alpha-Tocopherol Acetate Attenuates Mitochondrial Oxygen Consumption and Maintains Primitive Cells within Mesenchymal Stromal Cell Population
Само за регистроване кориснике
2021
Аутори
Loncarić, DarijaRodriguez, Laura
Debeissat, Christelle
Touya, Nicolas
Labat, Veronique
Villacreces, Arnaud
Bouzier-Sore, Anne-Karine
Pasquet, Jean-Max
de la Grange, Philippe Brunet
Vlaski-Lafarge, Marija
Pavlović, Sonja
Ivanović, Zoran
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
We present here the data showing, in standard cultures exposed to atmospheric O-2 concentration, that alpha-tocopherol acetate (alpha-TOA) has a positive impact on primitive cells inside mesenchymal stromal cell (MstroC) population, by maintaining their proliferative capacity. alpha-TOA decreases the O-2 consumption rate of MStroC probably by impacting respiratory chain complex II activity. This action, however, is not associated with a compensatory increase in glycolysis activity, in spite of the fact that the degradation of HIF-1 alpha was decreased in presence of alpha-TOA. This is in line with a moderate enhancement of mtROS upon alpha-TOA treatment. However, the absence of glycolysis stimulation implies the inactivity of HIF-1 alpha which might - if it were active - be related to the maintenance of stemness. It should be stressed that alpha-TOA might act directly on the gene expression as well as the mtROS themselves, which remains to be elucidated.
Кључне речи:
mtROS / MStroC / MSC / MPC / HIF-1 alpha / Electron transport chain / Alpha-tocopherol acetateИзвор:
Stem Cell Reviews and Reports, 2021, 17, 4, 1390-1405Издавач:
- Springer, New York
Финансирање / пројекти:
- A.E.C. T Euro region Aquitania-Euskadi-Navarra (2019/3) grant "Cardioreg"
- Ретке болести: молекуларна патофизиологија, дијагностички и терапијски модалитети и социјални, етички и правни аспекти (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41004)
Напомена:
- Peer-reviewed manuscript: https://imagine.imgge.bg.ac.rs/handle/123456789/1754
Повезане информације:
- Друга верзија
https://imagine.imgge.bg.ac.rs/handle/123456789/1754 - Друга верзија
https://doi.org/10.1007/s12015-020-10111-9
DOI: 10.1007/s12015-020-10111-9
ISSN: 2629-3269
PubMed: 33511517
WoS: 000612560600001
Scopus: 2-s2.0-85099907001
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Loncarić, Darija AU - Rodriguez, Laura AU - Debeissat, Christelle AU - Touya, Nicolas AU - Labat, Veronique AU - Villacreces, Arnaud AU - Bouzier-Sore, Anne-Karine AU - Pasquet, Jean-Max AU - de la Grange, Philippe Brunet AU - Vlaski-Lafarge, Marija AU - Pavlović, Sonja AU - Ivanović, Zoran PY - 2021 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1491 AB - We present here the data showing, in standard cultures exposed to atmospheric O-2 concentration, that alpha-tocopherol acetate (alpha-TOA) has a positive impact on primitive cells inside mesenchymal stromal cell (MstroC) population, by maintaining their proliferative capacity. alpha-TOA decreases the O-2 consumption rate of MStroC probably by impacting respiratory chain complex II activity. This action, however, is not associated with a compensatory increase in glycolysis activity, in spite of the fact that the degradation of HIF-1 alpha was decreased in presence of alpha-TOA. This is in line with a moderate enhancement of mtROS upon alpha-TOA treatment. However, the absence of glycolysis stimulation implies the inactivity of HIF-1 alpha which might - if it were active - be related to the maintenance of stemness. It should be stressed that alpha-TOA might act directly on the gene expression as well as the mtROS themselves, which remains to be elucidated. PB - Springer, New York T2 - Stem Cell Reviews and Reports T1 - alpha-Tocopherol Acetate Attenuates Mitochondrial Oxygen Consumption and Maintains Primitive Cells within Mesenchymal Stromal Cell Population EP - 1405 IS - 4 SP - 1390 VL - 17 DO - 10.1007/s12015-020-10111-9 ER -
@article{ author = "Loncarić, Darija and Rodriguez, Laura and Debeissat, Christelle and Touya, Nicolas and Labat, Veronique and Villacreces, Arnaud and Bouzier-Sore, Anne-Karine and Pasquet, Jean-Max and de la Grange, Philippe Brunet and Vlaski-Lafarge, Marija and Pavlović, Sonja and Ivanović, Zoran", year = "2021", abstract = "We present here the data showing, in standard cultures exposed to atmospheric O-2 concentration, that alpha-tocopherol acetate (alpha-TOA) has a positive impact on primitive cells inside mesenchymal stromal cell (MstroC) population, by maintaining their proliferative capacity. alpha-TOA decreases the O-2 consumption rate of MStroC probably by impacting respiratory chain complex II activity. This action, however, is not associated with a compensatory increase in glycolysis activity, in spite of the fact that the degradation of HIF-1 alpha was decreased in presence of alpha-TOA. This is in line with a moderate enhancement of mtROS upon alpha-TOA treatment. However, the absence of glycolysis stimulation implies the inactivity of HIF-1 alpha which might - if it were active - be related to the maintenance of stemness. It should be stressed that alpha-TOA might act directly on the gene expression as well as the mtROS themselves, which remains to be elucidated.", publisher = "Springer, New York", journal = "Stem Cell Reviews and Reports", title = "alpha-Tocopherol Acetate Attenuates Mitochondrial Oxygen Consumption and Maintains Primitive Cells within Mesenchymal Stromal Cell Population", pages = "1405-1390", number = "4", volume = "17", doi = "10.1007/s12015-020-10111-9" }
Loncarić, D., Rodriguez, L., Debeissat, C., Touya, N., Labat, V., Villacreces, A., Bouzier-Sore, A., Pasquet, J., de la Grange, P. B., Vlaski-Lafarge, M., Pavlović, S.,& Ivanović, Z.. (2021). alpha-Tocopherol Acetate Attenuates Mitochondrial Oxygen Consumption and Maintains Primitive Cells within Mesenchymal Stromal Cell Population. in Stem Cell Reviews and Reports Springer, New York., 17(4), 1390-1405. https://doi.org/10.1007/s12015-020-10111-9
Loncarić D, Rodriguez L, Debeissat C, Touya N, Labat V, Villacreces A, Bouzier-Sore A, Pasquet J, de la Grange PB, Vlaski-Lafarge M, Pavlović S, Ivanović Z. alpha-Tocopherol Acetate Attenuates Mitochondrial Oxygen Consumption and Maintains Primitive Cells within Mesenchymal Stromal Cell Population. in Stem Cell Reviews and Reports. 2021;17(4):1390-1405. doi:10.1007/s12015-020-10111-9 .
Loncarić, Darija, Rodriguez, Laura, Debeissat, Christelle, Touya, Nicolas, Labat, Veronique, Villacreces, Arnaud, Bouzier-Sore, Anne-Karine, Pasquet, Jean-Max, de la Grange, Philippe Brunet, Vlaski-Lafarge, Marija, Pavlović, Sonja, Ivanović, Zoran, "alpha-Tocopherol Acetate Attenuates Mitochondrial Oxygen Consumption and Maintains Primitive Cells within Mesenchymal Stromal Cell Population" in Stem Cell Reviews and Reports, 17, no. 4 (2021):1390-1405, https://doi.org/10.1007/s12015-020-10111-9 . .