Interactions of the eNOS and ACE genes and cigarette smoking in chronic obstructive pulmonary disease
Interakcije eNOS i ACE gena i duvanskog dima u hroničnoj opstruktivnoj bolesti pluća
Аутори
Stanković, MarijaĐorđević, Valentina
Tomović, Valentina
Nagorni-Obradović, Ljudmila
Petrović-Stanojević, Nataša
Kovač, Mirjana
Radojković, Dragica
Остала ауторства
Majkić-Singh, NadaЧланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background: Chronic obstructive pulmonary disease(COPD) is a complex disorder with unexplained heritability.Interactions of genetic and environmental factors arethought to be crucial in COPD. So, we aim to examineinteractions of the endothelial nitric oxide synthase (eNOS)and angiotensin converting enzyme (ACE) genes and ciga-rette smoking in COPD. Methods:The eNOS G894T and ACE ID variants wereanalyzed in 122 COPD patients and 200 controls fromSerbia. The effect of the variants on COPD was assessed bylogistic regression. Interactions between eNOS, ACE andcigarette smoking in COPD were evaluated using a case-control model. Interaction between the genes was analyzedin silico. Results:No effect of the eNOS G894T and ACE ID variantson COPD was found in our study. Gene-gene interactionbetween the eNOS TT and ACE D was identified(p=0.033) in COPD. The interaction is realized within the complex network of biochemical pathways. G...ene-environ-ment interactions between the eNOS T and cigarettesmoking (p=0.013), and the ACE II and cigarette smoking(p=0.009) were detected in COPD in our study. Conclusions:This is the first research to reveal interactionsof the eNOS and ACE genes and cigarette smoking inCOPD progressing our understanding of COPD heritabilityand contributing to the development of appropriate treat-ments.
Uvod: Hronična opstruktivna bolest pluća (HOBP) je složeno oboljenje sa nerazjašnjenom genetičkom osnovom.Smatra se da su interakcije genetskih i spoljašnjih faktora ključne u HOBP. Stoga je naš cilj bio da ispitamo interakcijegena za endotelijalnu azot-monoksid sintazu (eNOS) i angiotenzin konvertujući enzim (ACE) i duvanskog dima uHOBP. Metode :eNOS G894T i ACE ID varijante su analiziranekod 122 HOBP pacijenta i 200 kontrola iz Srbije. Uticajvarijanti na HOBP je ispitan logističkom regresijom. Interakcije izme|u eNOS, ACE i duvanskog dima u HOBP suispitane korišćenjem modela slučaj-kontrola. Interakciaja između gena je analizirana in silico. Rezultati: Prema ovoj studiji eNOS G894T i ACE ID varijante nemaju uticaj na HOBP. Gen-gen interakcija između eNOS TT i ACE D je identifikovana (p=0,033) u HOBP.Ova interakcija se ostvaruje u okviru složene mreže bio-hemijskih puteva. Gen-sredina interakcije izme|u eNOS Ti duvanskog dima (p=0,013), i ACE II i duvanskog dima(p=0,009) su detektovan...e u HOBP u ovoj studiji.Zaključak: Ovo je prvo istraživanje u kome su otkriveneinterakcije između eNOS i ACE gena i duvanskog dima uHOBP što doprinosi našem razumevanju genetičke osnove HOBP i razvoju adekvatnog tretmana.
