alpha-Tocopherol Acetate Attenuates Mitochondrial Oxygen Consumption and Maintains Primitive Cells within Mesenchymal Stromal Cell Population
Аутори
Loncarić, DarijaRodriguez, Laura
Debeissat, Christelle
Touya, Nicolas
Labat, Veronique
Villacreces, Arnaud
Bouzier-Sore, Anne-Karine
Pasquet, Jean-Max
de la Grange, Philippe Brunet
Vlaski-Lafarge, Marija
Pavlović, Sonja
Ivanović, Zoran
Чланак у часопису (Рецензирана верзија)
Метаподаци
Приказ свих података о документуАпстракт
We present here the data showing, in standard cultures exposed to atmospheric O-2 concentration, that alpha-tocopherol acetate (alpha-TOA) has a positive impact on primitive cells inside mesenchymal stromal cell (MstroC) population, by maintaining their proliferative capacity. alpha-TOA decreases the O-2 consumption rate of MStroC probably by impacting respiratory chain complex II activity. This action, however, is not associated with a compensatory increase in glycolysis activity, in spite of the fact that the degradation of HIF-1 alpha was decreased in presence of alpha-TOA. This is in line with a moderate enhancement of mtROS upon alpha-TOA treatment. However, the absence of glycolysis stimulation implies the inactivity of HIF-1 alpha which might - if it were active - be related to the maintenance of stemness. It should be stressed that alpha-TOA might act directly on the gene expression as well as the mtROS themselves, which remains to be elucidated.
Кључне речи:
mtROS / MStroC / MSC / MPC / HIF-1 alpha / Electron transport chain / Alpha-tocopherol acetateИзвор:
Stem Cell Reviews and Reports, 2021, 17, 4, 1390-1405Издавач:
- Springer, New York
Финансирање / пројекти:
- A.E.C. T Euro region Aquitania-Euskadi-Navarra (2019/3) grant "Cardioreg"
- Ретке болести: молекуларна патофизиологија, дијагностички и терапијски модалитети и социјални, етички и правни аспекти (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41004)
Напомена:
- This is the peer reviewed version of the paper: Loncarić, D., Rodriguez, L., Debeissat, C., Touya, N., Labat, V., Villacreces, A., Bouzier-Sore, A.-K., Pasquet, J.-M., de la Grange, P. B., Vlaski-Lafarge, M., Pavlović, S., & Ivanović, Z. (2021). Alpha-Tocopherol Acetate Attenuates Mitochondrial Oxygen Consumption and Maintains Primitive Cells within Mesenchymal Stromal Cell Population. Stem Cell Reviews and Reports, 17(4), 1390–1405. https://doi.org/10.1007/s12015-020-10111-9
- Related to published version: https://imagine.imgge.bg.ac.rs/handle/123456789/1491
Повезане информације:
- Друга верзија
https://imagine.imgge.bg.ac.rs/handle/123456789/1491
DOI: 10.1007/s12015-020-10111-9
ISSN: 2629-3269
PubMed: 33511517
WoS: 000612560600001
Scopus: 2-s2.0-85099907001
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Loncarić, Darija AU - Rodriguez, Laura AU - Debeissat, Christelle AU - Touya, Nicolas AU - Labat, Veronique AU - Villacreces, Arnaud AU - Bouzier-Sore, Anne-Karine AU - Pasquet, Jean-Max AU - de la Grange, Philippe Brunet AU - Vlaski-Lafarge, Marija AU - Pavlović, Sonja AU - Ivanović, Zoran PY - 2021 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1754 AB - We present here the data showing, in standard cultures exposed to atmospheric O-2 concentration, that alpha-tocopherol acetate (alpha-TOA) has a positive impact on primitive cells inside mesenchymal stromal cell (MstroC) population, by maintaining their proliferative capacity. alpha-TOA decreases the O-2 consumption rate of MStroC probably by impacting respiratory chain complex II activity. This action, however, is not associated with a compensatory increase in glycolysis activity, in spite of the fact that the degradation of HIF-1 