Chapter 8 - Human genetic diversity in health and disease
Само за регистроване кориснике
2020
Поглавље у монографији (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Estimated human genetic diversity is 0.1%, meaning that any two individuals differ at approximately one in every thousand base pairs. A small proportion of these genetic variants have functional consequences affecting health, including susceptibility to infections, diseases, and response to different drugs. Advancements in high-throughput sequencing technology have provided more insight into human genetic makeup and enabled better understanding of the link between genetic variations and health outcomes. However, despite considerable progress in human genetics, there are still many diseases that, given their complexity, cannot be explained simply by the genetic variants present and the involvement of factors such as epigenetics, environmental factors, and gene–environment interactions must be considered. We will discuss how human genetic diversity helps us to uncover the underlining mechanisms in monogenic, complex, and infectious diseases leading to a personalized approach to drug deve...lopment and treatment.
Кључне речи:
biomedicine / complex diseases / epigenetics / Human genetic diversity / infectious diseases / monogenic diseases / personalized medicineИзвор:
Biodiversity and Biomedicine, 2020, 123-136Издавач:
- Academic Press
Повезане информације:
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - CHAP AU - Divac Rankov, Aleksandra AU - Ljujić, Mila PY - 2020 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1637 AB - Estimated human genetic diversity is 0.1%, meaning that any two individuals differ at approximately one in every thousand base pairs. A small proportion of these genetic variants have functional consequences affecting health, including susceptibility to infections, diseases, and response to different drugs. Advancements in high-throughput sequencing technology have provided more insight into human genetic makeup and enabled better understanding of the link between genetic variations and health outcomes. However, despite considerable progress in human genetics, there are still many diseases that, given their complexity, cannot be explained simply by the genetic variants present and the involvement of factors such as epigenetics, environmental factors, and gene–environment interactions must be considered. We will discuss how human genetic diversity helps us to uncover the underlining mechanisms in monogenic, complex, and infectious diseases leading to a personalized approach to drug development and treatment. PB - Academic Press T2 - Biodiversity and Biomedicine T1 - Chapter 8 - Human genetic diversity in health and disease EP - 136 SP - 123 DO - 10.1016/B978-0-12-819541-3.00008-6 ER -
@inbook{ author = "Divac Rankov, Aleksandra and Ljujić, Mila", year = "2020", abstract = "Estimated human genetic diversity is 0.1%, meaning that any two individuals differ at approximately one in every thousand base pairs. A small proportion of these genetic variants have functional consequences affecting health, including susceptibility to infections, diseases, and response to different drugs. Advancements in high-throughput sequencing technology have provided more insight into human genetic makeup and enabled better understanding of the link between genetic variations and health outcomes. However, despite considerable progress in human genetics, there are still many diseases that, given their complexity, cannot be explained simply by the genetic variants present and the involvement of factors such as epigenetics, environmental factors, and gene–environment interactions must be considered. We will discuss how human genetic diversity helps us to uncover the underlining mechanisms in monogenic, complex, and infectious diseases leading to a personalized approach to drug development and treatment.", publisher = "Academic Press", journal = "Biodiversity and Biomedicine", booktitle = "Chapter 8 - Human genetic diversity in health and disease", pages = "136-123", doi = "10.1016/B978-0-12-819541-3.00008-6" }
Divac Rankov, A.,& Ljujić, M.. (2020). Chapter 8 - Human genetic diversity in health and disease. in Biodiversity and Biomedicine Academic Press., 123-136. https://doi.org/10.1016/B978-0-12-819541-3.00008-6
Divac Rankov A, Ljujić M. Chapter 8 - Human genetic diversity in health and disease. in Biodiversity and Biomedicine. 2020;:123-136. doi:10.1016/B978-0-12-819541-3.00008-6 .
Divac Rankov, Aleksandra, Ljujić, Mila, "Chapter 8 - Human genetic diversity in health and disease" in Biodiversity and Biomedicine (2020):123-136, https://doi.org/10.1016/B978-0-12-819541-3.00008-6 . .