Polynuclear Silver(I) Complex with Thianthrene: Structural Characterization, Antimicrobial Activity and Interaction with Biomolecules
Аутори
Ašanin, Darko P.Andrejević, Tina P.
Škaro Bogojević, Sanja
Stevanović, Nevena Lj
Aleksic, Ivana
Milivojević, Dušan
Perdih, Franc
Turel, Iztok
Djuran, Miloš I.
Glišić, Biljana
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
New silver(I) complex with thianthrene (tia), [Ag(NO3)(tia)(H2O)]n, was synthesized by the reaction of AgNO3 with an equimolar amount of tia in ethanol/dichloromethane (v/v 1:1) at room temperature, and characterized by NMR, IR and UV-Vis spectroscopy and single-crystal X-ray diffraction analysis. The antimicrobial activity of the synthesized complex was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and Candida spp. This complex showed significant activity toward important human pathogens Gram-positive Staphylococcus aureus and Candida parapsilosis with minimal inhibitory concentrations (MICs) being 3.91 µg/mL. The interaction of [Ag(NO3)(tia)(H2O)]n with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied to evaluate the binding affinity towards these biomolecules for possible insights on the mode of antimicrobial activity. The binding affinity of the investigated complex to BSA is higher than that for DNA, indicating that proteins could... be more favorable binding sites for this complex in comparison to the nucleic acids.
Кључне речи:
antimicrobial activity / DNA/BSA interaction / silver(I) complexes / thianthreneИзвор:
The 1st International Electronic Conference on Applied Sciences, 2020, 67, 1, 4-Издавач:
- MDPI : Basel,Switzerland
Финансирање / пројекти:
- Slovenian Research Agency (grant number P1-0175)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200042 (Универзитет у Београду, Институт за молекуларну генетику и генетичко инжењерство) (RS-MESTD-inst-2020-200042)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200122 (Универзитет у Крагујевцу, Природно-математички факултет) (RS-MESTD-inst-2020-200122)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200378 (Институт за информационе технологије, Крагујевац) (RS-MESTD-inst-2020-200378)
Повезане информације:
- Друга верзија
https://www.mdpi.com/2504-3900/67/1/4 - Друга верзија
https://doi.org/10.3390/ASEC2020-07534 - Друга верзија
https://sciforum.net/paper/view/7534
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - CONF AU - Ašanin, Darko P. AU - Andrejević, Tina P. AU - Škaro Bogojević, Sanja AU - Stevanović, Nevena Lj AU - Aleksic, Ivana AU - Milivojević, Dušan AU - Perdih, Franc AU - Turel, Iztok AU - Djuran, Miloš I. AU - Glišić, Biljana PY - 2020 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1632 AB - New silver(I) complex with thianthrene (tia), [Ag(NO3)(tia)(H2O)]n, was synthesized by the reaction of AgNO3 with an equimolar amount of tia in ethanol/dichloromethane (v/v 1:1) at room temperature, and characterized by NMR, IR and UV-Vis spectroscopy and single-crystal X-ray diffraction analysis. The antimicrobial activity of the synthesized complex was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and Candida spp. This complex showed significant activity toward important human pathogens Gram-positive Staphylococcus aureus and Candida parapsilosis with minimal inhibitory concentrations (MICs) being 3.91 µg/mL. The interaction of [Ag(NO3)(tia)(H2O)]n with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied to evaluate the binding affinity towards these biomolecules for possible insights on the mode of antimicrobial activity. The binding affinity of the investigated complex to BSA is higher than that for DNA, indicating that proteins could be more favorable binding sites for this complex in comparison to the nucleic acids. PB - MDPI : Basel,Switzerland C3 - The 1st International Electronic Conference on Applied Sciences T1 - Polynuclear Silver(I) Complex with Thianthrene: Structural Characterization, Antimicrobial Activity and Interaction with Biomolecules IS - 1 SP - 4 VL - 67 DO - 10.3390/ASEC2020-07534 ER -
@conference{ author = "Ašanin, Darko P. and Andrejević, Tina P. and Škaro Bogojević, Sanja and Stevanović, Nevena Lj and Aleksic, Ivana and Milivojević, Dušan and Perdih, Franc and Turel, Iztok and Djuran, Miloš I. and Glišić, Biljana", year = "2020", abstract = "New silver(I) complex with thianthrene (tia), [Ag(NO3)(tia)(H2O)]n, was synthesized by the reaction of AgNO3 with an equimolar amount of tia in ethanol/dichloromethane (v/v 1:1) at room temperature, and characterized by NMR, IR and UV-Vis spectroscopy and single-crystal X-ray diffraction analysis. The antimicrobial activity of the synthesized complex was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and Candida spp. This complex showed significant activity toward important human pathogens Gram-positive Staphylococcus aureus and Candida parapsilosis with minimal inhibitory concentrations (MICs) being 3.91 µg/mL. The interaction of [Ag(NO3)(tia)(H2O)]n with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied to evaluate the binding affinity towards these biomolecules for possible insights on the mode of antimicrobial activity. The binding affinity of the investigated complex to BSA is higher than that for DNA, indicating that proteins could be more favorable binding sites for this complex in comparison to the nucleic acids.", publisher = "MDPI : Basel,Switzerland", journal = "The 1st International Electronic Conference on Applied Sciences", title = "Polynuclear Silver(I) Complex with Thianthrene: Structural Characterization, Antimicrobial Activity and Interaction with Biomolecules", number = "1", pages = "4", volume = "67", doi = "10.3390/ASEC2020-07534" }
Ašanin, D. P., Andrejević, T. P., Škaro Bogojević, S., Stevanović, N. L., Aleksic, I., Milivojević, D., Perdih, F., Turel, I., Djuran, M. I.,& Glišić, B.. (2020). Polynuclear Silver(I) Complex with Thianthrene: Structural Characterization, Antimicrobial Activity and Interaction with Biomolecules. in The 1st International Electronic Conference on Applied Sciences MDPI : Basel,Switzerland., 67(1), 4. https://doi.org/10.3390/ASEC2020-07534
Ašanin DP, Andrejević TP, Škaro Bogojević S, Stevanović NL, Aleksic I, Milivojević D, Perdih F, Turel I, Djuran MI, Glišić B. Polynuclear Silver(I) Complex with Thianthrene: Structural Characterization, Antimicrobial Activity and Interaction with Biomolecules. in The 1st International Electronic Conference on Applied Sciences. 2020;67(1):4. doi:10.3390/ASEC2020-07534 .
Ašanin, Darko P., Andrejević, Tina P., Škaro Bogojević, Sanja, Stevanović, Nevena Lj, Aleksic, Ivana, Milivojević, Dušan, Perdih, Franc, Turel, Iztok, Djuran, Miloš I., Glišić, Biljana, "Polynuclear Silver(I) Complex with Thianthrene: Structural Characterization, Antimicrobial Activity and Interaction with Biomolecules" in The 1st International Electronic Conference on Applied Sciences, 67, no. 1 (2020):4, https://doi.org/10.3390/ASEC2020-07534 . .