Molekularni markeri u sistemskoj sklerozi: geni kandidati i terapijski modaliteti

Abstract

Sistemska skleroza je izuzetno složeno i heterogeno oboljenje u pogledu kliničke prezentacije, progresije bolesti, zahvaćenosti organa i ishodu. Na individualnom nivou, ova složenost predstavlja izazov u predviđanju progresije bolesti i lečenju. U ovom radu će biti prikazana dosadašnja saznanja o molekularnim markerima u sistemskoj sklerozi, signalnim putevima koji su uključeni u patogenezu, kao i njihova uloga u kliničkoj prezentaciji bolesti. Biće predstavljeni novi terapijski pristupi u lečenju, sa posebnim osvrtom na biološku terapiju zasnovanu na genima kandidatima, kao i mogućnosti koje regenerativna medicina nudi u lečenju ove autoimune sistemske bolesti.

Systemic sclerosis is an extremely complex and heterogeneous disease in terms of clinical presentation, disease progression, organ involvement, and outcome. At the individual level, this complexity presents a challenge in predicting disease progression and treatment. This paper will present the current knowledge about molecular markers in systemic sclerosis, signaling pathways involved in pathogenesis, as well as their role in the clinical presentation of the disease. New therapeutic approaches in treatment will be presented, with special emphasis on biological therapy based on candidate genes, as well as the possibilities that regenerative medicine offers in the treatment of this autoimmune systemic disease.