Zinc(II) complexes with aromatic nitrogen-containing heterocycles as antifungal agents: Synergistic activity with clinically used drug nystatin
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Authors
Andrejević, Tina P.Warzajtis, Beata
Glišić, Biljana
Vojnović, Sandra
Mojicević, Marija
Stevanović, Nevena Lj.
Nikodinović-Runić, Jasmina
Rychlewska, Urszula
Djuran, Milos
Article (Published version)
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Three novel Zn(II) complexes, [ZnCl2(qz)(2)] (1), [ZnCl2(1,5-naph)](n) (2) and [ZnCl2(4,7-phen)(2)] (3), where qz is quinazoline, 1,5-naph is 1,5-naphthyridine and 4,7-phen is 4,7-phenanthroline, were synthesized by the reactions of ZnCl2 and the corresponding N-heterocyclic ligand in 1:2 molar ratio in ethanol at ambient temperature. The characterization of these complexes was done by NMR, IR and UV-Vis spectroscopy, and their crystal structures were determined by single-crystal X-ray diffraction analysis. Complexes 1 and 3 are mononuclear species, in which Zn(II) ion is tetrahedrally coordinated by two nitrogen atoms belonging to two qz or 4,7-phen ligands, respectively, and by two chloride anions, while complex 2 is a 1D coordination polymer that contains 1,5-naph as bridging ligand between two metal ions. In agar disc-diffusion assay, complexes 1-3 manifested good inhibitory activity against two investigated Candida strains (C. albicans and C. parapsilosis), while not inducing toxi...c effects on the healthy human fibroblast cell line (MRC-5). This activity was not fungicidal, as revealed by the broth microdilution assay, however complex 3 showed the ability to modulate Candida hyphae formation, which is an important process during infection and showed significant synergistic effect with clinically used antifungal polyene nystatin.
Keywords:
Zinc(II) complexes / Synergy / N-heterocycles / Filamentation inhibition / Cytotoxicity / Anti-Candida activitySource:
Journal of Inorganic Biochemistry, 2020, 208Publisher:
- Elsevier Science Inc, New York
Funding / projects:
- Serbian Academy of Sciences and Arts [01-2019-F65, F128]
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200042 (University of Belgrade, Institute of Molecular Genetics and Genetic Engineering) (RS-MESTD-inst-2020-200042)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200122 (University of Kragujevac, Faculty of Science) (RS-MESTD-inst-2020-200122)
DOI: 10.1016/j.jinorgbio.2020.111089
ISSN: 0162-0134
PubMed: 32442762
WoS: 000541732000018
Scopus: 2-s2.0-85084855564
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Andrejević, Tina P. AU - Warzajtis, Beata AU - Glišić, Biljana AU - Vojnović, Sandra AU - Mojicević, Marija AU - Stevanović, Nevena Lj. AU - Nikodinović-Runić, Jasmina AU - Rychlewska, Urszula AU - Djuran, Milos PY - 2020 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1325 AB - Three novel Zn(II) complexes, [ZnCl2(qz)(2)] (1), [ZnCl2(1,5-naph)](n) (2) and [ZnCl2(4,7-phen)(2)] (3), where qz is quinazoline, 1,5-naph is 1,5-naphthyridine and 4,7-phen is 4,7-phenanthroline, were synthesized by the reactions of ZnCl2 and the corresponding N-heterocyclic ligand in 1:2 molar ratio in ethanol at ambient temperature. The characterization of these complexes was done by NMR, IR and UV-Vis spectroscopy, and their crystal structures were determined by single-crystal X-ray diffraction analysis. Complexes 1 and 3 are mononuclear species, in which Zn(II) ion is tetrahedrally coordinated by two nitrogen atoms belonging to two qz or 4,7-phen ligands, respectively, and by two chloride anions, while complex 2 is a 1D coordination polymer that contains 1,5-naph as bridging ligand between two metal ions. In agar disc-diffusion assay, complexes 1-3 manifested good inhibitory activity against two investigated Candida strains (C. albicans and C. parapsilosis), while not inducing toxic effects on the healthy human fibroblast cell line (MRC-5). This activity was not fungicidal, as revealed by the broth microdilution assay, however complex 3 showed the ability to modulate Candida hyphae formation, which is an important process during infection and showed significant synergistic effect with clinically used antifungal polyene nystatin. PB - Elsevier Science Inc, New York T2 - Journal of Inorganic Biochemistry T1 - Zinc(II) complexes with aromatic nitrogen-containing heterocycles as antifungal agents: Synergistic activity with clinically used drug nystatin VL - 208 DO - 10.1016/j.jinorgbio.2020.111089 ER -
@article{ author = "Andrejević, Tina P. and Warzajtis, Beata and Glišić, Biljana and Vojnović, Sandra and Mojicević, Marija and Stevanović, Nevena Lj. and Nikodinović-Runić, Jasmina and Rychlewska, Urszula and Djuran, Milos", year = "2020", abstract = "Three novel Zn(II) complexes, [ZnCl2(qz)(2)] (1), [ZnCl2(1,5-naph)](n) (2) and [ZnCl2(4,7-phen)(2)] (3), where qz is quinazoline, 1,5-naph is 1,5-naphthyridine and 4,7-phen is 4,7-phenanthroline, were synthesized by the reactions of ZnCl2 and the corresponding N-heterocyclic ligand in 1:2 molar ratio in ethanol at ambient temperature. The characterization of these complexes was done by NMR, IR and UV-Vis spectroscopy, and their crystal structures were determined by single-crystal X-ray diffraction analysis. Complexes 1 and 3 are mononuclear species, in which Zn(II) ion is tetrahedrally coordinated by two nitrogen atoms belonging to two qz or 4,7-phen ligands, respectively, and by two chloride anions, while complex 2 is a 1D coordination polymer that contains 1,5-naph as bridging ligand between two metal ions. In agar disc-diffusion assay, complexes 1-3 manifested good inhibitory activity against two investigated Candida strains (C. albicans and C. parapsilosis), while not inducing toxic effects on the healthy human fibroblast cell line (MRC-5). This activity was not fungicidal, as revealed by the broth microdilution assay, however complex 3 showed the ability to modulate Candida hyphae formation, which is an important process during infection and showed significant synergistic effect with clinically used antifungal polyene nystatin.", publisher = "Elsevier Science Inc, New York", journal = "Journal of Inorganic Biochemistry", title = "Zinc(II) complexes with aromatic nitrogen-containing heterocycles as antifungal agents: Synergistic activity with clinically used drug nystatin", volume = "208", doi = "10.1016/j.jinorgbio.2020.111089" }
Andrejević, T. P., Warzajtis, B., Glišić, B., Vojnović, S., Mojicević, M., Stevanović, N. Lj., Nikodinović-Runić, J., Rychlewska, U.,& Djuran, M.. (2020). Zinc(II) complexes with aromatic nitrogen-containing heterocycles as antifungal agents: Synergistic activity with clinically used drug nystatin. in Journal of Inorganic Biochemistry Elsevier Science Inc, New York., 208. https://doi.org/10.1016/j.jinorgbio.2020.111089
Andrejević TP, Warzajtis B, Glišić B, Vojnović S, Mojicević M, Stevanović NL, Nikodinović-Runić J, Rychlewska U, Djuran M. Zinc(II) complexes with aromatic nitrogen-containing heterocycles as antifungal agents: Synergistic activity with clinically used drug nystatin. in Journal of Inorganic Biochemistry. 2020;208. doi:10.1016/j.jinorgbio.2020.111089 .
Andrejević, Tina P., Warzajtis, Beata, Glišić, Biljana, Vojnović, Sandra, Mojicević, Marija, Stevanović, Nevena Lj., Nikodinović-Runić, Jasmina, Rychlewska, Urszula, Djuran, Milos, "Zinc(II) complexes with aromatic nitrogen-containing heterocycles as antifungal agents: Synergistic activity with clinically used drug nystatin" in Journal of Inorganic Biochemistry, 208 (2020), https://doi.org/10.1016/j.jinorgbio.2020.111089 . .