Coumarin-Palladium(II) Complex Acts as a Potent and Non-Toxic Anticancer Agent against Pancreatic Carcinoma Cells
2022
Аутори
Krstić, AleksandraPavić, Aleksandar
Avdović, Edina H.
Marković, Zoran
Stevanović, Milena
Petrović, Isidora
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Pancreatic carcinoma still represents one of the most lethal malignant diseases in the world although some progress has been made in treating the disease in the past decades. Current multi-agent treatment options have improved the overall survival of patients, however, more effective treatment strategies are still needed. In this paper we have characterized the anticancer potential of coumarin-palladium(II) complex against pancreatic carcinoma cells. Cells viability, colony formation and migratory potential of pancreatic carcinoma cells were assessed in vitro, followed by evaluation of apoptosis induction and in vivo testing on zebrafish. Presented results showed remarkable reduction in pancreatic carcinoma cells growth both in vitro and in vivo, being effective at micromolar concentrations (0.5 mu M). Treatments induced apoptosis, increased BAX/BCL-2 ratio and suppressed the expression of SOX9 and SOX18, genes shown to be significantly up-regulated in pancreatic ductal adenocarcinoma.... Importantly, treatments of the zebrafish-pancreatic adenocarcinoma xenografts resulted in significant reduction in tumor mass, without provoking any adverse toxic effects including hepatotoxicity. Presented results indicate the great potential of the tested compound and the perspective of its further development towards pancreatic cancer therapy.
Кључне речи:
pancreatic carcinoma / coumarin palladium(II) complex / coumarin derivatives / anticancerИзвор:
Molecules, 2022, 27, 7Издавач:
- MDPI, Basel
Финансирање / пројекти:
- Serbian Academy of Sciences and Arts [F24]
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200042 (Универзитет у Београду, Институт за молекуларну генетику и генетичко инжењерство) (RS-MESTD-inst-2020-200042)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200378 (Институт за информационе технологије, Крагујевац) (RS-MESTD-inst-2020-200378)
DOI: 10.3390/molecules27072115
ISSN: 1420-3049
WoS: 000781117700001
Scopus: 2-s2.0-85127501162
Колекције
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Krstić, Aleksandra AU - Pavić, Aleksandar AU - Avdović, Edina H. AU - Marković, Zoran AU - Stevanović, Milena AU - Petrović, Isidora PY - 2022 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1559 AB - Pancreatic carcinoma still represents one of the most lethal malignant diseases in the world although some progress has been made in treating the disease in the past decades. Current multi-agent treatment options have improved the overall survival of patients, however, more effective treatment strategies are still needed. In this paper we have characterized the anticancer potential of coumarin-palladium(II) complex against pancreatic carcinoma cells. Cells viability, colony formation and migratory potential of pancreatic carcinoma cells were assessed in vitro, followed by evaluation of apoptosis induction and in vivo testing on zebrafish. Presented results showed remarkable reduction in pancreatic carcinoma cells growth both in vitro and in vivo, being effective at micromolar concentrations (0.5 mu M). Treatments induced apoptosis, increased BAX/BCL-2 ratio and suppressed the expression of SOX9 and SOX18, genes shown to be significantly up-regulated in pancreatic ductal adenocarcinoma. Importantly, treatments of the zebrafish-pancreatic adenocarcinoma xenografts resulted in significant reduction in tumor mass, without provoking any adverse toxic effects including hepatotoxicity. Presented results indicate the great potential of the tested compound and the perspective of its further development towards pancreatic cancer therapy. PB - MDPI, Basel T2 - Molecules T1 - Coumarin-Palladium(II) Complex Acts as a Potent and Non-Toxic Anticancer Agent against Pancreatic Carcinoma Cells IS - 7 VL - 27 DO - 10.3390/molecules27072115 ER -
@article{ author = "Krstić, Aleksandra and Pavić, Aleksandar and Avdović, Edina H. and Marković, Zoran and Stevanović, Milena and Petrović, Isidora", year = "2022", abstract = "Pancreatic carcinoma still represents one of the most lethal malignant diseases in the world although some progress has been made in treating the disease in the past decades. Current multi-agent treatment options have improved the overall survival of patients, however, more effective treatment strategies are still needed. In this paper we have characterized the anticancer potential of coumarin-palladium(II) complex against pancreatic carcinoma cells. Cells viability, colony formation and migratory potential of pancreatic carcinoma cells were assessed in vitro, followed by evaluation of apoptosis induction and in vivo testing on zebrafish. Presented results showed remarkable reduction in pancreatic carcinoma cells growth both in vitro and in vivo, being effective at micromolar concentrations (0.5 mu M). Treatments induced apoptosis, increased BAX/BCL-2 ratio and suppressed the expression of SOX9 and SOX18, genes shown to be significantly up-regulated in pancreatic ductal adenocarcinoma. Importantly, treatments of the zebrafish-pancreatic adenocarcinoma xenografts resulted in significant reduction in tumor mass, without provoking any adverse toxic effects including hepatotoxicity. Presented results indicate the great potential of the tested compound and the perspective of its further development towards pancreatic cancer therapy.", publisher = "MDPI, Basel", journal = "Molecules", title = "Coumarin-Palladium(II) Complex Acts as a Potent and Non-Toxic Anticancer Agent against Pancreatic Carcinoma Cells", number = "7", volume = "27", doi = "10.3390/molecules27072115" }
Krstić, A., Pavić, A., Avdović, E. H., Marković, Z., Stevanović, M.,& Petrović, I.. (2022). Coumarin-Palladium(II) Complex Acts as a Potent and Non-Toxic Anticancer Agent against Pancreatic Carcinoma Cells. in Molecules MDPI, Basel., 27(7). https://doi.org/10.3390/molecules27072115
Krstić A, Pavić A, Avdović EH, Marković Z, Stevanović M, Petrović I. Coumarin-Palladium(II) Complex Acts as a Potent and Non-Toxic Anticancer Agent against Pancreatic Carcinoma Cells. in Molecules. 2022;27(7). doi:10.3390/molecules27072115 .
Krstić, Aleksandra, Pavić, Aleksandar, Avdović, Edina H., Marković, Zoran, Stevanović, Milena, Petrović, Isidora, "Coumarin-Palladium(II) Complex Acts as a Potent and Non-Toxic Anticancer Agent against Pancreatic Carcinoma Cells" in Molecules, 27, no. 7 (2022), https://doi.org/10.3390/molecules27072115 . .