Nature-inspired synthetic analogues of quorum sensing signaling molecules as novel therapeutics against Pseudomonas aeruginosa infections
Само за регистроване кориснике
2020
Поглавље у монографији (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The rapid emergence of antibiotic-resistant pathogens presents a global healthcare challenge. Bacteria control their virulence, motility, and biofilm formation, all of them being required for establishing pathogenicity, through a cell density-dependent communication system known as quorum sensing (QS). QS comprises production of extracellular signaling molecules, their detection, and population-wide response involving regulation of the virulence genes expression. Inhibition of QS affects virulence and reduces harmful effects to the host and as such presents a promising strategy to fight antibiotic-resistant infections. Multiresistant Pseudomonas aeruginosa belogns to the group of most critical pathogens for which the introduction of new therapeutics is imperative. In the search for novel therapeutics nature continues to be inexhaustible source of bioactive scaffolds, which provide the bases for structure-based rational drug design enabling further exploitation of diverse natural struct...ures. This review describes bacterial QS systems, highlights strategies for their manipulation, overviews nature-inspired antivirulence molecules primarily against P. aeruginosa, and discusses their perspectives.
Кључне речи:
Antibiotic resistance / antivirulence / autoinducer / biofilm / quorum sensing / synthetic inhibitorИзвор:
Biodiversity and Biomedicine, 2020, 497-523Издавач:
- Academic Press
Повезане информације:
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - CHAP AU - Šenerović, Lidija AU - Morić, Ivana AU - Milivojević, Dušan AU - Opsenica, Dejan PY - 2020 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1639 AB - The rapid emergence of antibiotic-resistant pathogens presents a global healthcare challenge. Bacteria control their virulence, motility, and biofilm formation, all of them being required for establishing pathogenicity, through a cell density-dependent communication system known as quorum sensing (QS). QS comprises production of extracellular signaling molecules, their detection, and population-wide response involving regulation of the virulence genes expression. Inhibition of QS affects virulence and reduces harmful effects to the host and as such presents a promising strategy to fight antibiotic-resistant infections. Multiresistant Pseudomonas aeruginosa belogns to the group of most critical pathogens for which the introduction of new therapeutics is imperative. In the search for novel therapeutics nature continues to be inexhaustible source of bioactive scaffolds, which provide the bases for structure-based rational drug design enabling further exploitation of diverse natural structures. This review describes bacterial QS systems, highlights strategies for their manipulation, overviews nature-inspired antivirulence molecules primarily against P. aeruginosa, and discusses their perspectives. PB - Academic Press T2 - Biodiversity and Biomedicine T2 - Biodiversity and Biomedicine T1 - Nature-inspired synthetic analogues of quorum sensing signaling molecules as novel therapeutics against Pseudomonas aeruginosa infections EP - 523 SP - 497 DO - 10.1016/B978-0-12-819541-3.00025-6 ER -
@inbook{ author = "Šenerović, Lidija and Morić, Ivana and Milivojević, Dušan and Opsenica, Dejan", year = "2020", abstract = "The rapid emergence of antibiotic-resistant pathogens presents a global healthcare challenge. Bacteria control their virulence, motility, and biofilm formation, all of them being required for establishing pathogenicity, through a cell density-dependent communication system known as quorum sensing (QS). QS comprises production of extracellular signaling molecules, their detection, and population-wide response involving regulation of the virulence genes expression. Inhibition of QS affects virulence and reduces harmful effects to the host and as such presents a promising strategy to fight antibiotic-resistant infections. Multiresistant Pseudomonas aeruginosa belogns to the group of most critical pathogens for which the introduction of new therapeutics is imperative. In the search for novel therapeutics nature continues to be inexhaustible source of bioactive scaffolds, which provide the bases for structure-based rational drug design enabling further exploitation of diverse natural structures. This review describes bacterial QS systems, highlights strategies for their manipulation, overviews nature-inspired antivirulence molecules primarily against P. aeruginosa, and discusses their perspectives.", publisher = "Academic Press", journal = "Biodiversity and Biomedicine, Biodiversity and Biomedicine", booktitle = "Nature-inspired synthetic analogues of quorum sensing signaling molecules as novel therapeutics against Pseudomonas aeruginosa infections", pages = "523-497", doi = "10.1016/B978-0-12-819541-3.00025-6" }
Šenerović, L., Morić, I., Milivojević, D.,& Opsenica, D.. (2020). Nature-inspired synthetic analogues of quorum sensing signaling molecules as novel therapeutics against Pseudomonas aeruginosa infections. in Biodiversity and Biomedicine Academic Press., 497-523. https://doi.org/10.1016/B978-0-12-819541-3.00025-6
Šenerović L, Morić I, Milivojević D, Opsenica D. Nature-inspired synthetic analogues of quorum sensing signaling molecules as novel therapeutics against Pseudomonas aeruginosa infections. in Biodiversity and Biomedicine. 2020;:497-523. doi:10.1016/B978-0-12-819541-3.00025-6 .
Šenerović, Lidija, Morić, Ivana, Milivojević, Dušan, Opsenica, Dejan, "Nature-inspired synthetic analogues of quorum sensing signaling molecules as novel therapeutics against Pseudomonas aeruginosa infections" in Biodiversity and Biomedicine (2020):497-523, https://doi.org/10.1016/B978-0-12-819541-3.00025-6 . .