dc.creator | Novović, Katarina | |
dc.creator | Jovčić, Branko | |
dc.date.accessioned | 2023-03-08T13:17:37Z | |
dc.date.available | 2023-03-08T13:17:37Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 2079-6382 | |
dc.identifier.uri | https://imagine.imgge.bg.ac.rs/handle/123456789/1786 | |
dc.description.abstract | : Acinetobacter baumannii is recognized as a clinically significant pathogen causing a wide
spectrum of nosocomial infections. Colistin was considered a last-resort antibiotic for the treatment of
infections caused by multidrug-resistant A. baumannii. Since the reintroduction of colistin, a number
of mechanisms of colistin resistance in A. baumannii have been reported, including complete loss of
LPS by inactivation of the biosynthetic pathway, modifications of target LPS driven by the addition
of phosphoethanolamine (PEtN) moieties to lipid A mediated by the chromosomal pmrCAB operon
and eptA gene-encoded enzymes or plasmid-encoded mcr genes and efflux of colistin from the cell.
In addition to resistance to colistin, widespread heteroresistance is another feature of A. baumannii
that leads to colistin treatment failure. This review aims to present a critical assessment of relevant
published (>50 experimental papers) up-to-date knowledge on the molecular mechanisms of colistin
resistance in A. baumannii with a detailed review of implicated mutations and the global distribution
of colistin-resistant strains. | sr |
dc.language.iso | en | sr |
dc.publisher | MDPI | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200042/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200178/RS// | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Antibiotics | sr |
dc.subject | Acinetobacter baumannii | sr |
dc.subject | colistin resistance | sr |
dc.subject | lpx | sr |
dc.subject | pmr | sr |
dc.subject | mcr | sr |
dc.subject | LPS | sr |
dc.subject | lipid A | sr |
dc.subject | phosphoethanolamine transferase | sr |
dc.subject | epidemiology | sr |
dc.title | Colistin resistance in acinetobacter baumannii: Molecular mechanisms and epidemiology | sr |
dc.type | article | sr |
dc.rights.license | BY | sr |
dc.citation.issue | 3 | |
dc.citation.rank | M21~ | |
dc.citation.spage | 516 | |
dc.citation.volume | 12 | |
dc.identifier.doi | 10.3390/antibiotics12030516 | |
dc.identifier.fulltext | https://imagine.imgge.bg.ac.rs/bitstream/id/107304/Colistin_Resistance_in_Acinetobacter_baumannii_Molecular_Mechanisms_and_Epidemiology_2023.pdf | |
dc.type.version | publishedVersion | sr |