Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity
Autori
Smederevac, SnežanaDelgado-Cruzata, Lissette
Mitrović, Dušanka
Dinić, Bojana M.
Bravo, Toni-Ann T.
Delgado, Maria
Bugarski Ignjatović, Vojislava
Sadiković, Selka
Milovanović, Ilija
Vučinić, Nataša
Branovački, Bojan
Prinz, Mechthild
Budimlija, Zoran
Kušić‐Tišma, Jelena
Nikolašević, Željka
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Epigenetic modifications of the membrane bound catechol-O-methyltransferase (MB-COMT) gene may affect the enzymatic degradation of dopamine, and consequently, human behavior. This study investigated the association between membrane bound catechol-O-methyltransferase DNA methylation (DNAm) differences in 92 monozygotic (MZ) twins with phenotypic manifestations of cognitive, behavioral, and personality indicators associated with reward-related behaviors and lack of control. We used pyrosequencing to determine DNAm of the regulatory region of membrane bound catechol-O-methyltransferase in saliva DNA. Results of intrapair differences in the percentage of membrane bound catechol-O-methyltransferase DNAm at each of five CpG sites show that there are associations between phenotypic indicators of lack of control and membrane bound catechol-O-methyltransferase DNAm differences on CpG1, CpG2 and CpG4, suggesting the common epigenetic patterns for personality traits, cognitive functions, and risk... behaviors.
Ključne reči:
MB-COMT / DNA methylation / monozygotic twins / risk behavior / executive functions (EFs) / impulsivity / aggression / personalityIzvor:
Frontiers in Genetics, 2023, 13Finansiranje / projekti:
- GENIUS - Genetic and environmental influences on psychological adaptation of children and adults (RS-ScienceFundRS-Ideje-7744418)
Povezane informacije:
- Druga verzija
https://doi.org/10.3389/fgene.2022.1067276
URI
https://www.frontiersin.org/articles/10.3389/fgene.2022.1067276https://imagine.imgge.bg.ac.rs/handle/123456789/1765
Kolekcije
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Smederevac, Snežana AU - Delgado-Cruzata, Lissette AU - Mitrović, Dušanka AU - Dinić, Bojana M. AU - Bravo, Toni-Ann T. AU - Delgado, Maria AU - Bugarski Ignjatović, Vojislava AU - Sadiković, Selka AU - Milovanović, Ilija AU - Vučinić, Nataša AU - Branovački, Bojan AU - Prinz, Mechthild AU - Budimlija, Zoran AU - Kušić‐Tišma, Jelena AU - Nikolašević, Željka PY - 2023 UR - https://www.frontiersin.org/articles/10.3389/fgene.2022.1067276 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1765 AB - Epigenetic modifications of the membrane bound catechol-O-methyltransferase (MB-COMT) gene may affect the enzymatic degradation of dopamine, and consequently, human behavior. This study investigated the association between membrane bound catechol-O-methyltransferase DNA methylation (DNAm) differences in 92 monozygotic (MZ) twins with phenotypic manifestations of cognitive, behavioral, and personality indicators associated with reward-related behaviors and lack of control. We used pyrosequencing to determine DNAm of the regulatory region of membrane bound catechol-O-methyltransferase in saliva DNA. Results of intrapair differences in the percentage of membrane bound catechol-O-methyltransferase DNAm at each of five CpG sites show that there are associations between phenotypic indicators of lack of control and membrane bound catechol-O-methyltransferase DNAm differences on CpG1, CpG2 and CpG4, suggesting the common epigenetic patterns for personality traits, cognitive functions, and risk behaviors. T2 - Frontiers in Genetics T2 - Frontiers in Genetics T1 - Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity VL - 13 DO - 10.3389/fgene.2022.1067276 ER -
@article{ author = "Smederevac, Snežana and Delgado-Cruzata, Lissette and Mitrović, Dušanka and Dinić, Bojana M. and Bravo, Toni-Ann T. and Delgado, Maria and Bugarski Ignjatović, Vojislava and Sadiković, Selka and Milovanović, Ilija and Vučinić, Nataša and Branovački, Bojan and Prinz, Mechthild and Budimlija, Zoran and Kušić‐Tišma, Jelena and Nikolašević, Željka", year = "2023", abstract = "Epigenetic modifications of the membrane bound catechol-O-methyltransferase (MB-COMT) gene may affect the enzymatic degradation of dopamine, and consequently, human behavior. This study investigated the association between membrane bound catechol-O-methyltransferase DNA methylation (DNAm) differences in 92 monozygotic (MZ) twins with phenotypic manifestations of cognitive, behavioral, and personality indicators associated with reward-related behaviors and lack of control. We used pyrosequencing to determine DNAm of the regulatory region of membrane bound catechol-O-methyltransferase in saliva DNA. Results of intrapair differences in the percentage of membrane bound catechol-O-methyltransferase DNAm at each of five CpG sites show that there are associations between phenotypic indicators of lack of control and membrane bound catechol-O-methyltransferase DNAm differences on CpG1, CpG2 and CpG4, suggesting the common epigenetic patterns for personality traits, cognitive functions, and risk behaviors.", journal = "Frontiers in Genetics, Frontiers in Genetics", title = "Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity", volume = "13", doi = "10.3389/fgene.2022.1067276" }
Smederevac, S., Delgado-Cruzata, L., Mitrović, D., Dinić, B. M., Bravo, T. T., Delgado, M., Bugarski Ignjatović, V., Sadiković, S., Milovanović, I., Vučinić, N., Branovački, B., Prinz, M., Budimlija, Z., Kušić‐Tišma, J.,& Nikolašević, Ž.. (2023). Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity. in Frontiers in Genetics, 13. https://doi.org/10.3389/fgene.2022.1067276
Smederevac S, Delgado-Cruzata L, Mitrović D, Dinić BM, Bravo TT, Delgado M, Bugarski Ignjatović V, Sadiković S, Milovanović I, Vučinić N, Branovački B, Prinz M, Budimlija Z, Kušić‐Tišma J, Nikolašević Ž. Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity. in Frontiers in Genetics. 2023;13. doi:10.3389/fgene.2022.1067276 .
Smederevac, Snežana, Delgado-Cruzata, Lissette, Mitrović, Dušanka, Dinić, Bojana M., Bravo, Toni-Ann T., Delgado, Maria, Bugarski Ignjatović, Vojislava, Sadiković, Selka, Milovanović, Ilija, Vučinić, Nataša, Branovački, Bojan, Prinz, Mechthild, Budimlija, Zoran, Kušić‐Tišma, Jelena, Nikolašević, Željka, "Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity" in Frontiers in Genetics, 13 (2023), https://doi.org/10.3389/fgene.2022.1067276 . .