Synthesis and Biological Screening of New 4-Hydroxycoumarin Derivatives and Their Palladium(II) Complexes
Аутори
Avdović, Edina H.Petrović, Isidora
Stevanović, Milena
Saso, Luciano
Dimitrić Marković, Jasmina M.
Filipović, Nenad D.
Zivić, Miroslav Z.
Cvetić Antić, Tijana N.
Zizić, Milan V.
Todorović, Nataša V.
Vukić, Milena
Trifunović, Srecko R.
Marković, Zoran S.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Two newly synthesized 4-hydroxycoumarin bidentate ligands (L1 and L2) and their palladium(II) complexes (C1 and C2) were screened for their biological activities, in vitro and in vivo. Structures of new compounds were established based on elemental analysis, H-1 NMR, C-13 NMR, and IR spectroscopic techniques. The obtained compounds were tested for their antioxidative and cytotoxic activities and results pointed to selective antiradical activity of palladium(II) complexes towards (OH)-O-center dot and -center dot OOH radicals and anti-ABTS (2,2 '-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) cation radical) activity comparable to that of ascorbate. Results indicated the effect of C1 and C2 on the enzymatic activity of the antioxidative defense system. In vitro cytotoxicity assay performed on different carcinoma cell lines (HCT166, A375, and MIA PaCa-2), and one healthy fibroblast cell line (MRC-5) showed a cytotoxic effect of both C1 and C2, expressed as a decrease in carcinoma cell...s' viability, mostly by induction of apoptosis. In vivo toxicity tests performed on zebrafish embryos indicated different effects of C1 and C2, ranging from adverse developmental effect to no toxicity, depending on tested concentration. According to docking studies, both complexes (C1 and C2) showed better inhibitory activity in comparison to other palladium(II) complexes.
Извор:
Oxidative Medicine and Cellular Longevity, 2021, 2021Издавач:
- Hindawi Ltd, London
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200378 (Институт за информационе технологије, Крагујевац) (RS-MESTD-inst-2020-200378)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200122 (Универзитет у Крагујевцу, Природно-математички факултет) (RS-MESTD-inst-2020-200122)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200042 (Универзитет у Београду, Институт за молекуларну генетику и генетичко инжењерство) (RS-MESTD-inst-2020-200042)
DOI: 10.1155/2021/8849568
ISSN: 1942-0900
PubMed: 34007407
WoS: 000664969600003
Scopus: 2-s2.0-85105724813
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Avdović, Edina H. AU - Petrović, Isidora AU - Stevanović, Milena AU - Saso, Luciano AU - Dimitrić Marković, Jasmina M. AU - Filipović, Nenad D. AU - Zivić, Miroslav Z. AU - Cvetić Antić, Tijana N. AU - Zizić, Milan V. AU - Todorović, Nataša V. AU - Vukić, Milena AU - Trifunović, Srecko R. AU - Marković, Zoran S. PY - 2021 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1443 AB - Two newly synthesized 4-hydroxycoumarin bidentate ligands (L1 and L2) and their palladium(II) complexes (C1 and C2) were screened for their biological activities, in vitro and in vivo. Structures of new compounds were established based on elemental analysis, H-1 NMR, C-13 NMR, and IR spectroscopic techniques. The obtained compounds were tested for their antioxidative and cytotoxic activities and results pointed to selective antiradical activity of palladium(II) complexes towards (OH)-O-center dot and -center dot OOH radicals and anti-ABTS (2,2 '-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) cation radical) activity comparable to that of ascorbate. Results indicated the effect of C1 and C2 on the enzymatic activity of the antioxidative defense system. In vitro cytotoxicity assay performed on different carcinoma cell lines (HCT166, A375, and MIA PaCa-2), and one healthy fibroblast cell line (MRC-5) showed a cytotoxic effect of both C1 and C2, expressed as a decrease