Кључне речи:
COPD / eNOS / ACE / cigarette smoking / gene-gene interaction / gene-environment interaction / HOBP / eNOS / ACE / duvanski dim / gen-geninterakcija / gen-sredina interakcijaИзвор:
Journal of Medical Biochemistry, 2023, 41, 1, 94-104Издавач:
- Belgrade : Society of Medical Biochemists of Serbia
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200042 (Универзитет у Београду, Институт за молекуларну генетику и генетичко инжењерство) (RS-MESTD-inst-2020-200042)
Колекције
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Stanković, Marija AU - Đorđević, Valentina AU - Tomović, Valentina AU - Nagorni-Obradović, Ljudmila AU - Petrović-Stanojević, Nataša AU - Kovač, Mirjana AU - Radojković, Dragica PY - 2023 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1654 AB - Background: Chronic obstructive pulmonary disease(COPD) is a complex disorder with unexplained heritability.Interactions of genetic and environmental factors arethought to be crucial in COPD. So, we aim to examineinteractions of the endothelial nitric oxide synthase (eNOS)and angiotensin converting enzyme (ACE) genes and ciga-rette smoking in COPD. Methods:The eNOS G894T and ACE ID variants wereanalyzed in 122 COPD patients and 200 controls fromSerbia. The effect of the variants on COPD was assessed bylogistic regression. Interactions between eNOS, ACE andcigarette smoking in COPD were evaluated using a case-control model. Interaction between the genes was analyzedin silico. Results:No effect of the eNOS G894T and ACE ID variantson COPD was found in our study. Gene-gene interactionbetween the eNOS TT and ACE D was identified(p=0.033) in COPD. The interaction is realized within the complex network of biochemical pathways. Gene-environ-ment interactions between the eNOS T and cigarettesmoking (p=0.013), and the ACE II and cigarette smoking(p=0.009) were detected in COPD in our study. Conclusions:This is the first research to reveal interactionsof the eNOS and ACE genes and cigarette smoking inCOPD progressing our understanding of COPD heritabilityand contributing to the development of appropriate treat-ments. AB - Uvod: Hronična opstruktivna bolest pluća (HOBP) je složeno oboljenje sa nerazjašnjenom genetičkom osnovom.Smatra se da su interakcije genetskih i spoljašnjih faktora ključne u HOBP. Stoga je naš cilj bio da ispitamo interakcijegena za endotelijalnu azot-monoksid sintazu (eNOS) i angiotenzin konvertujući enzim (ACE) i duvanskog dima uHOBP. Metode :eNOS G894T i ACE ID varijante su analiziranekod 122 HOBP pacijenta i 200 kontrola iz Srbije. Uticajvarijanti na HOBP je ispitan logističkom regresijom. Interakcije izme|u eNOS, ACE i duvanskog dima u HOBP suispitane korišćenjem modela slučaj-kontrola. Interakciaja između gena je analizirana in silico. Rezultati: Prema ovoj studiji eNOS G894T i ACE ID varijante nemaju uticaj na HOBP. Gen-gen interakcija između eNOS TT i ACE D je identifikovana (p=0,033) u HOBP.Ova interakcija se ostvaruje u okviru složene mreže bio-hemijskih puteva. Gen-sredina interakcije izme|u eNOS Ti duvanskog dima (p=0,013), i ACE II i duvanskog dima(p=0,009) su detektovane u HOBP u ovoj studiji.Zaključak: Ovo je prvo istraživanje u kome su otkriveneinterakcije između eNOS i ACE gena i duvanskog dima uHOBP što doprinosi našem razumevanju genetičke osnove HOBP i razvoju adekvatnog tretmana. PB - Belgrade : Society of Medical Biochemists of Serbia T2 - Journal of Medical Biochemistry T1 - Interactions of the eNOS and ACE genes and cigarette smoking in chronic obstructive pulmonary disease T1 - Interakcije eNOS i ACE gena i duvanskog dima u hroničnoj opstruktivnoj bolesti pluća EP - 104 IS - 1 SP - 94 VL - 41 DO - 10.5937/jomb0-34017 ER -
