fibroblasts (MRC-5) and in vivo (zebrafish). | en |
dc.publisher | Royal Soc Chemistry, Cambridge | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173048/RS// | |
dc.relation | DAAD (Deutscher Akademischer Austauschdienst) | |
dc.relation | DFG [GU 1233/11] | |
dc.relation | DFG (Center for Integrated Protein Science Munich CIPSM) | |
dc.rights | restrictedAccess | |
dc.source | Organic & Biomolecular Chemistry | |
dc.title | Synthesis and initial biological evaluation of myxocoumarin B | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 1969 | |
dc.citation.issue | 7 | |
dc.citation.other | 17(7): 1966-1969 | |
dc.citation.rank | M21 | |
dc.citation.spage | 1966 | |
dc.citation.volume | 17 | |
dc.identifier.doi | 10.1039/c8ob02273a | |
dc.identifier.pmid | 30357251 | |
dc.identifier.scopus | 2-s2.0-85061515800 | |
dc.identifier.wos | 000458679200055 | |
dc.type.version | publishedVersion |
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