Приказ основних података о документу
Brh2 and Rad51 promote telomere maintenance in Ustilago maydis, a new model system of DNA repair proteins at telomeres
dc.creator | Yu, Eun Young | |
dc.creator | Kojić, Milorad | |
dc.creator | Holloman, William K. | |
dc.creator | Lue, Neal F. | |
dc.date.accessioned | 2022-12-14T10:35:44Z | |
dc.date.available | 2014-06-01 | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1568-7864 | |
dc.identifier.uri | https://imagine.imgge.bg.ac.rs/handle/123456789/1622 | |
dc.description.abstract | Recent studies implicate a number of DNA repair proteins in mammalian telomere maintenance. However, because several key repair proteins in mammals are missing from the well-studied budding and fission yeast, their roles at telomeres cannot be modeled in standard fungi. In this report, we explored the dimorphic fungus Ustilago maydis as an alternative model for telomere research. This fungus, which belongs to the phylum Basidiomycota, has a telomere repeat unit that is identical to the mammalian repeat, as well as a constellation of DNA repair proteins that more closely mimic the mammalian collection. We showed that the two core components of homology-directed repair (HDR) in U. maydis, namely Brh2 and Rad51, both promote telomere maintenance in telomerase positive cells, just like in mammals. In addition, we found that Brh2 is localized to telomeres in vivo, suggesting that it acts directly at chromosome ends. We surveyed a series of mutants with DNA repair defects, and found many of them to have short telomeres. Our results indicate that factors involved in DNA repair are probably also needed for optimal telomere maintenance in U. maydis, and that this fungus is a useful alternative model system for telomere research. | en |
dc.publisher | Amsterdam : Elsevier Science Bv | |
dc.relation | Pilot Project Grant from the Weill Cornell Cancer Center | |
dc.relation | NIH [GM042482] | |
dc.relation | NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM062631, R01GM042482] Funding Source: NIH RePORTER | |
dc.relation.isversionof | https://imagine.imgge.bg.ac.rs/handle/123456789/653 | |
dc.relation.isversionof | https://doi.org/10.1016/j.dnarep.2013.04.027 | |
dc.rights | embargoedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | DNA Repair | |
dc.subject | Ustilago maydis | en |
dc.subject | Telomere | en |
dc.subject | Rad51 | en |
dc.subject | Homology-directed repair | en |
dc.subject | Brh2 | en |
dc.title | Brh2 and Rad51 promote telomere maintenance in Ustilago maydis, a new model system of DNA repair proteins at telomeres | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dc.citation.epage | 479 | |
dc.citation.issue | 7 | |
dc.citation.other | 12(7): 472-479 | |
dc.citation.rank | M21 | |
dc.citation.spage | 472 | |
dc.citation.volume | 12 | |
dc.description.other | This is the peer reviewed version of the paper: Yu, E. Y., Kojic, M., Holloman, W. K., & Lue, N. F. (2013). Brh2 and Rad51 promote telomere maintenance in Ustilago maydis, a new model system of DNA repair proteins at telomeres. DNA Repair, 12(7), 472–479.[ https://doi.org/10.1016/j.dnarep.2013.04.027] | |
dc.description.other | Published version: [https://imagine.imgge.bg.ac.rs/handle/123456789/653] | |
dc.identifier.doi | 10.1016/j.dnarep.2013.04.027 | |
dc.identifier.fulltext | https://imagine.imgge.bg.ac.rs/bitstream/id/13222/Peer_reviewed_version_Brh2_and_Rad51_promote_telomere_maintenance_in_Ustilago_maydis_a_new_model_system_of_DNA_repair_proteins_at_telomeres_2013.pdf | |
dc.identifier.pmid | 23726221 | |
dc.identifier.scopus | 2-s2.0-84878648069 | |
dc.identifier.wos | 000321417300003 | |
dc.type.version | acceptedVersion |