Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties
Нема приказа
Аутори
Tomić, Simonida Lj.Babić, Marija M.
Vuković, Jovana S.
Đokić, Lidija
Pavić, Aleksandar
Nikodinović-Runić, Jasmina
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
We have studied the effect of compositions and methods of preparation on the physico-chemical and biocompatible behavior of the hydrogel matrices. Hydrogel matrices are synthesized by free radical polymerization of 2-hydroxyethyl methacrylate net and with gelatin. Highly porous hydrogel structures were obtained by porogenation, and by cryogenic treatment followed by freeze-drying. All samples were characterized for structural, morphological, absorption, degradation and in vitro (healthy human fibroblast cell line) and in vivo (zebrafishDanio rerio) biocompatible properties. The obtained results show that cryo samples, especially with gelatin show better, favorable absorption, morphological and biocompatible properties in comparison with PHEMA samples, which makes these materials highly attractive for biomedical uses.
Кључне речи:
Morphology / Hydrogel / Gelatin / Biocompatible in vitro and in vivo properties / Absorption / 2-Hydroxyethyl methacrylateИзвор:
Journal of Polymer Research, 2020, 27, 10Издавач:
- Springer, Dordrecht
Финансирање / пројекти:
- SCOPES program of the Swiss National Science Foundation (SNSF)
- Swiss Agency for Development and Cooperation (SDC) [IZ73ZO_152327]
- Синтеза и карактеризација нових функционалних полимера и полимерних нанокомпозита (RS-MESTD-Basic Research (BR or ON)-172062)
- Хемијско и структурно дизајнирање наноматеријала за примену у медицини и инжењерству ткива (RS-MESTD-Basic Research (BR or ON)-172026)
DOI: 10.1007/s10965-020-02219-w
ISSN: 1022-9760
WoS: 000574616600002
Scopus: 2-s2.0-85091318852
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Tomić, Simonida Lj. AU - Babić, Marija M. AU - Vuković, Jovana S. AU - Đokić, Lidija AU - Pavić, Aleksandar AU - Nikodinović-Runić, Jasmina PY - 2020 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1361 AB - We have studied the effect of compositions and methods of preparation on the physico-chemical and biocompatible behavior of the hydrogel matrices. Hydrogel matrices are synthesized by free radical polymerization of 2-hydroxyethyl methacrylate net and with gelatin. Highly porous hydrogel structures were obtained by porogenation, and by cryogenic treatment followed by freeze-drying. All samples were characterized for structural, morphological, absorption, degradation and in vitro (healthy human fibroblast cell line) and in vivo (zebrafishDanio rerio) biocompatible properties. The obtained results show that cryo samples, especially with gelatin show better, favorable absorption, morphological and biocompatible properties in comparison with PHEMA samples, which makes these materials highly attractive for biomedical uses. PB - Springer, Dordrecht T2 - Journal of Polymer Research T1 - Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties IS - 10 VL - 27 DO - 10.1007/s10965-020-02219-w ER -
@article{ author = "Tomić, Simonida Lj. and Babić, Marija M. and Vuković, Jovana S. and Đokić, Lidija and Pavić, Aleksandar and Nikodinović-Runić, Jasmina", year = "2020", abstract = "We have studied the effect of compositions and methods of preparation on the physico-chemical and biocompatible behavior of the hydrogel matrices. Hydrogel matrices are synthesized by free radical polymerization of 2-hydroxyethyl methacrylate net and with gelatin. Highly porous hydrogel structures were obtained by porogenation, and by cryogenic treatment followed by freeze-drying. All samples were characterized for structural, morphological, absorption, degradation and in vitro (healthy human fibroblast cell line) and in vivo (zebrafishDanio rerio) biocompatible properties. The obtained results show that cryo samples, especially with gelatin show better, favorable absorption, morphological and biocompatible properties in comparison with PHEMA samples, which makes these materials highly attractive for biomedical uses.", publisher = "Springer, Dordrecht", journal = "Journal of Polymer Research", title = "Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties", number = "10", volume = "27", doi = "10.1007/s10965-020-02219-w" }
Tomić, S. Lj., Babić, M. M., Vuković, J. S., Đokić, L., Pavić, A.,& Nikodinović-Runić, J.. (2020). Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties. in Journal of Polymer Research Springer, Dordrecht., 27(10). https://doi.org/10.1007/s10965-020-02219-w
Tomić SL, Babić MM, Vuković JS, Đokić L, Pavić A, Nikodinović-Runić J. Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties. in Journal of Polymer Research. 2020;27(10). doi:10.1007/s10965-020-02219-w .
Tomić, Simonida Lj., Babić, Marija M., Vuković, Jovana S., Đokić, Lidija, Pavić, Aleksandar, Nikodinović-Runić, Jasmina, "Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties" in Journal of Polymer Research, 27, no. 10 (2020), https://doi.org/10.1007/s10965-020-02219-w . .