Uloga hsa-miR-93-5p u kolorektalnom karcinomu

Abstract

Kolorektalni karcinom predstavlja heterogenu bolest koja zauzima treće i drugo mesto na svetu po stepenu incidence i stopi mortaliteta, respektivno. Poznato je da mikroRNK molekuli imaju ključne uloge u procesu patogeneze, progresije i metastaziranja kolorektalnog karcinoma, ali i rezistenciji na hemioterapiju. U različitim tumorima je pokazano da hsa-miR-93-5p može imati onkogenu, ali i tumor-supresorsku ulogu. Ovaj rad ima za cilj da predstavi dosadašnja saznanja o ulozi hsa-miR-93-5p u procesima vezanim za kolorektalnu karcinogenezu, metastaziranje i odgovor na hemioterapiju kod pacijenata sa kolorektalnim karcinomom. Rad takođe razmatra hsa-miR-93-5p kao potencijalni prognostički i prediktivni biomarker i primenu ovog molekula u kliničkoj praksi.

Colorectal cancer is a heterogeneous disease that ranks third and second globally in terms of incidence and mortality rates, respectively. MicroRNAs have been implicated in the growth, progression, metastasis and response to therapy of different tumors, including colorectal cancer. Hsa-miR-93-5p has been reported to have oncogenic and tumor-suppressive roles in different tumor kinds. This review article aims to present the current knowledge on the role of hsa-miR-93-5p in the processes related to colorectal carcinogenesis, metastasis and response to chemotherapy in patients with primary and metastatic colorectal cancer. Also, the role of hsa-miR-93-5p as a potential prognostic and predictive biomarker and application of this molecule in the clinical practice is described.