Controlled Curcumin Release from Hydrogel Scaffold Platform Based on 2-Hydroxyethyl Methacrylate/Gelatin/Alginate/Iron(III) Oxide
Нема приказа
Аутори
Babić, Marija M.Vukomanović, Marija
Stefanić, Martin
Nikodinović-Runić, Jasmina
Tomić, Simonida Lj.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The strategy of combining polymers of natural and synthetic origin with inorganic components to use their unique synergistic effect for the development of the novel, sophisticated, and efficient 3D polymeric biomaterials, whose structure and properties mimic the extracellular matrix and simultaneously represent the suitable hydrogel platform for controlled drug release, is presented. The novel versatile 2-hydroxyethyl methacrylate/gelatin/alginate/iron(III) oxide based hydrogels are prepared by a simple but effective method-modified porogenation. Chemical composition, morphology, swelling capacity, porosity, mechanical properties, effects on cell viability, and in vitro degradation are tested to correlate the material's composition with the corresponding properties. The hydrogels show an interconnected porous microstructure, satisfactory mechanical strength, pH-sensitivity, and favorable curcumin release performances. The materials show good compatibility with healthy human fibroblast ...in cell culture judged by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, suggesting newly synthesized hydrogels as potentially a new generation of 3D biomaterials with tunable properties for versatile biomedical and pharmaceutical applications.
Кључне речи:
scaffolding biomaterials / iron(III) oxide based hydrogels / gelatin / degradable scaffolds / controlled curcumin release / alginate / 2-hydroxyethyl methacrylateИзвор:
Macromolecular Chemistry and Physics, 2020, 221, 20Издавач:
- Wiley-V C H Verlag Gmbh, Weinheim
Финансирање / пројекти:
- SCOPES program of the Swiss National Science Foundation (SNSF)
- Swiss Agency for Development and Cooperation (SDC) [IZ73ZO_152327]
- Синтеза и карактеризација нових функционалних полимера и полимерних нанокомпозита (RS-MESTD-Basic Research (BR or ON)-172062)
- Хемијско и структурно дизајнирање наноматеријала за примену у медицини и инжењерству ткива (RS-MESTD-Basic Research (BR or ON)-172026)
DOI: 10.1002/macp.202000186
ISSN: 1022-1352
WoS: 000572182800001
Scopus: 2-s2.0-85091348146
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Babić, Marija M. AU - Vukomanović, Marija AU - Stefanić, Martin AU - Nikodinović-Runić, Jasmina AU - Tomić, Simonida Lj. PY - 2020 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1356 AB - The strategy of combining polymers of natural and synthetic origin with inorganic components to use their unique synergistic effect for the development of the novel, sophisticated, and efficient 3D polymeric biomaterials, whose structure and properties mimic the extracellular matrix and simultaneously represent the suitable hydrogel platform for controlled drug release, is presented. The novel versatile 2-hydroxyethyl methacrylate/gelatin/alginate/iron(III) oxide based hydrogels are prepared by a simple but effective method-modified porogenation. Chemical composition, morphology, swelling capacity, porosity, mechanical properties, effects on cell viability, and in vitro degradation are tested to correlate the material's composition with the corresponding properties. The hydrogels show an interconnected porous microstructure, satisfactory mechanical strength, pH-sensitivity, and favorable curcumin release performances. The materials show good compatibility with healthy human fibroblast in cell culture judged by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, suggesting newly synthesized hydrogels as potentially a new generation of 3D biomaterials with tunable properties for versatile biomedical and pharmaceutical applications. PB - Wiley-V C H Verlag Gmbh, Weinheim T2 - Macromolecular Chemistry and Physics T1 - Controlled Curcumin Release from Hydrogel Scaffold Platform Based on 2-Hydroxyethyl Methacrylate/Gelatin/Alginate/Iron(III) Oxide IS - 20 VL - 221 DO - 10.1002/macp.202000186 ER -
@article{ author = "Babić, Marija M. and Vukomanović, Marija and Stefanić, Martin and Nikodinović-Runić, Jasmina and Tomić, Simonida Lj.", year = "2020", abstract = "The strategy of combining polymers of natural and synthetic origin with inorganic components to use their unique synergistic effect for the development of the novel, sophisticated, and efficient 3D polymeric biomaterials, whose structure and properties mimic the extracellular matrix and simultaneously represent the suitable hydrogel platform for controlled drug release, is presented. The novel versatile 2-hydroxyethyl methacrylate/gelatin/alginate/iron(III) oxide based hydrogels are prepared by a simple but effective method-modified porogenation. Chemical composition, morphology, swelling capacity, porosity, mechanical properties, effects on cell viability, and in vitro degradation are tested to correlate the material's composition with the corresponding properties. The hydrogels show an interconnected porous microstructure, satisfactory mechanical strength, pH-sensitivity, and favorable curcumin release performances. The materials show good compatibility with healthy human fibroblast in cell culture judged by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, suggesting newly synthesized hydrogels as potentially a new generation of 3D biomaterials with tunable properties for versatile biomedical and pharmaceutical applications.", publisher = "Wiley-V C H Verlag Gmbh, Weinheim", journal = "Macromolecular Chemistry and Physics", title = "Controlled Curcumin Release from Hydrogel Scaffold Platform Based on 2-Hydroxyethyl Methacrylate/Gelatin/Alginate/Iron(III) Oxide", number = "20", volume = "221", doi = "10.1002/macp.202000186" }
Babić, M. M., Vukomanović, M., Stefanić, M., Nikodinović-Runić, J.,& Tomić, S. Lj.. (2020). Controlled Curcumin Release from Hydrogel Scaffold Platform Based on 2-Hydroxyethyl Methacrylate/Gelatin/Alginate/Iron(III) Oxide. in Macromolecular Chemistry and Physics Wiley-V C H Verlag Gmbh, Weinheim., 221(20). https://doi.org/10.1002/macp.202000186
Babić MM, Vukomanović M, Stefanić M, Nikodinović-Runić J, Tomić SL. Controlled Curcumin Release from Hydrogel Scaffold Platform Based on 2-Hydroxyethyl Methacrylate/Gelatin/Alginate/Iron(III) Oxide. in Macromolecular Chemistry and Physics. 2020;221(20). doi:10.1002/macp.202000186 .
Babić, Marija M., Vukomanović, Marija, Stefanić, Martin, Nikodinović-Runić, Jasmina, Tomić, Simonida Lj., "Controlled Curcumin Release from Hydrogel Scaffold Platform Based on 2-Hydroxyethyl Methacrylate/Gelatin/Alginate/Iron(III) Oxide" in Macromolecular Chemistry and Physics, 221, no. 20 (2020), https://doi.org/10.1002/macp.202000186 . .