Reactive and Senescent Astroglial Phenotypes as Hallmarks of Brain Pathologies
Authors
Lazić, AndrijanaBalint, Vanda
Stanisavljević Ninković, Danijela
Perić, Mina
Stevanović, Milena
Article (Published version)
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Astrocytes, as the most abundant glial cells in the central nervous system, are tightly integrated into neural networks and participate in numerous aspects of brain physiology and pathology. They are the main homeostatic cells in the central nervous system, and the loss of astrocyte physiological functions and/or gain of pro-inflammatory functions, due to their reactivation or cellular senescence, can have profound impacts on the surrounding microenvironment with pathological outcomes. Although the importance of astrocytes is generally recognized, and both senescence and reactive astrogliosis have been extensively reviewed independently, there are only a few comparative overviews of these complex processes. In this review, we summarize the latest data regarding astrocyte reactivation and senescence, and outline similarities and differences between these phenotypes from morphological, functional, and molecular points of view. A special focus has been given to neurodegenerative diseases,... where these phenotypic alternations of astrocytes are significantly implicated. We also summarize current perspectives regarding new advances in model systems based on astrocytes as well as data pointing to these glial cells as potential therapeutic targets.
Keywords:
senescence / SASP / reactive astrogliosis / neurodegenerative diseases / in vitro models / astrocyte-targeted therapy / astrocytesSource:
International Journal of Molecular Sciences, 2022, 23, 9Publisher:
- MDPI, Basel
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200042 (University of Belgrade, Institute of Molecular Genetics and Genetic Engineering) (RS-MESTD-inst-2020-200042)
- Serbian Academy of Sciences and Arts [01-2021]
DOI: 10.3390/ijms23094995
ISSN: 1422-0067
PubMed: 35563385
WoS: 000800720900001
Scopus: 2-s2.0-85129204665
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Lazić, Andrijana AU - Balint, Vanda AU - Stanisavljević Ninković, Danijela AU - Perić, Mina AU - Stevanović, Milena PY - 2022 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1602 AB - Astrocytes, as the most abundant glial cells in the central nervous system, are tightly integrated into neural networks and participate in numerous aspects of brain physiology and pathology. They are the main homeostatic cells in the central nervous system, and the loss of astrocyte physiological functions and/or gain of pro-inflammatory functions, due to their reactivation or cellular senescence, can have profound impacts on the surrounding microenvironment with pathological outcomes. Although the importance of astrocytes is generally recognized, and both senescence and reactive astrogliosis have been extensively reviewed independently, there are only a few comparative overviews of these complex processes. In this review, we summarize the latest data regarding astrocyte reactivation and senescence, and outline similarities and differences between these phenotypes from morphological, functional, and molecular points of view. A special focus has been given to neurodegenerative diseases, where these phenotypic alternations of astrocytes are significantly implicated. We also summarize current perspectives regarding new advances in model systems based on astrocytes as well as data pointing to these glial cells as potential therapeutic targets. PB - MDPI, Basel T2 - International Journal of Molecular Sciences T1 - Reactive and Senescent Astroglial Phenotypes as Hallmarks of Brain Pathologies IS - 9 VL - 23 DO - 10.3390/ijms23094995 ER -
@article{ author = "Lazić, Andrijana and Balint, Vanda and Stanisavljević Ninković, Danijela and Perić, Mina and Stevanović, Milena", year = "2022", abstract = "Astrocytes, as the most abundant glial cells in the central nervous system, are tightly integrated into neural networks and participate in numerous aspects of brain physiology and pathology. They are the main homeostatic cells in the central nervous system, and the loss of astrocyte physiological functions and/or gain of pro-inflammatory functions, due to their reactivation or cellular senescence, can have profound impacts on the surrounding microenvironment with pathological outcomes. Although the importance of astrocytes is generally recognized, and both senescence and reactive astrogliosis have been extensively reviewed independently, there are only a few comparative overviews of these complex processes. In this review, we summarize the latest data regarding astrocyte reactivation and senescence, and outline similarities and differences between these phenotypes from morphological, functional, and molecular points of view. A special focus has been given to neurodegenerative diseases, where these phenotypic alternations of astrocytes are significantly implicated. We also summarize current perspectives regarding new advances in model systems based on astrocytes as well as data pointing to these glial cells as potential therapeutic targets.", publisher = "MDPI, Basel", journal = "International Journal of Molecular Sciences", title = "Reactive and Senescent Astroglial Phenotypes as Hallmarks of Brain Pathologies", number = "9", volume = "23", doi = "10.3390/ijms23094995" }
Lazić, A., Balint, V., Stanisavljević Ninković, D., Perić, M.,& Stevanović, M.. (2022). Reactive and Senescent Astroglial Phenotypes as Hallmarks of Brain Pathologies. in International Journal of Molecular Sciences MDPI, Basel., 23(9). https://doi.org/10.3390/ijms23094995
Lazić A, Balint V, Stanisavljević Ninković D, Perić M, Stevanović M. Reactive and Senescent Astroglial Phenotypes as Hallmarks of Brain Pathologies. in International Journal of Molecular Sciences. 2022;23(9). doi:10.3390/ijms23094995 .
Lazić, Andrijana, Balint, Vanda, Stanisavljević Ninković, Danijela, Perić, Mina, Stevanović, Milena, "Reactive and Senescent Astroglial Phenotypes as Hallmarks of Brain Pathologies" in International Journal of Molecular Sciences, 23, no. 9 (2022), https://doi.org/10.3390/ijms23094995 . .