Design, synthesis and in vivo evaluation of 3-arylcoumarin derivatives of rhenium(I) tricarbonyl complexes as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)
2020
Аутори
Sovari, Sara NasiriVojnović, Sandra
Škaro Bogojević, Sanja
Crochet, Aurelien
Pavić, Aleksandar
Nikodinović-Runić, Jasmina
Zobi, Fabio
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
We have prepared a series of ten 3-arylcoumarin molecules, their respective fac-[Re(CO)(3)(bpy)L](+) and fac-[Re(CO)(3)(L(sic)L)Br] complexes and tested all compounds for their antimicrobial efficacy. Whereas the 3-arylcoumarin ligands are virtually inactive against the human-associated pathogens with minimum inhibitory concentrations (MICs) gt 150 mu M, when coordinated to the fac-[Re(CO)(3)](+) core, most of the resulting complexes showed remarkable antibacterial potency. Several rhenium complexes exhibit activity in nanomolar concentrations against Gram-positive pathogens such as Staphylococcus aureus strains, including methicillin-resistant S. aureus (MRSA) and Enterococcus faecium. The molecules do not affect bacterial cell membrane potential, but some of the most potent complexes strongly interact with DNA, indicating it as a possible target for their mode of action. In vivo studies in the zebrafish model showed that the complexes with anti-staphylococcal/MRSA activity were non...-toxic to the organism even at much higher doses of the corresponding MICs. In the zebrafish-MRSA infection model, the complexes increased the survival rate of infected fish up to 100% and markedly reduced bacterial burden. Moreover, all rescued fish developed normally following the treatments with the metallic compounds.
Кључне речи:
Staphylococcus aureus / Rhenium(I) tricarbonyl complex / MRSA / AntibioticИзвор:
European Journal of Medicinal Chemistry, 2020, 205Издавач:
- Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
Финансирање / пројекти:
- University of Fribourg
- Изучавање микробиолошког диверзитета и карактеризација корисних срединских микроорганизама (RS-MESTD-Basic Research (BR or ON)-173048)
DOI: 10.1016/j.ejmech.2020.112533
ISSN: 0223-5234
PubMed: 32739550
WoS: 000578986400004
Scopus: 2-s2.0-85088652851
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Sovari, Sara Nasiri AU - Vojnović, Sandra AU - Škaro Bogojević, Sanja AU - Crochet, Aurelien AU - Pavić, Aleksandar AU - Nikodinović-Runić, Jasmina AU - Zobi, Fabio PY - 2020 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1365 AB - We have prepared a series of ten 3-arylcoumarin molecules, their respective fac-[Re(CO)(3)(bpy)L](+) and fac-[Re(CO)(3)(L(sic)L)Br] complexes and tested all compounds for their antimicrobial efficacy. Whereas the 3-arylcoumarin ligands are virtually inactive against the human-associated pathogens with minimum inhibitory concentrations (MICs) gt 150 mu M, when coordinated to the fac-[Re(CO)(3)](+) core, most of the resulting complexes showed remarkable antibacterial potency. Several rhenium complexes exhibit activity in nanomolar concentrations against Gram-positive pathogens such as Staphylococcus aureus strains, including methicillin-resistant S. aureus (MRSA) and Enterococcus faecium. The molecules do not affect bacterial cell membrane potential, but some of the most potent complexes strongly interact with DNA, indicating it as a possible target for their mode of action. In vivo studies in the zebrafish model showed that the complexes with anti-staphylococcal/MRSA activity were non-toxic to the organism even at much higher doses of the corresponding MICs. In the zebrafish-MRSA infection model, the complexes increased the survival rate of infected fish up to 100% and markedly reduced bacterial burden. Moreover, all rescued fish developed normally following the treatments with the metallic compounds. PB - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux T2 - European Journal of Medicinal Chemistry T1 - Design, synthesis and in vivo evaluation of 3-arylcoumarin derivatives of rhenium(I) tricarbonyl complexes as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) VL - 205 DO - 10.1016/j.ejmech.2020.112533 ER -
@article{ author = "Sovari, Sara Nasiri and Vojnović, Sandra and Škaro Bogojević, Sanja and Crochet, Aurelien and Pavić, Aleksandar and Nikodinović-Runić, Jasmina and Zobi, Fabio", year = "2020", abstract = "We have prepared a series of ten 3-arylcoumarin molecules, their respective fac-[Re(CO)(3)(bpy)L](+) and fac-[Re(CO)(3)(L(sic)L)Br] complexes and tested all compounds for their antimicrobial efficacy. Whereas the 3-arylcoumarin ligands are virtually inactive against the human-associated pathogens with minimum inhibitory concentrations (MICs) gt 150 mu M, when coordinated to the fac-[Re(CO)(3)](+) core, most of the resulting complexes showed remarkable antibacterial potency. Several rhenium complexes exhibit activity in nanomolar concentrations against Gram-positive pathogens such as Staphylococcus aureus strains, including methicillin-resistant S. aureus (MRSA) and Enterococcus faecium. The molecules do not affect bacterial cell membrane potential, but some of the most potent complexes strongly interact with DNA, indicating it as a possible target for their mode of action. In vivo studies in the zebrafish model showed that the complexes with anti-staphylococcal/MRSA activity were non-toxic to the organism even at much higher doses of the corresponding MICs. In the zebrafish-MRSA infection model, the complexes increased the survival rate of infected fish up to 100% and markedly reduced bacterial burden. Moreover, all rescued fish developed normally following the treatments with the metallic compounds.", publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux", journal = "European Journal of Medicinal Chemistry", title = "Design, synthesis and in vivo evaluation of 3-arylcoumarin derivatives of rhenium(I) tricarbonyl complexes as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)", volume = "205", doi = "10.1016/j.ejmech.2020.112533" }
Sovari, S. N., Vojnović, S., Škaro Bogojević, S., Crochet, A., Pavić, A., Nikodinović-Runić, J.,& Zobi, F.. (2020). Design, synthesis and in vivo evaluation of 3-arylcoumarin derivatives of rhenium(I) tricarbonyl complexes as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). in European Journal of Medicinal Chemistry Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 205. https://doi.org/10.1016/j.ejmech.2020.112533
Sovari SN, Vojnović S, Škaro Bogojević S, Crochet A, Pavić A, Nikodinović-Runić J, Zobi F. Design, synthesis and in vivo evaluation of 3-arylcoumarin derivatives of rhenium(I) tricarbonyl complexes as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). in European Journal of Medicinal Chemistry. 2020;205. doi:10.1016/j.ejmech.2020.112533 .
Sovari, Sara Nasiri, Vojnović, Sandra, Škaro Bogojević, Sanja, Crochet, Aurelien, Pavić, Aleksandar, Nikodinović-Runić, Jasmina, Zobi, Fabio, "Design, synthesis and in vivo evaluation of 3-arylcoumarin derivatives of rhenium(I) tricarbonyl complexes as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)" in European Journal of Medicinal Chemistry, 205 (2020), https://doi.org/10.1016/j.ejmech.2020.112533 . .