Insights into platinum-induced peripheral neuropathy-current perspective
Апстракт
Cancer is a global health problem that is often successfully addressed by therapy, with cancer survivors increasing in numbers and living longer world around. Although new cancer treatment options are continuously explored, platinum based chemotherapy agents remain in use due to their efficiency and availability. Unfortunately, all cancer therapies affect normal tissues as well as cancer, and more than 40 specific side effects of platinum based drugs documented so far decrease the quality of life of cancer survivors. Chemotherapy-induced peripheral neuropathy is a frequent side effects of platinum-based chemotherapy agents. This cluster of complications is often so debilitating that patients occasionally have to discontinue the therapy. Sensory neurons of dorsal root ganglia are at the core of chemotherapy-induced peripheral neuropathy symptoms. In these postmitotic cells, DNA damage caused by platinum chemotherapy interferes with normal functioning. Accumulation of DNA-platinum adduct...s correlates with neurotoxic severity and development of sensation of pain. While biochemistry of DNA-platinum adducts is the same in all cell types, molecular mechanisms affected by DNA-platinum adducts are different in cancer cells and non-dividing cells. This review aims to raise awareness about platinum associated chemotherapy-induced peripheral neuropathy as a medical problem that has remained unexplained for decades. We emphasize the complexity of this condition both from clinical and mechanistical point of view and focus on recent findings about chemotherapy-induced peripheral neuropathy in in vitro and in vivo model systems. Finally, we summarize current perspectives about clinical approaches for chemotherapy-induced peripheral neuropathy treatment.
Кључне речи:
side effects / sensory neurons treatment / Pt / platinum based chemotherapy / neurotoxic / molecular mechanisms / model systems / DRG / dorsal root ganglia / DNA-Pt adducts / CIPN / chemotherapy-induced peripheral neuropathyИзвор:
Neural Regeneration Research, 2020, 15, 9, 1623-1630Издавач:
- Wolters Kluwer Medknow Publications, Mumbai
Финансирање / пројекти:
- Проучавање сигналних путева и епигенетичких механизама укључених у контролу експресије хуманих SOX гена: даље расветљавање њихове улоге у одређивању судбине и диференцијацији ћелија (RS-MESTD-Basic Research (BR or ON)-173051)
- UICC Yamagiwa-Yoshida Memorial International Cancer Study Grant [YY2/2015/381414]
DOI: 10.4103/1673-5374.276321
ISSN: 1673-5374
WoS: 000519115200006
Scopus: 2-s2.0-85081327140
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Lazić, Andrijana AU - Popović, Jelena AU - Paunesku, Tatjana AU - Woloschak, Gayle E. AU - Stevanović, Milena PY - 2020 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1385 AB - Cancer is a global health problem that is often successfully addressed by therapy, with cancer survivors increasing in numbers and living longer world around. Although new cancer treatment options are continuously explored, platinum based chemotherapy agents remain in use due to their efficiency and availability. Unfortunately, all cancer therapies affect normal tissues as well as cancer, and more than 40 specific side effects of platinum based drugs documented so far decrease the quality of life of cancer survivors. Chemotherapy-induced peripheral neuropathy is a frequent side effects of platinum-based chemotherapy agents. This cluster of complications is often so debilitating that patients occasionally have to discontinue the therapy. Sensory neurons of dorsal root ganglia are at the core of chemotherapy-induced peripheral neuropathy symptoms. In these postmitotic cells, DNA damage caused by platinum chemotherapy interferes with normal functioning. Accumulation of DNA-platinum adducts correlates with neurotoxic severity and development of sensation of pain. While biochemistry of DNA-platinum adducts is the same in all cell types, molecular mechanisms affected by DNA-platinum adducts are different in cancer cells and non-dividing cells. This review aims to raise awareness about platinum associated chemotherapy-induced peripheral neuropathy as a medical problem that has remained unexplained for decades. We emphasize the complexity of this condition both from clinical and mechanistical point of view and focus on recent findings about chemotherapy-induced peripheral neuropathy in in vitro and in vivo model systems. Finally, we summarize current perspectives about clinical approaches for chemotherapy-induced peripheral neuropathy treatment. PB - Wolters Kluwer Medknow Publications, Mumbai T2 - Neural Regeneration Research T1 - Insights into platinum-induced peripheral neuropathy-current perspective EP - 1630 IS - 9 SP - 1623 VL - 15 DO - 10.4103/1673-5374.276321 ER -
@article{ author = "Lazić, Andrijana and Popović, Jelena and Paunesku, Tatjana and Woloschak, Gayle E. and Stevanović, Milena", year = "2020", abstract = "Cancer is a global health problem that is often successfully addressed by therapy, with cancer survivors increasing in numbers and living longer world around. Although new cancer treatment options are continuously explored, platinum based chemotherapy agents remain in use due to their efficiency and availability. Unfortunately, all cancer therapies affect normal tissues as well as cancer, and more than 40 specific side effects of platinum based drugs documented so far decrease the quality of life of cancer survivors. Chemotherapy-induced peripheral neuropathy is a frequent side effects of platinum-based chemotherapy agents. This cluster of complications is often so debilitating that patients occasionally have to discontinue the therapy. Sensory neurons of dorsal root ganglia are at the core of chemotherapy-induced peripheral neuropathy symptoms. In these postmitotic cells, DNA damage caused by platinum chemotherapy interferes with normal functioning. Accumulation of DNA-platinum adducts correlates with neurotoxic severity and development of sensation of pain. While biochemistry of DNA-platinum adducts is the same in all cell types, molecular mechanisms affected by DNA-platinum adducts are different in cancer cells and non-dividing cells. This review aims to raise awareness about platinum associated chemotherapy-induced peripheral neuropathy as a medical problem that has remained unexplained for decades. We emphasize the complexity of this condition both from clinical and mechanistical point of view and focus on recent findings about chemotherapy-induced peripheral neuropathy in in vitro and in vivo model systems. Finally, we summarize current perspectives about clinical approaches for chemotherapy-induced peripheral neuropathy treatment.", publisher = "Wolters Kluwer Medknow Publications, Mumbai", journal = "Neural Regeneration Research", title = "Insights into platinum-induced peripheral neuropathy-current perspective", pages = "1630-1623", number = "9", volume = "15", doi = "10.4103/1673-5374.276321" }
Lazić, A., Popović, J., Paunesku, T., Woloschak, G. E.,& Stevanović, M.. (2020). Insights into platinum-induced peripheral neuropathy-current perspective. in Neural Regeneration Research Wolters Kluwer Medknow Publications, Mumbai., 15(9), 1623-1630. https://doi.org/10.4103/1673-5374.276321
Lazić A, Popović J, Paunesku T, Woloschak GE, Stevanović M. Insights into platinum-induced peripheral neuropathy-current perspective. in Neural Regeneration Research. 2020;15(9):1623-1630. doi:10.4103/1673-5374.276321 .
Lazić, Andrijana, Popović, Jelena, Paunesku, Tatjana, Woloschak, Gayle E., Stevanović, Milena, "Insights into platinum-induced peripheral neuropathy-current perspective" in Neural Regeneration Research, 15, no. 9 (2020):1623-1630, https://doi.org/10.4103/1673-5374.276321 . .