Trends in molecular characteristics and antimicrobial resistance of group B streptococci: a multicenter study in Serbia, 2015-2020
Аутори
Kekić, DusanGajić, Ina
Opavski, Nataša
Kojić, Milan
Vukotić, Goran
Smitran, Aleksandra
Bosković, Lidija
Stojković, Marina
Ranin, Lazar
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Group B Streptococcus (GBS) is a major cause of neonatal morbidity and mortality. Serbia has not fully implemented preventive measures against GBS neonatal diseases. Therefore, we aimed to assess the maternal GBS colonisation and invasive neonatal disease rate, to reveal the trends of antimicrobial resistance and serotype distribution of GBS from various patient groups. Randomly selected non-invasive (n=991) and all invasive GBS (n=80) collected throughout Serbia from 2015 to 2020 were tested for antimicrobial susceptibility, capsular typing, and hvgA detection. Overall, 877/5621 (15.6%) pregnant women were colonised with GBS. Invasive GBS infections incidence in infants (0.18/1000 live births) showed a decreasing trend (0.3 to 0.1/1000 live births). Type III was overrepresented in infants with invasive infections (n=35, 58.3%), whereas type V predominated among colonised adults (n=224, 25.5%) and those with noninvasive (n=37, 32.5%) and invasive infections (n=8, 40%). The hypervirulen...t clone III/ST17 was highly associated with invasive infections (n=28, 35%), particularly late-onset disease (n=9, 47.4%), showing an increase from 12.3 to 14.8%. The GBS resistance to erythromycin and clindamycin was 26.7% and 22.1%, respectively, with an upward trend. The emergence of the hypervirulent clone III/ST17 and the escalation in GBS resistance highlight an urgent need for continuous monitoring of GBS infections.
Извор:
Scientific Reports, 2021, 11, 1Издавач:
- Nature Research, Berlin
Финансирање / пројекти:
- Бактерије резистентне на антибиотике у Србији: фенотипска и генотипска карактеризација (RS-MESTD-Basic Research (BR or ON)-175039)
DOI: 10.1038/s41598-020-79354-3
ISSN: 2045-2322
PubMed: 33436658
WoS: 000621919500003
Scopus: 2-s2.0-85099211490
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Kekić, Dusan AU - Gajić, Ina AU - Opavski, Nataša AU - Kojić, Milan AU - Vukotić, Goran AU - Smitran, Aleksandra AU - Bosković, Lidija AU - Stojković, Marina AU - Ranin, Lazar PY - 2021 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1493 AB - Group B Streptococcus (GBS) is a major cause of neonatal morbidity and mortality. Serbia has not fully implemented preventive measures against GBS neonatal diseases. Therefore, we aimed to assess the maternal GBS colonisation and invasive neonatal disease rate, to reveal the trends of antimicrobial resistance and serotype distribution of GBS from various patient groups. Randomly selected non-invasive (n=991) and all invasive GBS (n=80) collected throughout Serbia from 2015 to 2020 were tested for antimicrobial susceptibility, capsular typing, and hvgA detection. Overall, 877/5621 (15.6%) pregnant women were colonised with GBS. Invasive GBS infections incidence in infants (0.18/1000 live births) showed a decreasing trend (0.3 to 0.1/1000 live births). Type III was overrepresented in infants with invasive infections (n=35, 58.3%), whereas type V predominated among colonised adults (n=224, 25.5%) and those with noninvasive (n=37, 32.5%) and invasive infections (n=8, 40%). The hypervirulent clone III/ST17 was highly associated with invasive infections (n=28, 35%), particularly late-onset disease (n=9, 47.4%), showing an increase from 12.3 to 14.8%. The GBS resistance to erythromycin and clindamycin was 26.7% and 22.1%, respectively, with an upward trend. The emergence of the hypervirulent clone III/ST17 and the escalation in GBS resistance highlight an urgent need for continuous monitoring of GBS infections. PB - Nature Research, Berlin T2 - Scientific Reports T1 - Trends in molecular characteristics and antimicrobial resistance of group B streptococci: a multicenter study in Serbia, 2015-2020 IS - 1 VL - 11 DO - 10.1038/s41598-020-79354-3 ER -
@article{ author = "Kekić, Dusan and Gajić, Ina and Opavski, Nataša and Kojić, Milan and Vukotić, Goran and Smitran, Aleksandra and Bosković, Lidija and Stojković, Marina and Ranin, Lazar", year = "2021", abstract = "Group B Streptococcus (GBS) is a major cause of neonatal morbidity and mortality. Serbia has not fully implemented preventive measures against GBS neonatal diseases. Therefore, we aimed to assess the maternal GBS colonisation and invasive neonatal disease rate, to reveal the trends of antimicrobial resistance and serotype distribution of GBS from various patient groups. Randomly selected non-invasive (n=991) and all invasive GBS (n=80) collected throughout Serbia from 2015 to 2020 were tested for antimicrobial susceptibility, capsular typing, and hvgA detection. Overall, 877/5621 (15.6%) pregnant women were colonised with GBS. Invasive GBS infections incidence in infants (0.18/1000 live births) showed a decreasing trend (0.3 to 0.1/1000 live births). Type III was overrepresented in infants with invasive infections (n=35, 58.3%), whereas type V predominated among colonised adults (n=224, 25.5%) and those with noninvasive (n=37, 32.5%) and invasive infections (n=8, 40%). The hypervirulent clone III/ST17 was highly associated with invasive infections (n=28, 35%), particularly late-onset disease (n=9, 47.4%), showing an increase from 12.3 to 14.8%. The GBS resistance to erythromycin and clindamycin was 26.7% and 22.1%, respectively, with an upward trend. The emergence of the hypervirulent clone III/ST17 and the escalation in GBS resistance highlight an urgent need for continuous monitoring of GBS infections.", publisher = "Nature Research, Berlin", journal = "Scientific Reports", title = "Trends in molecular characteristics and antimicrobial resistance of group B streptococci: a multicenter study in Serbia, 2015-2020", number = "1", volume = "11", doi = "10.1038/s41598-020-79354-3" }
Kekić, D., Gajić, I., Opavski, N., Kojić, M., Vukotić, G., Smitran, A., Bosković, L., Stojković, M.,& Ranin, L.. (2021). Trends in molecular characteristics and antimicrobial resistance of group B streptococci: a multicenter study in Serbia, 2015-2020. in Scientific Reports Nature Research, Berlin., 11(1). https://doi.org/10.1038/s41598-020-79354-3
Kekić D, Gajić I, Opavski N, Kojić M, Vukotić G, Smitran A, Bosković L, Stojković M, Ranin L. Trends in molecular characteristics and antimicrobial resistance of group B streptococci: a multicenter study in Serbia, 2015-2020. in Scientific Reports. 2021;11(1). doi:10.1038/s41598-020-79354-3 .
Kekić, Dusan, Gajić, Ina, Opavski, Nataša, Kojić, Milan, Vukotić, Goran, Smitran, Aleksandra, Bosković, Lidija, Stojković, Marina, Ranin, Lazar, "Trends in molecular characteristics and antimicrobial resistance of group B streptococci: a multicenter study in Serbia, 2015-2020" in Scientific Reports, 11, no. 1 (2021), https://doi.org/10.1038/s41598-020-79354-3 . .