Controlled drug release carriers based on PCL/PEO/PCL block copolymers
Само за регистроване кориснике
2019
Аутори
Ponjavić, MarijanaNikolić, Marija S.
Nikodinović-Runić, Jasmina
Ilić-Tomić, Tatjana
Đonlagić, J.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In order to create a new drug delivery system, the ibuprofen-loaded triblock copolymer PCL/PEO/PCL (PCEC) microspheres with a low PEO content ( lt 2 wt%) were prepared by oil in water (o/w) solvent evaporation technique. The influence of PEO content, molecular weight of a polymer matrix and drug loading on the ibuprofen release profiles were evaluated. The interactions between polymer matrix and ibuprofen were detected by FTIR analysis. The presence of hydrophilic PEO segment in PCL chains caused the decrease in particle size, which further had a great impact on the drug release kinetics, i.e., initially faster release and significantly higher quantity of released drug compared to neat PCL. Ibuprofen release behavior from polymer matrix was governed by a diffusion process. In vitro cytotoxicity tests revealed that empty PCL and PCEC microspheres were not toxic at low concentrations, while ibuprofen-loaded microspheres exhibited cytotoxicity correlated with amounts of incorporated drug.
Кључне речи:
triblock copolymers / PCL / microspheres / ibuprofen / drug delivery / CytotoxicityИзвор:
International Journal of Polymeric Materials and Polymeric Biomaterials, 2019, 68, 6, 308-318Издавач:
- Taylor & Francis As, Oslo
Финансирање / пројекти:
- Синтеза и карактеризација нових функционалних полимера и полимерних нанокомпозита (RS-MESTD-Basic Research (BR or ON)-172062)
- Изучавање микробиолошког диверзитета и карактеризација корисних срединских микроорганизама (RS-MESTD-Basic Research (BR or ON)-173048)
DOI: 10.1080/00914037.2018.1445631
ISSN: 0091-4037
WoS: 000462974900003
Scopus: 2-s2.0-85044959256
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Ponjavić, Marijana AU - Nikolić, Marija S. AU - Nikodinović-Runić, Jasmina AU - Ilić-Tomić, Tatjana AU - Đonlagić, J. PY - 2019 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1294 AB - In order to create a new drug delivery system, the ibuprofen-loaded triblock copolymer PCL/PEO/PCL (PCEC) microspheres with a low PEO content ( lt 2 wt%) were prepared by oil in water (o/w) solvent evaporation technique. The influence of PEO content, molecular weight of a polymer matrix and drug loading on the ibuprofen release profiles were evaluated. The interactions between polymer matrix and ibuprofen were detected by FTIR analysis. The presence of hydrophilic PEO segment in PCL chains caused the decrease in particle size, which further had a great impact on the drug release kinetics, i.e., initially faster release and significantly higher quantity of released drug compared to neat PCL. Ibuprofen release behavior from polymer matrix was governed by a diffusion process. In vitro cytotoxicity tests revealed that empty PCL and PCEC microspheres were not toxic at low concentrations, while ibuprofen-loaded microspheres exhibited cytotoxicity correlated with amounts of incorporated drug. PB - Taylor & Francis As, Oslo T2 - International Journal of Polymeric Materials and Polymeric Biomaterials T1 - Controlled drug release carriers based on PCL/PEO/PCL block copolymers EP - 318 IS - 6 SP - 308 VL - 68 DO - 10.1080/00914037.2018.1445631 ER -
@article{ author = "Ponjavić, Marijana and Nikolić, Marija S. and Nikodinović-Runić, Jasmina and Ilić-Tomić, Tatjana and Đonlagić, J.", year = "2019", abstract = "In order to create a new drug delivery system, the ibuprofen-loaded triblock copolymer PCL/PEO/PCL (PCEC) microspheres with a low PEO content ( lt 2 wt%) were prepared by oil in water (o/w) solvent evaporation technique. The influence of PEO content, molecular weight of a polymer matrix and drug loading on the ibuprofen release profiles were evaluated. The interactions between polymer matrix and ibuprofen were detected by FTIR analysis. The presence of hydrophilic PEO segment in PCL chains caused the decrease in particle size, which further had a great impact on the drug release kinetics, i.e., initially faster release and significantly higher quantity of released drug compared to neat PCL. Ibuprofen release behavior from polymer matrix was governed by a diffusion process. In vitro cytotoxicity tests revealed that empty PCL and PCEC microspheres were not toxic at low concentrations, while ibuprofen-loaded microspheres exhibited cytotoxicity correlated with amounts of incorporated drug.", publisher = "Taylor & Francis As, Oslo", journal = "International Journal of Polymeric Materials and Polymeric Biomaterials", title = "Controlled drug release carriers based on PCL/PEO/PCL block copolymers", pages = "318-308", number = "6", volume = "68", doi = "10.1080/00914037.2018.1445631" }
Ponjavić, M., Nikolić, M. S., Nikodinović-Runić, J., Ilić-Tomić, T.,& Đonlagić, J.. (2019). Controlled drug release carriers based on PCL/PEO/PCL block copolymers. in International Journal of Polymeric Materials and Polymeric Biomaterials Taylor & Francis As, Oslo., 68(6), 308-318. https://doi.org/10.1080/00914037.2018.1445631
Ponjavić M, Nikolić MS, Nikodinović-Runić J, Ilić-Tomić T, Đonlagić J. Controlled drug release carriers based on PCL/PEO/PCL block copolymers. in International Journal of Polymeric Materials and Polymeric Biomaterials. 2019;68(6):308-318. doi:10.1080/00914037.2018.1445631 .
Ponjavić, Marijana, Nikolić, Marija S., Nikodinović-Runić, Jasmina, Ilić-Tomić, Tatjana, Đonlagić, J., "Controlled drug release carriers based on PCL/PEO/PCL block copolymers" in International Journal of Polymeric Materials and Polymeric Biomaterials, 68, no. 6 (2019):308-318, https://doi.org/10.1080/00914037.2018.1445631 . .