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Evaluation of global haemostatic assays and fibrin structure in patients with pre-eclampsia
dc.creator | Lalić-Cosić, Sanja | |
dc.creator | Dopsaj, Violeta | |
dc.creator | Kovač, Mirjana | |
dc.creator | Pruner, Iva | |
dc.creator | Littmann, Karin | |
dc.creator | Mandić-Marković, Vesna | |
dc.creator | Miković, Zeljko | |
dc.creator | Antović, Aleksandra | |
dc.date.accessioned | 2022-11-15T15:17:29Z | |
dc.date.available | 2022-11-15T15:17:29Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1751-5521 | |
dc.identifier.uri | https://imagine.imgge.bg.ac.rs/handle/123456789/1390 | |
dc.description.abstract | Introduction Haemostatic balance shifted towards hypercoagulability in normal pregnancy is even more pronounced in pre-eclampsia (P-EC). The aim of this study was to analyse haemostatic disturbances and fibrin clot properties in women with pre-eclampsia and to investigate their association with maternal and foetal outcomes. Methods Forty-six pregnant women diagnosed with pre-eclampsia were included in the study, with blood sampling done on the morning following admission to hospital, as well as after delivery (mean duration 4.8 days). Two global haemostatic assays-endogenous thrombin potential (ETP) and assay of overall haemostatic potential (OHP)-were employed, including fibrin clot turbidity measurements and scanning electron microscopy (SEM) of representative samples. Results Three thrombin generation parameters (ETP, t_lag and peak height) and OHP were significantly increased in pre-eclampsia compared with controls, whereas overall fibrinolytic potential (OFP-determined as a parameter of the OHP assay) had significantly lower values. Clot lysis time was significantly prolonged in patients with pre-eclampsia. In the pre-eclamptic group after delivery, we observed a significant elevation in the peak height and a reduction in the time to peak and OFP compared with values before delivery. Pre-eclamptic patients with renal complications had significantly higher values for ETP, peak height and D-dimer. Turbidity measurements and SEM revealed dense fibrin structure in patients with pre-eclampsia. Conclusion Patients with pre-eclampsia have enhanced coagulation and impaired fibrinolysis before, and even after, delivery. In particular, the presence of multi-organ dysfunction, such as renal dysfunction, may be associated with increased thrombin generation in pre-eclampsia. | en |
dc.publisher | Wiley, Hoboken | |
dc.rights | restrictedAccess | |
dc.source | International Journal of Laboratory Hematology | |
dc.subject | pre-eclampsia | en |
dc.subject | overall haemostatic potential | en |
dc.subject | haemostasis | en |
dc.subject | fibrin structure | en |
dc.subject | endogenous thrombin potential | en |
dc.title | Evaluation of global haemostatic assays and fibrin structure in patients with pre-eclampsia | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 330 | |
dc.citation.issue | 3 | |
dc.citation.other | 42(3): 322-330 | |
dc.citation.rank | M23 | |
dc.citation.spage | 322 | |
dc.citation.volume | 42 | |
dc.identifier.doi | 10.1111/ijlh.13183 | |
dc.identifier.pmid | 32190981 | |
dc.identifier.scopus | 2-s2.0-85082040715 | |
dc.identifier.wos | 000520544100001 | |
dc.type.version | publishedVersion |
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