Interplay of SOX transcription factors and microRNAs in the brain under physiological and pathological conditions
Authors
Stevanović, MilenaStanisavljević Ninković, Danijela
Mojsin, Marija
Drakulić, Danijela
Schwirtlich, Marija
Article (Published version)
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Precise tuning of gene expression, accomplished by regulatory networks of transcription factors, epigenetic modifiers, and microRNAs, is crucial for the proper neural development and function of the brain cells. The SOX transcription factors are involved in regulating diverse cellular processes during embryonic and adult neurogenesis, such as maintaining the cell stemness, cell proliferation, cell fate decisions, and terminal differentiation into neurons and glial cells. MicroRNAs represent a class of small non-coding RNAs that play important roles in the regulation of gene expression. Together with other gene regulatory factors, microRNAs regulate different processes during neurogenesis and orchestrate the spatial and temporal expression important for neurodevelopment. The emerging data point to a complex regulatory network between SOX transcription factors and microRNAs that govern distinct cellular activities in the developing and adult brain. Deregulated SOX/microRNA interplay in s...ignaling pathways that influence the homeostasis and plasticity in the brain has been revealed in various brain pathologies, including neurodegenerative disorders, traumatic brain injury, and cancer. Therapeutic strategies that target SOX/microRNA interplay have emerged in recent years as a promising tool to target neural tissue regeneration and enhance neurorestoration. Numerous studies have confirmed complex interactions between microRNAs and SOX-specific mRNAs regulating key features of glioblastoma. Keeping in mind the crucial roles of SOX genes and microRNAs in neural development, we focus this review on SOX/microRNAs interplay in the brain during development and adulthood in physiological and pathological conditions. Special focus was made on their interplay in brain pathologies to summarize current knowledge and highlight potential future development of molecular therapies.
Keywords:
traumatic brain injury / SOX/miRNA interplay / neurogenesis / neurodevelopment / neurodegenerative diseases / neural tissue regeneration / neural stem cells / ischemic stroke / glioma stem cells / gliogenesis / glioblastoma / dysregulation of miRNA expressionSource:
Neural Regeneration Research, 2022, 17, 11, 2325-2334Publisher:
- Wolters Kluwer Medknow Publications, Mumbai
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200042 (University of Belgrade, Institute of Molecular Genetics and Genetic Engineering) (RS-MESTD-inst-2020-200042)
- Serbian Academy of Sciences and Arts [F24]
DOI: 10.4103/1673-5374.338990
ISSN: 1673-5374
WoS: 000866351500019
Scopus: 2-s2.0-85129856998
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Stevanović, Milena AU - Stanisavljević Ninković, Danijela AU - Mojsin, Marija AU - Drakulić, Danijela AU - Schwirtlich, Marija PY - 2022 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1548 AB - Precise tuning of gene expression, accomplished by regulatory networks of transcription factors, epigenetic modifiers, and microRNAs, is crucial for the proper neural development and function of the brain cells. The SOX transcription factors are involved in regulating diverse cellular processes during embryonic and adult neurogenesis, such as maintaining the cell stemness, cell proliferation, cell fate decisions, and terminal differentiation into neurons and glial cells. MicroRNAs represent a class of small non-coding RNAs that play important roles in the regulation of gene expression. Together with other gene regulatory factors, microRNAs regulate different processes during neurogenesis and orchestrate the spatial and temporal expression important for neurodevelopment. The emerging data point to a complex regulatory network between SOX transcription factors and microRNAs that govern distinct cellular activities in the developing and adult brain. Deregulated SOX/microRNA interplay in signaling pathways that influence the homeostasis and plasticity in the brain has been revealed in various brain pathologies, including neurodegenerative disorders, traumatic brain injury, and cancer. Therapeutic strategies that target SOX/microRNA interplay have emerged in recent years as a promising tool to target neural tissue regeneration and enhance neurorestoration. Numerous studies have confirmed complex interactions between microRNAs and SOX-specific mRNAs regulating key features of glioblastoma. Keeping in mind the crucial roles of SOX genes and microRNAs in neural development, we focus this review on SOX/microRNAs interplay in the brain during development and adulthood in physiological and pathological conditions. Special focus was made on their interplay in brain pathologies to summarize current knowledge and highlight potential future development of molecular therapies. PB - Wolters Kluwer Medknow Publications, Mumbai T2 - Neural Regeneration Research T1 - Interplay of SOX transcription factors and microRNAs in the brain under physiological and pathological conditions EP - 2334 IS - 11 SP - 2325 VL - 17 DO - 10.4103/1673-5374.338990 ER -
@article{ author = "Stevanović, Milena and Stanisavljević Ninković, Danijela and Mojsin, Marija and Drakulić, Danijela and Schwirtlich, Marija", year = "2022", abstract = "Precise tuning of gene expression, accomplished by regulatory networks of transcription factors, epigenetic modifiers, and microRNAs, is crucial for the proper neural development and function of the brain cells. The SOX transcription factors are involved in regulating diverse cellular processes during embryonic and adult neurogenesis, such as maintaining the cell stemness, cell proliferation, cell fate decisions, and terminal differentiation into neurons and glial cells. MicroRNAs represent a class of small non-coding RNAs that play important roles in the regulation of gene expression. Together with other gene regulatory factors, microRNAs regulate different processes during neurogenesis and orchestrate the spatial and temporal expression important for neurodevelopment. The emerging data point to a complex regulatory network between SOX transcription factors and microRNAs that govern distinct cellular activities in the developing and adult brain. Deregulated SOX/microRNA interplay in signaling pathways that influence the homeostasis and plasticity in the brain has been revealed in various brain pathologies, including neurodegenerative disorders, traumatic brain injury, and cancer. Therapeutic strategies that target SOX/microRNA interplay have emerged in recent years as a promising tool to target neural tissue regeneration and enhance neurorestoration. Numerous studies have confirmed complex interactions between microRNAs and SOX-specific mRNAs regulating key features of glioblastoma. Keeping in mind the crucial roles of SOX genes and microRNAs in neural development, we focus this review on SOX/microRNAs interplay in the brain during development and adulthood in physiological and pathological conditions. Special focus was made on their interplay in brain pathologies to summarize current knowledge and highlight potential future development of molecular therapies.", publisher = "Wolters Kluwer Medknow Publications, Mumbai", journal = "Neural Regeneration Research", title = "Interplay of SOX transcription factors and microRNAs in the brain under physiological and pathological conditions", pages = "2334-2325", number = "11", volume = "17", doi = "10.4103/1673-5374.338990" }
Stevanović, M., Stanisavljević Ninković, D., Mojsin, M., Drakulić, D.,& Schwirtlich, M.. (2022). Interplay of SOX transcription factors and microRNAs in the brain under physiological and pathological conditions. in Neural Regeneration Research Wolters Kluwer Medknow Publications, Mumbai., 17(11), 2325-2334. https://doi.org/10.4103/1673-5374.338990
Stevanović M, Stanisavljević Ninković D, Mojsin M, Drakulić D, Schwirtlich M. Interplay of SOX transcription factors and microRNAs in the brain under physiological and pathological conditions. in Neural Regeneration Research. 2022;17(11):2325-2334. doi:10.4103/1673-5374.338990 .
Stevanović, Milena, Stanisavljević Ninković, Danijela, Mojsin, Marija, Drakulić, Danijela, Schwirtlich, Marija, "Interplay of SOX transcription factors and microRNAs in the brain under physiological and pathological conditions" in Neural Regeneration Research, 17, no. 11 (2022):2325-2334, https://doi.org/10.4103/1673-5374.338990 . .