SOX transcription factors and glioma stem cells: Choosing between stemness and differentiation
2021
Authors
Stevanović, MilenaKovačević Grujičić, Nataša
Mojsin, Marija
Milivojević, Milena
Drakulić, Danijela
Article (Published version)
Metadata
Show full item recordAbstract
Glioblastoma (GBM) is the most common, most aggressive and deadliest brain tumor. Recently, remarkable progress has been made towards understanding the cellular and molecular biology of gliomas. GBM tumor initiation, progression and relapse as well as resistance to treatments are associated with glioma stem cells (GSCs). GSCs exhibit a high proliferation rate and self-renewal capacity and the ability to differentiate into diverse cell types, generating a range of distinct cell types within the tumor, leading to cellular heterogeneity. GBM tumors may contain different subsets of GSCs, and some of them may adopt a quiescent state that protects them against chemotherapy and radiotherapy. GSCs enriched in recurrent gliomas acquire more aggressive and therapy-resistant properties, making them more malignant, able to rapidly spread. The impact of SOX transcription factors (TFs) on brain tumors has been extensively studied in the last decade. Almost all SOX genes are expressed in GBM, and the...ir expression levels are associated with patient prognosis and survival. Numerous SOX TFs are involved in the maintenance of the stemness of GSCs or play a role in the initiation of GSC differentiation. The fine-tuning of SOX gene expression levels controls the balance between cell stemness and differentiation. Therefore, innovative therapies targeting SOX TFs are emerging as promising tools for combatting GBM. Combatting GBM has been a demanding and challenging goal for decades. The current therapeutic strategies have not yet provided a cure for GBM and have only resulted in a slight improvement in patient survival. Novel approaches will require the fine adjustment of multimodal therapeutic strategies that simultaneously target numerous hallmarks of cancer cells to win the battle against GBM.
Keywords:
Stemness / SOX transcription factors / Glioma stem cells / Glioblastoma / DifferentiationSource:
World Journal of Stem Cells, 2021, 13, 10, 1417-1445Publisher:
- Baishideng Publishing Group Inc, Pleasanton
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200042 (University of Belgrade, Institute of Molecular Genetics and Genetic Engineering) (RS-MESTD-inst-2020-200042)
DOI: 10.4252/wjsc.v13.i10.1417
ISSN: 1948-0210
WoS: 000721497800004
Scopus: 2-s2.0-85119901335
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Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Stevanović, Milena AU - Kovačević Grujičić, Nataša AU - Mojsin, Marija AU - Milivojević, Milena AU - Drakulić, Danijela PY - 2021 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1468 AB - Glioblastoma (GBM) is the most common, most aggressive and deadliest brain tumor. Recently, remarkable progress has been made towards understanding the cellular and molecular biology of gliomas. GBM tumor initiation, progression and relapse as well as resistance to treatments are associated with glioma stem cells (GSCs). GSCs exhibit a high proliferation rate and self-renewal capacity and the ability to differentiate into diverse cell types, generating a range of distinct cell types within the tumor, leading to cellular heterogeneity. GBM tumors may contain different subsets of GSCs, and some of them may adopt a quiescent state that protects them against chemotherapy and radiotherapy. GSCs enriched in recurrent gliomas acquire more aggressive and therapy-resistant properties, making them more malignant, able to rapidly spread. The impact of SOX transcription factors (TFs) on brain tumors has been extensively studied in the last decade. Almost all SOX genes are expressed in GBM, and their expression levels are associated with patient prognosis and survival. Numerous SOX TFs are involved in the maintenance of the stemness of GSCs or play a role in the initiation of GSC differentiation. The fine-tuning of SOX gene expression levels controls the balance between cell stemness and differentiation. Therefore, innovative therapies targeting SOX TFs are emerging as promising tools for combatting GBM. Combatting GBM has been a demanding and challenging goal for decades. The current therapeutic strategies have not yet provided a cure for GBM and have only resulted in a slight improvement in patient survival. Novel approaches will require the fine adjustment of multimodal therapeutic strategies that simultaneously target numerous hallmarks of cancer cells to win the battle against GBM. PB - Baishideng Publishing Group Inc, Pleasanton T2 - World Journal of Stem Cells T1 - SOX transcription factors and glioma stem cells: Choosing between stemness and differentiation EP - 1445 IS - 10 SP - 1417 VL - 13 DO - 10.4252/wjsc.v13.i10.1417 ER -
@article{ author = "Stevanović, Milena and Kovačević Grujičić, Nataša and Mojsin, Marija and Milivojević, Milena and Drakulić, Danijela", year = "2021", abstract = "Glioblastoma (GBM) is the most common, most aggressive and deadliest brain tumor. Recently, remarkable progress has been made towards understanding the cellular and molecular biology of gliomas. GBM tumor initiation, progression and relapse as well as resistance to treatments are associated with glioma stem cells (GSCs). GSCs exhibit a high proliferation rate and self-renewal capacity and the ability to differentiate into diverse cell types, generating a range of distinct cell types within the tumor, leading to cellular heterogeneity. GBM tumors may contain different subsets of GSCs, and some of them may adopt a quiescent state that protects them against chemotherapy and radiotherapy. GSCs enriched in recurrent gliomas acquire more aggressive and therapy-resistant properties, making them more malignant, able to rapidly spread. The impact of SOX transcription factors (TFs) on brain tumors has been extensively studied in the last decade. Almost all SOX genes are expressed in GBM, and their expression levels are associated with patient prognosis and survival. Numerous SOX TFs are involved in the maintenance of the stemness of GSCs or play a role in the initiation of GSC differentiation. The fine-tuning of SOX gene expression levels controls the balance between cell stemness and differentiation. Therefore, innovative therapies targeting SOX TFs are emerging as promising tools for combatting GBM. Combatting GBM has been a demanding and challenging goal for decades. The current therapeutic strategies have not yet provided a cure for GBM and have only resulted in a slight improvement in patient survival. Novel approaches will require the fine adjustment of multimodal therapeutic strategies that simultaneously target numerous hallmarks of cancer cells to win the battle against GBM.", publisher = "Baishideng Publishing Group Inc, Pleasanton", journal = "World Journal of Stem Cells", title = "SOX transcription factors and glioma stem cells: Choosing between stemness and differentiation", pages = "1445-1417", number = "10", volume = "13", doi = "10.4252/wjsc.v13.i10.1417" }
Stevanović, M., Kovačević Grujičić, N., Mojsin, M., Milivojević, M.,& Drakulić, D.. (2021). SOX transcription factors and glioma stem cells: Choosing between stemness and differentiation. in World Journal of Stem Cells Baishideng Publishing Group Inc, Pleasanton., 13(10), 1417-1445. https://doi.org/10.4252/wjsc.v13.i10.1417
Stevanović M, Kovačević Grujičić N, Mojsin M, Milivojević M, Drakulić D. SOX transcription factors and glioma stem cells: Choosing between stemness and differentiation. in World Journal of Stem Cells. 2021;13(10):1417-1445. doi:10.4252/wjsc.v13.i10.1417 .
Stevanović, Milena, Kovačević Grujičić, Nataša, Mojsin, Marija, Milivojević, Milena, Drakulić, Danijela, "SOX transcription factors and glioma stem cells: Choosing between stemness and differentiation" in World Journal of Stem Cells, 13, no. 10 (2021):1417-1445, https://doi.org/10.4252/wjsc.v13.i10.1417 . .