@article{ author = "Stanković, Marija and Đorđević, Valentina and Tomović, Valentina and Nagorni-Obradović, Ljudmila and Petrović-Stanojević, Nataša and Kovač, Mirjana and Radojković, Dragica", year = "2023", abstract = "Background: Chronic obstructive pulmonary disease(COPD) is a complex disorder with unexplained heritability.Interactions of genetic and environmental factors arethought to be crucial in COPD. So, we aim to examineinteractions of the endothelial nitric oxide synthase (eNOS)and angiotensin converting enzyme (ACE) genes and ciga-rette smoking in COPD. Methods:The eNOS G894T and ACE ID variants wereanalyzed in 122 COPD patients and 200 controls fromSerbia. The effect of the variants on COPD was assessed bylogistic regression. Interactions between eNOS, ACE andcigarette smoking in COPD were evaluated using a case-control model. Interaction between the genes was analyzedin silico. Results:No effect of the eNOS G894T and ACE ID variantson COPD was found in our study. Gene-gene interactionbetween the eNOS TT and ACE D was identified(p=0.033) in COPD. The interaction is realized within the complex network of biochemical pathways. Gene-environ-ment interactions between the eNOS T and cigarettesmoking (p=0.013), and the ACE II and cigarette smoking(p=0.009) were detected in COPD in our study. Conclusions:This is the first research to reveal interactionsof the eNOS and ACE genes and cigarette smoking inCOPD progressing our understanding of COPD heritabilityand contributing to the development of appropriate treat-ments., Uvod: Hronična opstruktivna bolest pluća (HOBP) je složeno oboljenje sa nerazjašnjenom genetičkom osnovom.Smatra se da su interakcije genetskih i spoljašnjih faktora ključne u HOBP. Stoga je naš cilj bio da ispitamo interakcijegena za endotelijalnu azot-monoksid sintazu (eNOS) i angiotenzin konvertujući enzim (ACE) i duvanskog dima uHOBP. Metode :eNOS G894T i ACE ID varijante su analiziranekod 122 HOBP pacijenta i 200 kontrola iz Srbije. Uticajvarijanti na HOBP je ispitan logističkom regresijom. Interakcije izme|u eNOS, ACE i duvanskog dima u HOBP suispitane korišćenjem modela slučaj-kontrola. Interakciaja između gena je analizirana in silico. Rezultati: Prema ovoj studiji eNOS G894T i ACE ID varijante nemaju uticaj na HOBP. Gen-gen interakcija između eNOS TT i ACE D je identifikovana (p=0,033) u HOBP.Ova interakcija se ostvaruje u okviru složene mreže bio-hemijskih puteva. Gen-sredina interakcije izme|u eNOS Ti duvanskog dima (p=0,013), i ACE II i duvanskog dima(p=0,009) su detektovane u HOBP u ovoj studiji.Zaključak: Ovo je prvo istraživanje u kome su otkriveneinterakcije između eNOS i ACE gena i duvanskog dima uHOBP što doprinosi našem razumevanju genetičke osnove HOBP i razvoju adekvatnog tretmana.", publisher = "Belgrade : Society of Medical Biochemists of Serbia", journal = "Journal of Medical Biochemistry", title = "Interactions of the eNOS and ACE genes and cigarette smoking in chronic obstructive pulmonary disease, Interakcije eNOS i ACE gena i duvanskog dima u hroničnoj opstruktivnoj bolesti pluća", pages = "104-94", number = "1", volume = "41", doi = "10.5937/jomb0-34017" }
Stanković, M., Đorđević, V., Tomović, V., Nagorni-Obradović, L., Petrović-Stanojević, N., Kovač, M.,& Radojković, D.. (2023). Interactions of the eNOS and ACE genes and cigarette smoking in chronic obstructive pulmonary disease. in Journal of Medical Biochemistry Belgrade : Society of Medical Biochemists of Serbia., 41(1), 94-104. https://doi.org/10.5937/jomb0-34017
Stanković M, Đorđević V, Tomović V, Nagorni-Obradović L, Petrović-Stanojević N, Kovač M, Radojković D. Interactions of the eNOS and ACE genes and cigarette smoking in chronic obstructive pulmonary disease. in Journal of Medical Biochemistry. 2023;41(1):94-104. doi:10.5937/jomb0-34017 .
Stanković, Marija, Đorđević, Valentina, Tomović, Valentina, Nagorni-Obradović, Ljudmila, Petrović-Stanojević, Nataša, Kovač, Mirjana, Radojković, Dragica, "Interactions of the eNOS and ACE genes and cigarette smoking in chronic obstructive pulmonary disease" in Journal of Medical Biochemistry, 41, no. 1 (2023):94-104, https://doi.org/10.5937/jomb0-34017 . .