Bioinformatics analysis of eukaryotic positively oriented single stranded RNA viruses
Аутори
Banović Đeri, BojanaVidanović, Dejan
Bojana, Tešović
Petrović, Tamaš
Ristić, Danijela
Vučurović, Ivan
Dudić, Dragana
Остала ауторства
Matavulj, MilicaКонференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Positively oriented single stranded RNA viruses [ssRNA(+)] persistently affect health and well-being of all
eukaryotes, including plants, animals and humans (i.e. SARS-CoV-2, yellow fever, hepatitis C, zika, West Nile,
pepper mild mottle virus, etc.). How come these viruses are so wide spread and hard to eradicate? Besides
their high changeability, another major reason is their ability to mimic host processes upon entering the host.
Only recently it was revealed that ssRNA(+) viruses undergo methylation inside the host in the process that
is similar to the methylation of the hosts’ own mRNAs. Such process may enable or disable virus to avoid
some of the host’s defense mechanisms, but it inevitably impacts viral stability and fitness.
Studies on this topic have only started, opening even more questions, with major ones being: how ssRNA(+)
methylation, that occurs in the host, impacts viral pathogenicity and are these methylation patterns different
in different hosts and for dif...ferent ssRNA(+) viruses or do these viral methylomes share more universal
pattern in concordance with their similar genome organization? Among numerous different methylation
patterns of RNA, this research focused on N6-methyladenosine (m6A), as the most common and abundant
methylation in eukaryotes, which was confirmed to be present in ssRNA(+) viruses as well.
This study searched for patterns in the primary sequences and secondary structures of ssRNA(+) that are
associated to m6A methylation sites relying on the experimentally obtained m6A datasets for eukaryotes and
eukaryotic ssRNA(+) viruses. The results are discussed in view of datasets characteristics and study approach.
Кључне речи:
bioinformatics / m6A / methylome pattern / single stranded RNA viruses / ssRNA(+)Извор:
Biologia Serbica, 2021, 43, 1 (Special Edition), 29-Издавач:
- Novi Sad : Faculty of Sciences, Department of Biology and Ecology
Напомена:
- Book of Abstracts: Belgrade BioInformatics Conference 2021
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - CONF AU - Banović Đeri, Bojana AU - Vidanović, Dejan AU - Bojana, Tešović AU - Petrović, Tamaš AU - Ristić, Danijela AU - Vučurović, Ivan AU - Dudić, Dragana PY - 2021 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1869 AB - Positively oriented single stranded RNA viruses [ssRNA(+)] persistently affect health and well-being of all eukaryotes, including plants, animals and humans (i.e. SARS-CoV-2, yellow fever, hepatitis C, zika, West Nile, pepper mild mottle virus, etc.). How come these viruses are so wide spread and hard to eradicate? Besides their high changeability, another major reason is their ability to mimic host processes upon entering the host. Only recently it was revealed that ssRNA(+) viruses undergo methylation inside the host in the process that is similar to the methylation of the hosts’ own mRNAs. Such process may enable or disable virus to avoid some of the host’s defense mechanisms, but it inevitably impacts viral stability and fitness. Studies on this topic have only started, opening even more questions, with major ones being: how ssRNA(+) methylation, that occurs in the host, impacts viral pathogenicity and are these methylation patterns different in different hosts and for different ssRNA(+) viruses or do these viral methylomes share more universal pattern in concordance with their similar genome organization? Among numerous different methylation patterns of RNA, this research focused on N6-methyladenosine (m6A), as the most common and abundant methylation in eukaryotes, which was confirmed to be present in ssRNA(+) viruses as well. This study searched for patterns in the primary sequences and secondary structures of ssRNA(+) that are associated to m6A methylation sites relying on the experimentally obtained m6A datasets for eukaryotes and eukaryotic ssRNA(+) viruses. The results are discussed in view of datasets characteristics and study approach. PB - Novi Sad : Faculty of Sciences, Department of Biology and Ecology C3 - Biologia Serbica T1 - Bioinformatics analysis of eukaryotic positively oriented single stranded RNA viruses IS - 1 (Special Edition) SP - 29 VL - 43 UR - https://hdl.handle.net/21.15107/rcub_imagine_1869 ER -
@conference{ author = "Banović Đeri, Bojana and Vidanović, Dejan and Bojana, Tešović and Petrović, Tamaš and Ristić, Danijela and Vučurović, Ivan and Dudić, Dragana", year = "2021", abstract = "Positively oriented single stranded RNA viruses [ssRNA(+)] persistently affect health and well-being of all eukaryotes, including plants, animals and humans (i.e. SARS-CoV-2, yellow fever, hepatitis C, zika, West Nile, pepper mild mottle virus, etc.). How come these viruses are so wide spread and hard to eradicate? Besides their high changeability, another major reason is their ability to mimic host processes upon entering the host. Only recently it was revealed that ssRNA(+) viruses undergo methylation inside the host in the process that is similar to the methylation of the hosts’ own mRNAs. Such process may enable or disable virus to avoid some of the host’s defense mechanisms, but it inevitably impacts viral stability and fitness. Studies on this topic have only started, opening even more questions, with major ones being: how ssRNA(+) methylation, that occurs in the host, impacts viral pathogenicity and are these methylation patterns different in different hosts and for different ssRNA(+) viruses or do these viral methylomes share more universal pattern in concordance with their similar genome organization? Among numerous different methylation patterns of RNA, this research focused on N6-methyladenosine (m6A), as the most common and abundant methylation in eukaryotes, which was confirmed to be present in ssRNA(+) viruses as well. This study searched for patterns in the primary sequences and secondary structures of ssRNA(+) that are associated to m6A methylation sites relying on the experimentally obtained m6A datasets for eukaryotes and eukaryotic ssRNA(+) viruses. The results are discussed in view of datasets characteristics and study approach.", publisher = "Novi Sad : Faculty of Sciences, Department of Biology and Ecology", journal = "Biologia Serbica", title = "Bioinformatics analysis of eukaryotic positively oriented single stranded RNA viruses", number = "1 (Special Edition)", pages = "29", volume = "43", url = "https://hdl.handle.net/21.15107/rcub_imagine_1869" }
Banović Đeri, B., Vidanović, D., Bojana, T., Petrović, T., Ristić, D., Vučurović, I.,& Dudić, D.. (2021). Bioinformatics analysis of eukaryotic positively oriented single stranded RNA viruses. in Biologia Serbica Novi Sad : Faculty of Sciences, Department of Biology and Ecology., 43(1 (Special Edition)), 29. https://hdl.handle.net/21.15107/rcub_imagine_1869
Banović Đeri B, Vidanović D, Bojana T, Petrović T, Ristić D, Vučurović I, Dudić D. Bioinformatics analysis of eukaryotic positively oriented single stranded RNA viruses. in Biologia Serbica. 2021;43(1 (Special Edition)):29. https://hdl.handle.net/21.15107/rcub_imagine_1869 .
Banović Đeri, Bojana, Vidanović, Dejan, Bojana, Tešović, Petrović, Tamaš, Ristić, Danijela, Vučurović, Ivan, Dudić, Dragana, "Bioinformatics analysis of eukaryotic positively oriented single stranded RNA viruses" in Biologia Serbica, 43, no. 1 (Special Edition) (2021):29, https://hdl.handle.net/21.15107/rcub_imagine_1869 .