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Metabolic Syndrome in Inflammatory Bowel Disease: Association with Genetic Markers of Obesity and Inflammation
dc.creator | Dragasević, Sanja | |
dc.creator | Stanković, Biljana | |
dc.creator | Kotur, Nikola | |
dc.creator | Sokić-Milutinović, Aleksandra | |
dc.creator | Milovanović, Tamara | |
dc.creator | Lukić, Snežana | |
dc.creator | Milosavljević, Tomica | |
dc.creator | Srzentić Dražilov, Sanja | |
dc.creator | Klaassen, Kristel | |
dc.creator | Pavlović, Sonja | |
dc.creator | Popović, Dragan | |
dc.date.accessioned | 2022-11-15T15:18:05Z | |
dc.date.available | 2022-11-15T15:18:05Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1540-4196 | |
dc.identifier.uri | https://imagine.imgge.bg.ac.rs/handle/123456789/1398 | |
dc.description.abstract | Background: This study analyzed poorly understood relationship of two overlapping conditions: metabolic syndrome (MeS) and inflammatory bowel disease (IBD), both associated with inflammation in the visceral adipose tissue. Methods: Newly diagnosed 104 IBD patients, of which 50 Crohn's disease (CD) and 54 ulcerative colitis (UC), and 45 non-IBD controls were examined for MeS-related obesity and lipid markers. Th-17 immune genes IL17A, IL17F, IL23A, and TLR9 mRNAs were measured in intestinal mucosa by qRT-PCR. Subjects were genotyped for obesity-associated FTO variant rs9939609 by polymerase chain reaction-amplification refractory mutation system. Results: CD was associated with MeS (P = 0.01), while both CD and UC were associated with central obesity (P = 10(-5), P = 0.002, respectively) and low levels of high-density lipoprotein (HDL) cholesterol (P = 5 x 10(-6), P = 6 x 10(-6), respectively). IBD lipid profile was characterized by decreased total and HDL cholesterol, while low-density lipoprotein cholesterol was reduced only in CD. Negative correlations were found between total cholesterol and CD activity index (P = 0.005), waist circumference and IL17A as well as IL17F mRNA levels in inflamed CD colon (P = 0.003, P = 0.001, respectively). Carriers of FTO rs9939609 AA genotype showed increased risk of CD (OR 2.6, P = 0.01). Conclusions: MeS, central obesity, and dyslipidemia could be important for IBD pathogenesis. This could influence therapeutic approaches and prevention strategies in high-risk groups. | en |
dc.publisher | Mary Ann Liebert, Inc, New Rochelle | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41004/RS// | |
dc.rights | restrictedAccess | |
dc.source | Metabolic Syndrome and Related Disorders | |
dc.subject | Th-17 genes expression | en |
dc.subject | IBD | en |
dc.subject | FTO | en |
dc.subject | dyslipidemia | en |
dc.subject | central obesity | en |
dc.title | Metabolic Syndrome in Inflammatory Bowel Disease: Association with Genetic Markers of Obesity and Inflammation | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 38 | |
dc.citation.issue | 1 | |
dc.citation.other | 18(1): 31-38 | |
dc.citation.rank | M23 | |
dc.citation.spage | 31 | |
dc.citation.volume | 18 | |
dc.identifier.doi | 10.1089/met.2019.0090 | |
dc.identifier.pmid | 31750766 | |
dc.identifier.scopus | 2-s2.0-85078868612 | |
dc.identifier.wos | 000497706400001 | |
dc.type.version | publishedVersion |
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