Zinc(II) complexes with aromatic nitrogen-containing heterocycles as antifungal agents: Synergistic activity with clinically used drug nystatin
Нема приказа
Аутори
Andrejević, Tina P.![](/themes/Mirageimagine/images/orcid.png)
Warzajtis, Beata
Glišić, Biljana
![](/themes/Mirageimagine/images/orcid.png)
Vojnović, Sandra
![](/themes/Mirageimagine/images/orcid.png)
Mojicević, Marija
![](/themes/Mirageimagine/images/orcid.png)
Stevanović, Nevena Lj.
![](/themes/Mirageimagine/images/orcid.png)
Nikodinović-Runić, Jasmina
![](/themes/Mirageimagine/images/orcid.png)
Rychlewska, Urszula
Djuran, Milos
Чланак у часопису (Објављена верзија)
![](/themes/Mirageimagine//images/creativecommons/arr.png)
Метаподаци
Приказ свих података о документуАпстракт
Three novel Zn(II) complexes, [ZnCl2(qz)(2)] (1), [ZnCl2(1,5-naph)](n) (2) and [ZnCl2(4,7-phen)(2)] (3), where qz is quinazoline, 1,5-naph is 1,5-naphthyridine and 4,7-phen is 4,7-phenanthroline, were synthesized by the reactions of ZnCl2 and the corresponding N-heterocyclic ligand in 1:2 molar ratio in ethanol at ambient temperature. The characterization of these complexes was done by NMR, IR and UV-Vis spectroscopy, and their crystal structures were determined by single-crystal X-ray diffraction analysis. Complexes 1 and 3 are mononuclear species, in which Zn(II) ion is tetrahedrally coordinated by two nitrogen atoms belonging to two qz or 4,7-phen ligands, respectively, and by two chloride anions, while complex 2 is a 1D coordination polymer that contains 1,5-naph as bridging ligand between two metal ions. In agar disc-diffusion assay, complexes 1-3 manifested good inhibitory activity against two investigated Candida strains (C. albicans and C. parapsilosis), while not inducing toxi...c effects on the healthy human fibroblast cell line (MRC-5). This activity was not fungicidal, as revealed by the broth microdilution assay, however complex 3 showed the ability to modulate Candida hyphae formation, which is an important process during infection and showed significant synergistic effect with clinically used antifungal polyene nystatin.
Кључне речи:
Zinc(II) complexes / Synergy / N-heterocycles / Filamentation inhibition / Cytotoxicity / Anti-Candida activityИзвор:
Journal of Inorganic Biochemistry, 2020, 208Издавач:
- Elsevier Science Inc, New York
Финансирање / пројекти:
- Serbian Academy of Sciences and Arts [01-2019-F65, F128]
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200042 (Универзитет у Београду, Институт за молекуларну генетику и генетичко инжењерство) (RS-MESTD-inst-2020-200042)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200122 (Универзитет у Крагујевцу, Природно-математички факултет) (RS-MESTD-inst-2020-200122)
DOI: 10.1016/j.jinorgbio.2020.111089
ISSN: 0162-0134
PubMed: 32442762
WoS: 000541732000018
Scopus: 2-s2.0-85084855564
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Andrejević, Tina P. AU - Warzajtis, Beata AU - Glišić, Biljana AU - Vojnović, Sandra AU - Mojicević, Marija AU - Stevanović, Nevena Lj. AU - Nikodinović-Runić, Jasmina AU - Rychlewska, Urszula AU - Djuran, Milos PY - 2020 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1325 AB - Three novel Zn(II) complexes, [ZnCl2(qz)(2)] (1), [ZnCl2(1,5-naph)](n) (2) and [ZnCl2(4,7-phen)(2)] (3), where qz is quinazoline, 1,5-naph is 1,5-naphthyridine and 4,7-phen is 4,7-phenanthroline, were synthesized by the reactions of ZnCl2 and the corresponding N-heterocyclic ligand in 1:2 molar ratio in ethanol at ambient temperature. The characterization of these complexes was done by NMR, IR and UV-Vis spectroscopy, and their crystal structures were determined by single-crystal X-ray diffraction analysis. Complexes 1 and 3 are mononuclear species, in which Zn(II) ion is tetrahedrally coordinated by two nitrogen atoms belonging to two qz or 4,7-phen ligands, respectively, and by two chloride anions, while complex 2 is a 1D coordination polymer that contains 1,5-naph as bridging