in carcinoma cells' viability, mostly by induction of apoptosis. In vivo toxicity tests performed on zebrafish embryos indicated different effects of C1 and C2, ranging from adverse developmental effect to no toxicity, depending on tested concentration. According to docking studies, both complexes (C1 and C2) showed better inhibitory activity in comparison to other palladium(II) complexes. PB - Hindawi Ltd, London T2 - Oxidative Medicine and Cellular Longevity T1 - Synthesis and Biological Screening of New 4-Hydroxycoumarin Derivatives and Their Palladium(II) Complexes VL - 2021 DO - 10.1155/2021/8849568 ER -
@article{ author = "Avdović, Edina H. and Petrović, Isidora and Stevanović, Milena and Saso, Luciano and Dimitrić Marković, Jasmina M. and Filipović, Nenad D. and Zivić, Miroslav Z. and Cvetić Antić, Tijana N. and Zizić, Milan V. and Todorović, Nataša V. and Vukić, Milena and Trifunović, Srecko R. and Marković, Zoran S.", year = "2021", abstract = "Two newly synthesized 4-hydroxycoumarin bidentate ligands (L1 and L2) and their palladium(II) complexes (C1 and C2) were screened for their biological activities, in vitro and in vivo. Structures of new compounds were established based on elemental analysis, H-1 NMR, C-13 NMR, and IR spectroscopic techniques. The obtained compounds were tested for their antioxidative and cytotoxic activities and results pointed to selective antiradical activity of palladium(II) complexes towards (OH)-O-center dot and -center dot OOH radicals and anti-ABTS (2,2 '-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) cation radical) activity comparable to that of ascorbate. Results indicated the effect of C1 and C2 on the enzymatic activity of the antioxidative defense system. In vitro cytotoxicity assay performed on different carcinoma cell lines (HCT166, A375, and MIA PaCa-2), and one healthy fibroblast cell line (MRC-5) showed a cytotoxic effect of both C1 and C2, expressed as a decrease in carcinoma cells' viability, mostly by induction of apoptosis. In vivo toxicity tests performed on zebrafish embryos indicated different effects of C1 and C2, ranging from adverse developmental effect to no toxicity, depending on tested concentration. According to docking studies, both complexes (C1 and C2) showed better inhibitory activity in comparison to other palladium(II) complexes.", publisher = "Hindawi Ltd, London", journal = "Oxidative Medicine and Cellular Longevity", title = "Synthesis and Biological Screening of New 4-Hydroxycoumarin Derivatives and Their Palladium(II) Complexes", volume = "2021", doi = "10.1155/2021/8849568" }
Avdović, E. H., Petrović, I., Stevanović, M., Saso, L., Dimitrić Marković, J. M., Filipović, N. D., Zivić, M. Z., Cvetić Antić, T. N., Zizić, M. V., Todorović, N. V., Vukić, M., Trifunović, S. R.,& Marković, Z. S.. (2021). Synthesis and Biological Screening of New 4-Hydroxycoumarin Derivatives and Their Palladium(II) Complexes. in Oxidative Medicine and Cellular Longevity Hindawi Ltd, London., 2021. https://doi.org/10.1155/2021/8849568
Avdović EH, Petrović I, Stevanović M, Saso L, Dimitrić Marković JM, Filipović ND, Zivić MZ, Cvetić Antić TN, Zizić MV, Todorović NV, Vukić M, Trifunović SR, Marković ZS. Synthesis and Biological Screening of New 4-Hydroxycoumarin Derivatives and Their Palladium(II) Complexes. in Oxidative Medicine and Cellular Longevity. 2021;2021. doi:10.1155/2021/8849568 .
Avdović, Edina H., Petrović, Isidora, Stevanović, Milena, Saso, Luciano, Dimitrić Marković, Jasmina M., Filipović, Nenad D., Zivić, Miroslav Z., Cvetić Antić, Tijana N., Zizić, Milan V., Todorović, Nataša V., Vukić, Milena, Trifunović, Srecko R., Marković, Zoran S., "Synthesis and Biological Screening of New 4-Hydroxycoumarin Derivatives and Their Palladium(II) Complexes" in Oxidative Medicine and Cellular Longevity, 2021 (2021), https://doi.org/10.1155/2021/8849568 . .