Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite
Authors
Tomić, Simonida LjNikodinović-Runić, Jasmina
Vukomanović, Marija
Babić, Marija M.
Vuković, Jovana S.
Article (Published version)
Metadata
Show full item recordAbstract
Hydrogel scaffolding biomaterials are one of the most attractive polymeric biomaterials for regenerative engineering and can be engineered into tissue mimetic scaffolds to support cell growth due to their similarity to the native extracellular matrix. The novel, versatile hydrogel scaffolds based on alginate, gelatin, 2-hydroxyethyl methacrylate, and inorganic agent hydroxyapatite were prepared by modified cryogelation. The chemical composition, morphology, porosity, mechanical properties, effects on cell viability, in vitro degradation, in vitro and in vivo biocompatibility were tested to correlate the material's composition with the corresponding properties. Scaffolds showed an interconnected porous microstructure, satisfactory mechanical strength, favorable hydrophilicity, degradation, and suitable in vitro and in vivo biocompatible behavior. Materials showed good biocompatibility with healthy human fibroblast in cell culture, as well as in vivo with zebrafish assay, suggesting newl...y synthesized hydrogel scaffolds as a potential new generation of hydrogel scaffolding biomaterials with tunable properties for versatile biomedical applications and tissue regeneration.
Keywords:
tissue regeneration engineering / hydroxyapatite / hydrogel scaffolding biomaterial / gelatin / degradable scaffolds / biocompatibility / alginate / 2-hydroxyethyl methacrylateSource:
Polymers, 2021, 13, 6Publisher:
- MDPI, Basel
Funding / projects:
- SCOPES program of the Swiss National Science Foundation (SNSF)
- Swiss Agency for Development and Cooperation (SDC) [IZ73ZO_152327]
- Synthesis and characterization of novel functional polymers and polymeric nanocomposites (RS-MESTD-Basic Research (BR or ON)-172062)
- Chemical and structural designing of nanomaterials for application in medicine and tissue engineering (RS-MESTD-Basic Research (BR or ON)-172026)
DOI: 10.3390/polym13060932
ISSN: 2073-4360
WoS: 000651944700001
Scopus: 2-s2.0-85103494235
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Tomić, Simonida Lj AU - Nikodinović-Runić, Jasmina AU - Vukomanović, Marija AU - Babić, Marija M. AU - Vuković, Jovana S. PY - 2021 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1450 AB - Hydrogel scaffolding biomaterials are one of the most attractive polymeric biomaterials for regenerative engineering and can be engineered into tissue mimetic scaffolds to support cell growth due to their similarity to the native extracellular matrix. The novel, versatile hydrogel scaffolds based on alginate, gelatin, 2-hydroxyethyl methacrylate, and inorganic agent hydroxyapatite were prepared by modified cryogelation. The chemical composition, morphology, porosity, mechanical properties, effects on cell viability, in vitro degradation, in vitro and in vivo biocompatibility were tested to correlate the material's composition with the corresponding properties. Scaffolds showed an interconnected porous microstructure, satisfactory mechanical strength, favorable hydrophilicity, degradation, and suitable in vitro and in vivo biocompatible behavior. Materials showed good biocompatibility with healthy human fibroblast in cell culture, as well as in vivo with zebrafish assay, suggesting newly synthesized hydrogel scaffolds as a potential new generation of hydrogel scaffolding biomaterials with tunable properties for versatile biomedical applications and tissue regeneration. PB - MDPI, Basel T2 - Polymers T1 - Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite IS - 6 VL - 13 DO - 10.3390/polym13060932 ER -
@article{ author = "Tomić, Simonida Lj and Nikodinović-Runić, Jasmina and Vukomanović, Marija and Babić, Marija M. and Vuković, Jovana S.", year = "2021", abstract = "Hydrogel scaffolding biomaterials are one of the most attractive polymeric biomaterials for regenerative engineering and can be engineered into tissue mimetic scaffolds to support cell growth due to their similarity to the native extracellular matrix. The novel, versatile hydrogel scaffolds based on alginate, gelatin, 2-hydroxyethyl methacrylate, and inorganic agent hydroxyapatite were prepared by modified cryogelation. The chemical composition, morphology, porosity, mechanical properties, effects on cell viability, in vitro degradation, in vitro and in vivo biocompatibility were tested to correlate the material's composition with the corresponding properties. Scaffolds showed an interconnected porous microstructure, satisfactory mechanical strength, favorable hydrophilicity, degradation, and suitable in vitro and in vivo biocompatible behavior. Materials showed good biocompatibility with healthy human fibroblast in cell culture, as well as in vivo with zebrafish assay, suggesting newly synthesized hydrogel scaffolds as a potential new generation of hydrogel scaffolding biomaterials with tunable properties for versatile biomedical applications and tissue regeneration.", publisher = "MDPI, Basel", journal = "Polymers", title = "Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite", number = "6", volume = "13", doi = "10.3390/polym13060932" }
Tomić, S. L., Nikodinović-Runić, J., Vukomanović, M., Babić, M. M.,& Vuković, J. S.. (2021). Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite. in Polymers MDPI, Basel., 13(6). https://doi.org/10.3390/polym13060932
Tomić SL, Nikodinović-Runić J, Vukomanović M, Babić MM, Vuković JS. Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite. in Polymers. 2021;13(6). doi:10.3390/polym13060932 .
Tomić, Simonida Lj, Nikodinović-Runić, Jasmina, Vukomanović, Marija, Babić, Marija M., Vuković, Jovana S., "Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite" in Polymers, 13, no. 6 (2021), https://doi.org/10.3390/polym13060932 . .