Molekularni markeri u sistemskoj sklerozi: geni kandidati i terapijski modaliteti
Molecular markers in systemic sclerosis: candidate genes and therapeutic modalities
Authors
Spasovski, VesnaVreća, Miša
Contributors
Pavlović, SonjaBegović, Jelena
Novaković, Ivana
Savić Pavićević, Dušanka
Đorđević, Ana
Book part (Published version)
Metadata
Show full item recordAbstract
Sistemska skleroza je izuzetno složeno i heterogeno oboljenje u pogledu kliničke prezentacije, progresije
bolesti, zahvaćenosti organa i ishodu. Na individualnom nivou, ova složenost predstavlja izazov u predviđanju
progresije bolesti i lečenju. U ovom radu će biti prikazana dosadašnja saznanja o molekularnim
markerima u sistemskoj sklerozi, signalnim putevima koji su uključeni u patogenezu, kao i njihova uloga u
kliničkoj prezentaciji bolesti. Biće predstavljeni novi terapijski pristupi u lečenju, sa posebnim osvrtom na biološku
terapiju zasnovanu na genima kandidatima, kao i mogućnosti koje regenerativna medicina nudi u
lečenju ove autoimune sistemske bolesti.
Systemic sclerosis is an extremely complex and heterogeneous disease in terms of clinical presentation, disease
progression, organ involvement, and outcome. At the individual level, this complexity presents a challenge
in predicting disease progression and treatment. This paper will present the current knowledge about
molecular markers in systemic sclerosis, signaling pathways involved in pathogenesis, as well as their role
in the clinical presentation of the disease. New therapeutic approaches in treatment will be presented, with
special emphasis on biological therapy based on candidate genes, as well as the possibilities that regenerative
medicine offers in the treatment of this autoimmune systemic disease.
Keywords:
sistemska skleroza / molekularni markeri / biološka terapija / regenerativna medicina / systemic sclerosis / molecular markers / biological therapy / regenerative medicineSource:
Trendovi u molekularnoj Biologiji, 2021, 107-112Publisher:
- Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200042 (University of Belgrade, Institute of Molecular Genetics and Genetic Engineering) (RS-MESTD-inst-2020-200042)
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Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - CHAP AU - Spasovski, Vesna AU - Vreća, Miša PY - 2021 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1719 AB - Sistemska skleroza je izuzetno složeno i heterogeno oboljenje u pogledu kliničke prezentacije, progresije bolesti, zahvaćenosti organa i ishodu. Na individualnom nivou, ova složenost predstavlja izazov u predviđanju progresije bolesti i lečenju. U ovom radu će biti prikazana dosadašnja saznanja o molekularnim markerima u sistemskoj sklerozi, signalnim putevima koji su uključeni u patogenezu, kao i njihova uloga u kliničkoj prezentaciji bolesti. Biće predstavljeni novi terapijski pristupi u lečenju, sa posebnim osvrtom na biološku terapiju zasnovanu na genima kandidatima, kao i mogućnosti koje regenerativna medicina nudi u lečenju ove autoimune sistemske bolesti. AB - Systemic sclerosis is an extremely complex and heterogeneous disease in terms of clinical presentation, disease progression, organ involvement, and outcome. At the individual level, this complexity presents a challenge in predicting disease progression and treatment. This paper will present the current knowledge about molecular markers in systemic sclerosis, signaling pathways involved in pathogenesis, as well as their role in the clinical presentation of the disease. New therapeutic approaches in treatment will be presented, with special emphasis on biological therapy based on candidate genes, as well as the possibilities that regenerative medicine offers in the treatment of this autoimmune systemic disease. PB - Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo T2 - Trendovi u molekularnoj Biologiji T1 - Molekularni markeri u sistemskoj sklerozi: geni kandidati i terapijski modaliteti T1 - Molecular markers in systemic sclerosis: candidate genes and therapeutic modalities EP - 112 SP - 107 UR - https://hdl.handle.net/21.15107/rcub_imagine_1719 ER -
@inbook{ author = "Spasovski, Vesna and Vreća, Miša", year = "2021", abstract = "Sistemska skleroza je izuzetno složeno i heterogeno oboljenje u pogledu kliničke prezentacije, progresije bolesti, zahvaćenosti organa i ishodu. Na individualnom nivou, ova složenost predstavlja izazov u predviđanju progresije bolesti i lečenju. U ovom radu će biti prikazana dosadašnja saznanja o molekularnim markerima u sistemskoj sklerozi, signalnim putevima koji su uključeni u patogenezu, kao i njihova uloga u kliničkoj prezentaciji bolesti. Biće predstavljeni novi terapijski pristupi u lečenju, sa posebnim osvrtom na biološku terapiju zasnovanu na genima kandidatima, kao i mogućnosti koje regenerativna medicina nudi u lečenju ove autoimune sistemske bolesti., Systemic sclerosis is an extremely complex and heterogeneous disease in terms of clinical presentation, disease progression, organ involvement, and outcome. At the individual level, this complexity presents a challenge in predicting disease progression and treatment. This paper will present the current knowledge about molecular markers in systemic sclerosis, signaling pathways involved in pathogenesis, as well as their role in the clinical presentation of the disease. New therapeutic approaches in treatment will be presented, with special emphasis on biological therapy based on candidate genes, as well as the possibilities that regenerative medicine offers in the treatment of this autoimmune systemic disease.", publisher = "Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo", journal = "Trendovi u molekularnoj Biologiji", booktitle = "Molekularni markeri u sistemskoj sklerozi: geni kandidati i terapijski modaliteti, Molecular markers in systemic sclerosis: candidate genes and therapeutic modalities", pages = "112-107", url = "https://hdl.handle.net/21.15107/rcub_imagine_1719" }
Spasovski, V.,& Vreća, M.. (2021). Molekularni markeri u sistemskoj sklerozi: geni kandidati i terapijski modaliteti. in Trendovi u molekularnoj Biologiji Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo., 107-112. https://hdl.handle.net/21.15107/rcub_imagine_1719
Spasovski V, Vreća M. Molekularni markeri u sistemskoj sklerozi: geni kandidati i terapijski modaliteti. in Trendovi u molekularnoj Biologiji. 2021;:107-112. https://hdl.handle.net/21.15107/rcub_imagine_1719 .
Spasovski, Vesna, Vreća, Miša, "Molekularni markeri u sistemskoj sklerozi: geni kandidati i terapijski modaliteti" in Trendovi u molekularnoj Biologiji (2021):107-112, https://hdl.handle.net/21.15107/rcub_imagine_1719 .