Molecular profiling of rare thymoma using next-generation sequencing: meta-analysis
Authors
Kostić Perić, JelenaĆirković, Anđa
Srzentić Dražilov, Sanja
Samardžić, Natalija
Trifunović, Vesna Skodrić
Jovanović, Dragana
Pavlović, Sonja
Article (Published version)
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AbstractBackgroundThymomas belong to rare tumors giving rise to thymic epithelial tissue. There is a classification of several forms of thymoma: A, AB, B1, B2, B3, thymic carcinoma (TC) and thymic neuroendocrine thymoma. In this meta-analysis study, we have focused on thymoma using articles based on the disease’s next-generation sequencing (NGS) genomic profiling.Materials and methodsWe conducted a systematic review and meta-analysis of the prevalence of studies that discovered the genes and variants occurring in the less aggressive forms of the thymic epithelial tumors. Studies published before 12th December 2022 were identified through PubMed, Web of Science (WoS), and SCOPUS databases. Two reviewers have searched for the bases and selected the articles for the final analysis, based on well-defined exclusion and inclusion criteria.ResultsFinally, 12 publications were included in the qualitative as well as quantitative analysis. The three genes, GTF2I, TP53, and HRAS, emerged as disea...se-significant in the observed studies. The Odds Ratio for all three extracted genes GTF2I (OR = 1.58, CI [1.51, 1.66] p < 0.00001), TP53 (OR = 1.36, CI [1.12, 1.65], p < 0.002), and HRAS (OR = 1.02, CI [1.00, 1.04], p < 0.001).ConclusionsAccording to obtained data, we noticed that the GTF2I gene exhibits a significant prevalence in
Source:
Radiology and Oncology, 2023, 57, 1, 12-19Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200042 (University of Belgrade, Institute of Molecular Genetics and Genetic Engineering) (RS-MESTD-inst-2020-200042)
URI
https://sciendo.com/article/10.2478/raon-2023-0013https://imagine.imgge.bg.ac.rs/handle/123456789/1885
Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Kostić Perić, Jelena AU - Ćirković, Anđa AU - Srzentić Dražilov, Sanja AU - Samardžić, Natalija AU - Trifunović, Vesna Skodrić AU - Jovanović, Dragana AU - Pavlović, Sonja PY - 2023 UR - https://sciendo.com/article/10.2478/raon-2023-0013 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1885 AB - AbstractBackgroundThymomas belong to rare tumors giving rise to thymic epithelial tissue. There is a classification of several forms of thymoma: A, AB, B1, B2, B3, thymic carcinoma (TC) and thymic neuroendocrine thymoma. In this meta-analysis study, we have focused on thymoma using articles based on the disease’s next-generation sequencing (NGS) genomic profiling.Materials and methodsWe conducted a systematic review and meta-analysis of the prevalence of studies that discovered the genes and variants occurring in the less aggressive forms of the thymic epithelial tumors. Studies published before 12th December 2022 were identified through PubMed, Web of Science (WoS), and SCOPUS databases. Two reviewers have searched for the bases and selected the articles for the final analysis, based on well-defined exclusion and inclusion criteria.ResultsFinally, 12 publications were included in the qualitative as well as quantitative analysis. The three genes, GTF2I, TP53, and HRAS, emerged as disease-significant in the observed studies. The Odds Ratio for all three extracted genes GTF2I (OR = 1.58, CI [1.51, 1.66] p < 0.00001), TP53 (OR = 1.36, CI [1.12, 1.65], p < 0.002), and HRAS (OR = 1.02, CI [1.00, 1.04], p < 0.001).ConclusionsAccording to obtained data, we noticed that the GTF2I gene exhibits a significant prevalence in T2 - Radiology and Oncology T2 - Radiology and Oncology T2 - thymoma T2 - next-generation sequencing (NGS) T2 - SNVs/InDels T2 - meta-analysis T1 - Molecular profiling of rare thymoma using next-generation sequencing: meta-analysis EP - 19 IS - 1 SP - 12 VL - 57 DO - 10.2478/raon-2023-0013 ER -
@article{ author = "Kostić Perić, Jelena and Ćirković, Anđa and Srzentić Dražilov, Sanja and Samardžić, Natalija and Trifunović, Vesna Skodrić and Jovanović, Dragana and Pavlović, Sonja", year = "2023", abstract = "AbstractBackgroundThymomas belong to rare tumors giving rise to thymic epithelial tissue. There is a classification of several forms of thymoma: A, AB, B1, B2, B3, thymic carcinoma (TC) and thymic neuroendocrine thymoma. In this meta-analysis study, we have focused on thymoma using articles based on the disease’s next-generation sequencing (NGS) genomic profiling.Materials and methodsWe conducted a systematic review and meta-analysis of the prevalence of studies that discovered the genes and variants occurring in the less aggressive forms of the thymic epithelial tumors. Studies published before 12th December 2022 were identified through PubMed, Web of Science (WoS), and SCOPUS databases. Two reviewers have searched for the bases and selected the articles for the final analysis, based on well-defined exclusion and inclusion criteria.ResultsFinally, 12 publications were included in the qualitative as well as quantitative analysis. The three genes, GTF2I, TP53, and HRAS, emerged as disease-significant in the observed studies. The Odds Ratio for all three extracted genes GTF2I (OR = 1.58, CI [1.51, 1.66] p < 0.00001), TP53 (OR = 1.36, CI [1.12, 1.65], p < 0.002), and HRAS (OR = 1.02, CI [1.00, 1.04], p < 0.001).ConclusionsAccording to obtained data, we noticed that the GTF2I gene exhibits a significant prevalence in", journal = "Radiology and Oncology, Radiology and Oncology, thymoma, next-generation sequencing (NGS), SNVs/InDels, meta-analysis", title = "Molecular profiling of rare thymoma using next-generation sequencing: meta-analysis", pages = "19-12", number = "1", volume = "57", doi = "10.2478/raon-2023-0013" }
Kostić Perić, J., Ćirković, A., Srzentić Dražilov, S., Samardžić, N., Trifunović, V. S., Jovanović, D.,& Pavlović, S.. (2023). Molecular profiling of rare thymoma using next-generation sequencing: meta-analysis. in Radiology and Oncology, 57(1), 12-19. https://doi.org/10.2478/raon-2023-0013
Kostić Perić J, Ćirković A, Srzentić Dražilov S, Samardžić N, Trifunović VS, Jovanović D, Pavlović S. Molecular profiling of rare thymoma using next-generation sequencing: meta-analysis. in Radiology and Oncology. 2023;57(1):12-19. doi:10.2478/raon-2023-0013 .
Kostić Perić, Jelena, Ćirković, Anđa, Srzentić Dražilov, Sanja, Samardžić, Natalija, Trifunović, Vesna Skodrić, Jovanović, Dragana, Pavlović, Sonja, "Molecular profiling of rare thymoma using next-generation sequencing: meta-analysis" in Radiology and Oncology, 57, no. 1 (2023):12-19, https://doi.org/10.2478/raon-2023-0013 . .