The first insight into the genetic structure of the population of modern Serbia
Аутори
Drljaca, TamaraZukić, Branka
Kovacević, Vladimir
Gemović, Branislava
Klaassen, Kristel
Perović, Vladimir
Lazarević, Mladen
Pavlović, Sonja
Veljković, Nevena
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The complete understanding of the genomic contribution to complex traits, diseases, and response to treatments, as well as genomic medicine application to the well-being of all humans will be achieved through the global variome that encompasses fine-scale genetic diversity. Despite significant efforts in recent years, uneven representation still characterizes genomic resources and among the underrepresented European populations are the Western Balkans including the Serbian population. Our research addresses this gap and presents the first ever targeted sequencing dataset of variants in clinically relevant genes. By measuring population differentiation and applying the Principal Component and Admixture analysis we demonstrated that the Serbian population differs little from other European populations, yet we identified several novel and more frequent variants that appear as its unique genetic determinants. We explored thoroughly the functional impact of frequent variants and its correla...tion with the health burden of the population of Serbia based on a sample of 144 individuals. Our variants catalogue improves the understanding of genetics of modern Serbia, contributes to research on ancestry, and aids in improvements of well-being and health equity. In addition, this resource may also be applicable in neighboring regions and valuable in worldwide functional analyses of genetic variants in individuals of European descent.
Извор:
Scientific Reports, 2021, 11, 1Издавач:
- Nature Portfolio, Berlin
Финансирање / пројекти:
- Ministry of Education, Science and Technological Development, Republic of Serbia
DOI: 10.1038/s41598-021-93129-4
ISSN: 2045-2322
PubMed: 34234178
WoS: 000674547300003
Scopus: 2-s2.0-85109419642
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Drljaca, Tamara AU - Zukić, Branka AU - Kovacević, Vladimir AU - Gemović, Branislava AU - Klaassen, Kristel AU - Perović, Vladimir AU - Lazarević, Mladen AU - Pavlović, Sonja AU - Veljković, Nevena PY - 2021 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1502 AB - The complete understanding of the genomic contribution to complex traits, diseases, and response to treatments, as well as genomic medicine application to the well-being of all humans will be achieved through the global variome that encompasses fine-scale genetic diversity. Despite significant efforts in recent years, uneven representation still characterizes genomic resources and among the underrepresented European populations are the Western Balkans including the Serbian population. Our research addresses this gap and presents the first ever targeted sequencing dataset of variants in clinically relevant genes. By measuring population differentiation and applying the Principal Component and Admixture analysis we demonstrated that the Serbian population differs little from other European populations, yet we identified several novel and more frequent variants that appear as its unique genetic determinants. We explored thoroughly the functional impact of frequent variants and its correlation with the health burden of the population of Serbia based on a sample of 144 individuals. Our variants catalogue improves the understanding of genetics of modern Serbia, contributes to research on ancestry, and aids in improvements of well-being and health equity. In addition, this resource may also be applicable in neighboring regions and valuable in worldwide functional analyses of genetic variants in individuals of European descent. PB - Nature Portfolio, Berlin T2 - Scientific Reports T1 - The first insight into the genetic structure of the population of modern Serbia IS - 1 VL - 11 DO - 10.1038/s41598-021-93129-4 ER -
@article{ author = "Drljaca, Tamara and Zukić, Branka and Kovacević, Vladimir and Gemović, Branislava and Klaassen, Kristel and Perović, Vladimir and Lazarević, Mladen and Pavlović, Sonja and Veljković, Nevena", year = "2021", abstract = "The complete understanding of the genomic contribution to complex traits, diseases, and response to treatments, as well as genomic medicine application to the well-being of all humans will be achieved through the global variome that encompasses fine-scale genetic diversity. Despite significant efforts in recent years, uneven representation still characterizes genomic resources and among the underrepresented European populations are the Western Balkans including the Serbian population. Our research addresses this gap and presents the first ever targeted sequencing dataset of variants in clinically relevant genes. By measuring population differentiation and applying the Principal Component and Admixture analysis we demonstrated that the Serbian population differs little from other European populations, yet we identified several novel and more frequent variants that appear as its unique genetic determinants. We explored thoroughly the functional impact of frequent variants and its correlation with the health burden of the population of Serbia based on a sample of 144 individuals. Our variants catalogue improves the understanding of genetics of modern Serbia, contributes to research on ancestry, and aids in improvements of well-being and health equity. In addition, this resource may also be applicable in neighboring regions and valuable in worldwide functional analyses of genetic variants in individuals of European descent.", publisher = "Nature Portfolio, Berlin", journal = "Scientific Reports", title = "The first insight into the genetic structure of the population of modern Serbia", number = "1", volume = "11", doi = "10.1038/s41598-021-93129-4" }
Drljaca, T., Zukić, B., Kovacević, V., Gemović, B., Klaassen, K., Perović, V., Lazarević, M., Pavlović, S.,& Veljković, N.. (2021). The first insight into the genetic structure of the population of modern Serbia. in Scientific Reports Nature Portfolio, Berlin., 11(1). https://doi.org/10.1038/s41598-021-93129-4
Drljaca T, Zukić B, Kovacević V, Gemović B, Klaassen K, Perović V, Lazarević M, Pavlović S, Veljković N. The first insight into the genetic structure of the population of modern Serbia. in Scientific Reports. 2021;11(1). doi:10.1038/s41598-021-93129-4 .
Drljaca, Tamara, Zukić, Branka, Kovacević, Vladimir, Gemović, Branislava, Klaassen, Kristel, Perović, Vladimir, Lazarević, Mladen, Pavlović, Sonja, Veljković, Nevena, "The first insight into the genetic structure of the population of modern Serbia" in Scientific Reports, 11, no. 1 (2021), https://doi.org/10.1038/s41598-021-93129-4 . .