ligand between two metal ions. In agar disc-diffusion assay, complexes 1-3 manifested good inhibitory activity against two investigated Candida strains (C. albicans and C. parapsilosis), while not inducing toxic effects on the healthy human fibroblast cell line (MRC-5). This activity was not fungicidal, as revealed by the broth microdilution assay, however complex 3 showed the ability to modulate Candida hyphae formation, which is an important process during infection and showed significant synergistic effect with clinically used antifungal polyene nystatin. PB - Elsevier Science Inc, New York T2 - Journal of Inorganic Biochemistry T1 - Zinc(II) complexes with aromatic nitrogen-containing heterocycles as antifungal agents: Synergistic activity with clinically used drug nystatin VL - 208 DO - 10.1016/j.jinorgbio.2020.111089 ER -
@article{ author = "Andrejević, Tina P. and Warzajtis, Beata and Glišić, Biljana and Vojnović, Sandra and Mojicević, Marija and Stevanović, Nevena Lj. and Nikodinović-Runić, Jasmina and Rychlewska, Urszula and Djuran, Milos", year = "2020", abstract = "Three novel Zn(II) complexes, [ZnCl2(qz)(2)] (1), [ZnCl2(1,5-naph)](n) (2) and [ZnCl2(4,7-phen)(2)] (3), where qz is quinazoline, 1,5-naph is 1,5-naphthyridine and 4,7-phen is 4,7-phenanthroline, were synthesized by the reactions of ZnCl2 and the corresponding N-heterocyclic ligand in 1:2 molar ratio in ethanol at ambient temperature. The characterization of these complexes was done by NMR, IR and UV-Vis spectroscopy, and their crystal structures were determined by single-crystal X-ray diffraction analysis. Complexes 1 and 3 are mononuclear species, in which Zn(II) ion is tetrahedrally coordinated by two nitrogen atoms belonging to two qz or 4,7-phen ligands, respectively, and by two chloride anions, while complex 2 is a 1D coordination polymer that contains 1,5-naph as bridging ligand between two metal ions. In agar disc-diffusion assay, complexes 1-3 manifested good inhibitory activity against two investigated Candida strains (C. albicans and C. parapsilosis), while not inducing toxic effects on the healthy human fibroblast cell line (MRC-5). This activity was not fungicidal, as revealed by the broth microdilution assay, however complex 3 showed the ability to modulate Candida hyphae formation, which is an important process during infection and showed significant synergistic effect with clinically used antifungal polyene nystatin.", publisher = "Elsevier Science Inc, New York", journal = "Journal of Inorganic Biochemistry", title = "Zinc(II) complexes with aromatic nitrogen-containing heterocycles as antifungal agents: Synergistic activity with clinically used drug nystatin", volume = "208", doi = "10.1016/j.jinorgbio.2020.111089" }
Andrejević, T. P., Warzajtis, B., Glišić, B., Vojnović, S., Mojicević, M., Stevanović, N. Lj., Nikodinović-Runić, J., Rychlewska, U.,& Djuran, M.. (2020). Zinc(II) complexes with aromatic nitrogen-containing heterocycles as antifungal agents: Synergistic activity with clinically used drug nystatin. in Journal of Inorganic Biochemistry Elsevier Science Inc, New York., 208. https://doi.org/10.1016/j.jinorgbio.2020.111089
Andrejević TP, Warzajtis B, Glišić B, Vojnović S, Mojicević M, Stevanović NL, Nikodinović-Runić J, Rychlewska U, Djuran M. Zinc(II) complexes with aromatic nitrogen-containing heterocycles as antifungal agents: Synergistic activity with clinically used drug nystatin. in Journal of Inorganic Biochemistry. 2020;208. doi:10.1016/j.jinorgbio.2020.111089 .
Andrejević, Tina P., Warzajtis, Beata, Glišić, Biljana, Vojnović, Sandra, Mojicević, Marija, Stevanović, Nevena Lj., Nikodinović-Runić, Jasmina, Rychlewska, Urszula, Djuran, Milos, "Zinc(II) complexes with aromatic nitrogen-containing heterocycles as antifungal agents: Synergistic activity with clinically used drug nystatin" in Journal of Inorganic Biochemistry, 208 (2020), https://doi.org/10.1016/j.jinorgbio.2020.111089 . .