alpha was decreased in presence of alpha-TOA. This is in line with a moderate enhancement of mtROS upon alpha-TOA treatment. However, the absence of glycolysis stimulation implies the inactivity of HIF-1 alpha which might - if it were active - be related to the maintenance of stemness. It should be stressed that alpha-TOA might act directly on the gene expression as well as the mtROS themselves, which remains to be elucidated. PB - Springer, New York T2 - Stem Cell Reviews and Reports T1 - alpha-Tocopherol Acetate Attenuates Mitochondrial Oxygen Consumption and Maintains Primitive Cells within Mesenchymal Stromal Cell Population EP - 1405 IS - 4 SP - 1390 VL - 17 DO - 10.1007/s12015-020-10111-9 ER -
@article{ author = "Loncarić, Darija and Rodriguez, Laura and Debeissat, Christelle and Touya, Nicolas and Labat, Veronique and Villacreces, Arnaud and Bouzier-Sore, Anne-Karine and Pasquet, Jean-Max and de la Grange, Philippe Brunet and Vlaski-Lafarge, Marija and Pavlović, Sonja and Ivanović, Zoran", year = "2021", abstract = "We present here the data showing, in standard cultures exposed to atmospheric O-2 concentration, that alpha-tocopherol acetate (alpha-TOA) has a positive impact on primitive cells inside mesenchymal stromal cell (MstroC) population, by maintaining their proliferative capacity. alpha-TOA decreases the O-2 consumption rate of MStroC probably by impacting respiratory chain complex II activity. This action, however, is not associated with a compensatory increase in glycolysis activity, in spite of the fact that the degradation of HIF-1 alpha was decreased in presence of alpha-TOA. This is in line with a moderate enhancement of mtROS upon alpha-TOA treatment. However, the absence of glycolysis stimulation implies the inactivity of HIF-1 alpha which might - if it were active - be related to the maintenance of stemness. It should be stressed that alpha-TOA might act directly on the gene expression as well as the mtROS themselves, which remains to be elucidated.", publisher = "Springer, New York", journal = "Stem Cell Reviews and Reports", title = "alpha-Tocopherol Acetate Attenuates Mitochondrial Oxygen Consumption and Maintains Primitive Cells within Mesenchymal Stromal Cell Population", pages = "1405-1390", number = "4", volume = "17", doi = "10.1007/s12015-020-10111-9" }
Loncarić, D., Rodriguez, L., Debeissat, C., Touya, N., Labat, V., Villacreces, A., Bouzier-Sore, A., Pasquet, J., de la Grange, P. B., Vlaski-Lafarge, M., Pavlović, S.,& Ivanović, Z.. (2021). alpha-Tocopherol Acetate Attenuates Mitochondrial Oxygen Consumption and Maintains Primitive Cells within Mesenchymal Stromal Cell Population. in Stem Cell Reviews and Reports Springer, New York., 17(4), 1390-1405. https://doi.org/10.1007/s12015-020-10111-9
Loncarić D, Rodriguez L, Debeissat C, Touya N, Labat V, Villacreces A, Bouzier-Sore A, Pasquet J, de la Grange PB, Vlaski-Lafarge M, Pavlović S, Ivanović Z. alpha-Tocopherol Acetate Attenuates Mitochondrial Oxygen Consumption and Maintains Primitive Cells within Mesenchymal Stromal Cell Population. in Stem Cell Reviews and Reports. 2021;17(4):1390-1405. doi:10.1007/s12015-020-10111-9 .
Loncarić, Darija, Rodriguez, Laura, Debeissat, Christelle, Touya, Nicolas, Labat, Veronique, Villacreces, Arnaud, Bouzier-Sore, Anne-Karine, Pasquet, Jean-Max, de la Grange, Philippe Brunet, Vlaski-Lafarge, Marija, Pavlović, Sonja, Ivanović, Zoran, "alpha-Tocopherol Acetate Attenuates Mitochondrial Oxygen Consumption and Maintains Primitive Cells within Mesenchymal Stromal Cell Population" in Stem Cell Reviews and Reports, 17, no. 4 (2021):1390-1405, https://doi.org/10.1007/s12015-020-10111-9 . .