Characterization of human skeletal muscle Ankrd2
Само за регистроване кориснике
2001
Аутори
Pallavicini, AKojić, Snežana
Bean, C
Vainzof, M
Salamon, M
Ievolella, C
Bortoletto, G
Pacchioni, B
Zatz, M
Lanfranchi, G
Faulkner, G
Valle, G
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Human Ankrd2 transcript encodes a 37-kDa protein that is similar to mouse Ankrd2 recently shown to be involved in hypertrophy of skeletal muscle. These novel ankyrin-rich proteins are related to C-193/CARP/MARP, a cardiac protein involved in the control of cardiac hypertrophy. A human genomic region of 14,300 bp was sequenced revealing a gene organization similar to mouse Ankrd2 with nine exons, four of which encode ankyrin repeats. The intracellular localization of Ankrd2 was unknown since no protein studies had been reported. In this paper we studied the intracellular localization of the protein and its expression on differentiation using polyclonal and monoclonal antibodies produced to human Ankrd2. In adult skeletal muscle Ankrd2 is found in slow fibers; however, not all of the slow fibers express Ankrd2 at the same level. This is particularly evident in dystrophic muscles, where the expression of Ankrd2 in slow fibers seems to be severely reduced.
Кључне речи:
signaling pathways / muscle proteins / muscle plasticity / hypertrophy / ankyrinИзвор:
Biochemical and Biophysical Research Communications, 2001, 285, 2, 378-386Издавач:
- Academic Press Inc Elsevier Science, San Diego
Финансирање / пројекти:
- Telethon [1023] Funding Source: Medline
DOI: 10.1006/bbrc.2001.5131
ISSN: 0006-291X
PubMed: 11444853
WoS: 000170020900034
Scopus: 2-s2.0-0034816094
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Pallavicini, A AU - Kojić, Snežana AU - Bean, C AU - Vainzof, M AU - Salamon, M AU - Ievolella, C AU - Bortoletto, G AU - Pacchioni, B AU - Zatz, M AU - Lanfranchi, G AU - Faulkner, G AU - Valle, G PY - 2001 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/148 AB - Human Ankrd2 transcript encodes a 37-kDa protein that is similar to mouse Ankrd2 recently shown to be involved in hypertrophy of skeletal muscle. These novel ankyrin-rich proteins are related to C-193/CARP/MARP, a cardiac protein involved in the control of cardiac hypertrophy. A human genomic region of 14,300 bp was sequenced revealing a gene organization similar to mouse Ankrd2 with nine exons, four of which encode ankyrin repeats. The intracellular localization of Ankrd2 was unknown since no protein studies had been reported. In this paper we studied the intracellular localization of the protein and its expression on differentiation using polyclonal and monoclonal antibodies produced to human Ankrd2. In adult skeletal muscle Ankrd2 is found in slow fibers; however, not all of the slow fibers express Ankrd2 at the same level. This is particularly evident in dystrophic muscles, where the expression of Ankrd2 in slow fibers seems to be severely reduced. PB - Academic Press Inc Elsevier Science, San Diego T2 - Biochemical and Biophysical Research Communications T1 - Characterization of human skeletal muscle Ankrd2 EP - 386 IS - 2 SP - 378 VL - 285 DO - 10.1006/bbrc.2001.5131 ER -
@article{ author = "Pallavicini, A and Kojić, Snežana and Bean, C and Vainzof, M and Salamon, M and Ievolella, C and Bortoletto, G and Pacchioni, B and Zatz, M and Lanfranchi, G and Faulkner, G and Valle, G", year = "2001", abstract = "Human Ankrd2 transcript encodes a 37-kDa protein that is similar to mouse Ankrd2 recently shown to be involved in hypertrophy of skeletal muscle. These novel ankyrin-rich proteins are related to C-193/CARP/MARP, a cardiac protein involved in the control of cardiac hypertrophy. A human genomic region of 14,300 bp was sequenced revealing a gene organization similar to mouse Ankrd2 with nine exons, four of which encode ankyrin repeats. The intracellular localization of Ankrd2 was unknown since no protein studies had been reported. In this paper we studied the intracellular localization of the protein and its expression on differentiation using polyclonal and monoclonal antibodies produced to human Ankrd2. In adult skeletal muscle Ankrd2 is found in slow fibers; however, not all of the slow fibers express Ankrd2 at the same level. This is particularly evident in dystrophic muscles, where the expression of Ankrd2 in slow fibers seems to be severely reduced.", publisher = "Academic Press Inc Elsevier Science, San Diego", journal = "Biochemical and Biophysical Research Communications", title = "Characterization of human skeletal muscle Ankrd2", pages = "386-378", number = "2", volume = "285", doi = "10.1006/bbrc.2001.5131" }
Pallavicini, A., Kojić, S., Bean, C., Vainzof, M., Salamon, M., Ievolella, C., Bortoletto, G., Pacchioni, B., Zatz, M., Lanfranchi, G., Faulkner, G.,& Valle, G.. (2001). Characterization of human skeletal muscle Ankrd2. in Biochemical and Biophysical Research Communications Academic Press Inc Elsevier Science, San Diego., 285(2), 378-386. https://doi.org/10.1006/bbrc.2001.5131
Pallavicini A, Kojić S, Bean C, Vainzof M, Salamon M, Ievolella C, Bortoletto G, Pacchioni B, Zatz M, Lanfranchi G, Faulkner G, Valle G. Characterization of human skeletal muscle Ankrd2. in Biochemical and Biophysical Research Communications. 2001;285(2):378-386. doi:10.1006/bbrc.2001.5131 .
Pallavicini, A, Kojić, Snežana, Bean, C, Vainzof, M, Salamon, M, Ievolella, C, Bortoletto, G, Pacchioni, B, Zatz, M, Lanfranchi, G, Faulkner, G, Valle, G, "Characterization of human skeletal muscle Ankrd2" in Biochemical and Biophysical Research Communications, 285, no. 2 (2001):378-386, https://doi.org/10.1006/bbrc.2001.5131 . .