Coumarin-palladium(II) complex acts as a potent and nontoxic anticancer agent against pancreatic carcinoma cells
Аутори
Krstić, AleksandraPavić, Aleksandar
Balint, Vanda
Lazić, Stefan
Avdović, Edina
Marković, Zoran
Pejić, Jelena
Stevanović, Milena
Petrović, Isidora
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Pancreatic carcinoma represents one of the most lethal malignant diseases in the world although some
progress has been made in treating the disease in the past decades. Current multi-agent treatment options
have improved the overall survival of patients, but more effective treatment strategies are still needed. In this
paper we have characterized anticancer potential of coumarin-palladium(II) complex against pancreatic
carcinoma cells. Cells viability, colony formation and migratory potential of pancreatic carcinoma cells were
assessed in vitro, followed by evaluation of apoptosis induction and in vivo testing on zebrafish. Presented
results showed remarkable reduction in pancreatic carcinoma cells growth both in vitro and in vivo, being
effective at micromolar concentrations (0.5 M). Treatments induced apoptosis, increased BAX/BCL-2 ratio
and suppressed the expression of SOX9 and SOX18, genes shown to be significantly up-regulated in
pancreatic ductal adenocarcinoma. Importa...ntly, treatments of the zebrafish-pancreatic adenocarcinoma
xenografts resulted in significant reduction of tumor mass, while did not provoke any adverse toxic effects
including hepatotoxicity. Presented results indicate the great potential of tested compound and the
perspective of its further development towards pancreatic cancer therapy.
Кључне речи:
pancreatic carcinoma / coumarin palladium(II) complex / coumarin derivatives / anticancerИзвор:
RAD International concerence on radiation in various fields of research, 2022, Spring Edition, 34-Напомена:
- BOOK OF ABSTRACTS: 10th JUBILEE INTERNATIONAL CONFERENCE ON RADIATION IN VARIOUS FIELDS OF RESEARCH Jun 13-17, 2022, Herceg Novi - Montenegro
URI
https://doi.org/10.21175/rad.spr.abstr.book.2022.9.3https://imagine.imgge.bg.ac.rs/handle/123456789/1866
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - CONF AU - Krstić, Aleksandra AU - Pavić, Aleksandar AU - Balint, Vanda AU - Lazić, Stefan AU - Avdović, Edina AU - Marković, Zoran AU - Pejić, Jelena AU - Stevanović, Milena AU - Petrović, Isidora PY - 2022 UR - https://doi.org/10.21175/rad.spr.abstr.book.2022.9.3 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1866 AB - Pancreatic carcinoma represents one of the most lethal malignant diseases in the world although some progress has been made in treating the disease in the past decades. Current multi-agent treatment options have improved the overall survival of patients, but more effective treatment strategies are still needed. In this paper we have characterized anticancer potential of coumarin-palladium(II) complex against pancreatic carcinoma cells. Cells viability, colony formation and migratory potential of pancreatic carcinoma cells were assessed in vitro, followed by evaluation of apoptosis induction and in vivo testing on zebrafish. Presented results showed remarkable reduction in pancreatic carcinoma cells growth both in vitro and in vivo, being effective at micromolar concentrations (0.5 M). Treatments induced apoptosis, increased BAX/BCL-2 ratio and suppressed the expression of SOX9 and SOX18, genes shown to be significantly up-regulated in pancreatic ductal adenocarcinoma. Importantly, treatments of the zebrafish-pancreatic adenocarcinoma xenografts resulted in significant reduction of tumor mass, while did not provoke any adverse toxic effects including hepatotoxicity. Presented results indicate the great potential of tested compound and the perspective of its further development towards pancreatic cancer therapy. C3 - RAD International concerence on radiation in various fields of research T1 - Coumarin-palladium(II) complex acts as a potent and nontoxic anticancer agent against pancreatic carcinoma cells IS - Spring Edition SP - 34 DO - 10.21175/rad.spr.abstr.book.2022.9.3 ER -
@conference{ author = "Krstić, Aleksandra and Pavić, Aleksandar and Balint, Vanda and Lazić, Stefan and Avdović, Edina and Marković, Zoran and Pejić, Jelena and Stevanović, Milena and Petrović, Isidora", year = "2022", abstract = "Pancreatic carcinoma represents one of the most lethal malignant diseases in the world although some progress has been made in treating the disease in the past decades. Current multi-agent treatment options have improved the overall survival of patients, but more effective treatment strategies are still needed. In this paper we have characterized anticancer potential of coumarin-palladium(II) complex against pancreatic carcinoma cells. Cells viability, colony formation and migratory potential of pancreatic carcinoma cells were assessed in vitro, followed by evaluation of apoptosis induction and in vivo testing on zebrafish. Presented results showed remarkable reduction in pancreatic carcinoma cells growth both in vitro and in vivo, being effective at micromolar concentrations (0.5 M). Treatments induced apoptosis, increased BAX/BCL-2 ratio and suppressed the expression of SOX9 and SOX18, genes shown to be significantly up-regulated in pancreatic ductal adenocarcinoma. Importantly, treatments of the zebrafish-pancreatic adenocarcinoma xenografts resulted in significant reduction of tumor mass, while did not provoke any adverse toxic effects including hepatotoxicity. Presented results indicate the great potential of tested compound and the perspective of its further development towards pancreatic cancer therapy.", journal = "RAD International concerence on radiation in various fields of research", title = "Coumarin-palladium(II) complex acts as a potent and nontoxic anticancer agent against pancreatic carcinoma cells", number = "Spring Edition", pages = "34", doi = "10.21175/rad.spr.abstr.book.2022.9.3" }
Krstić, A., Pavić, A., Balint, V., Lazić, S., Avdović, E., Marković, Z., Pejić, J., Stevanović, M.,& Petrović, I.. (2022). Coumarin-palladium(II) complex acts as a potent and nontoxic anticancer agent against pancreatic carcinoma cells. in RAD International concerence on radiation in various fields of research(Spring Edition), 34. https://doi.org/10.21175/rad.spr.abstr.book.2022.9.3
Krstić A, Pavić A, Balint V, Lazić S, Avdović E, Marković Z, Pejić J, Stevanović M, Petrović I. Coumarin-palladium(II) complex acts as a potent and nontoxic anticancer agent against pancreatic carcinoma cells. in RAD International concerence on radiation in various fields of research. 2022;(Spring Edition):34. doi:10.21175/rad.spr.abstr.book.2022.9.3 .
Krstić, Aleksandra, Pavić, Aleksandar, Balint, Vanda, Lazić, Stefan, Avdović, Edina, Marković, Zoran, Pejić, Jelena, Stevanović, Milena, Petrović, Isidora, "Coumarin-palladium(II) complex acts as a potent and nontoxic anticancer agent against pancreatic carcinoma cells" in RAD International concerence on radiation in various fields of research, no. Spring Edition (2022):34, https://doi.org/10.21175/rad.spr.abstr.book.2022.9.3 . .